Heart Lung and Circulation,
Journal Year:
2020,
Volume and Issue:
30(3), P. 324 - 349
Published: Dec. 10, 2020
Familial
hypercholesterolaemia
(FH)
is
a
dominant
and
highly
penetrant
monogenic
disorder
present
from
birth
that
markedly
elevates
plasma
low-density
lipoprotein
(LDL)-cholesterol
concentration
and,
if
untreated,
leads
to
premature
atherosclerosis
coronary
artery
disease
(CAD).
There
are
approximately
100,000
people
with
FH
in
Australia.
However,
an
overwhelming
majority
of
those
affected
remain
undetected
inadequately
treated,
consistent
being
leading
challenge
for
public
health
genomics.
To
further
address
the
unmet
need,
we
provide
updated
guidance,
presented
as
series
systematically
collated
recommendations,
on
care
patients
families
FH.
These
recommendations
have
been
informed
by
exponential
growth
published
works
new
evidence
over
last
5
years
compatible
contemporary
global
call
action
Recommendations
given
detection,
diagnosis,
assessment
management
adults
children.
also
made
genetic
testing
risk
notification
biological
relatives
who
should
undergo
cascade
Guidance
based
concepts
re-stratification,
adherence
heart
healthy
lifestyles,
treatment
non-cholesterol
factors,
safe
appropriate
use
LDL-cholesterol
lowering
therapies,
including
statins,
ezetimibe,
proprotein
convertase
subtilisin/kexin
type
9
inhibitors
apheresis.
Broad
provided
organisation
development
services.
best
practice
need
be
underpinned
good
clinical
judgment
shared
decision
making
families.
Models
adapted
local
regional
needs
available
resources.
A
comprehensive
realistic
implementation
strategy,
research,
assessments
cost-benefit,
will
required
ensure
this
guidance
benefits
all
Australian
or
at
Circulation,
Journal Year:
2022,
Volume and Issue:
145(8)
Published: Jan. 26, 2022
The
American
Heart
Association,
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
diet,
weight)
factors
(cholesterol,
blood
pressure,
glucose
control)
that
contribute
health.
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
congenital
rhythm
disorders,
subclinical
atherosclerosis,
coronary
failure,
valvular
venous
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
Circulation,
Journal Year:
2023,
Volume and Issue:
147(8)
Published: Jan. 25, 2023
Background:
The
American
Heart
Association,
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
diet,
weight)
factors
(cholesterol,
blood
pressure,
glucose
control)
that
contribute
health.
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
congenital
rhythm
disorders,
subclinical
atherosclerosis,
coronary
failure,
valvular
venous
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
Methods:
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
provide
current
information
available
annual
review
published
literature
year
before
writing.
2023
is
product
full
year’s
worth
effort
2022
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
Association
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
COVID-19
(coronavirus
2019)
publications,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
Results:
Each
chapters
focuses
different
topic
statistics.
Conclusions:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
Circulation,
Journal Year:
2024,
Volume and Issue:
149(8)
Published: Jan. 24, 2024
BACKGROUND:
The
American
Heart
Association
(AHA),
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
nutrition,
sleep,
obesity)
factors
(cholesterol,
blood
pressure,
glucose
control,
metabolic
syndrome)
that
contribute
health.
AHA
Disease
Stroke
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
brain
health,
complications
pregnancy,
kidney
congenital
rhythm
disorders,
sudden
cardiac
arrest,
subclinical
atherosclerosis,
coronary
cardiomyopathy,
failure,
valvular
venous
thromboembolism,
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
METHODS:
AHA,
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
globally
provide
current
information
available
annual
review
published
literature
year
before
writing.
2024
is
product
full
year’s
worth
effort
2023
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
global
data,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
RESULTS:
Each
chapters
focuses
different
topic
statistics.
CONCLUSIONS:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
