Human Gut Microbiota in Cardiovascular Disease DOI

Daniel Rönen,

Y Rokach,

Suzan Abedat

et al.

Comprehensive physiology, Journal Year: 2024, Volume and Issue: 14(3), P. 5449 - 5490

Published: July 1, 2024

Abstract The gut ecosystem, termed microbiota, is composed of bacteria, archaea, viruses, protozoa, and fungi estimated to outnumber human cells. Microbiota can affect the host by multiple mechanisms, including synthesis metabolites toxins, modulating inflammation interaction with other organisms. Advances in understanding commensal organisms' effect on conditions have also elucidated importance this community for cardiovascular disease (CVD). This driven both direct CV effects known increase risk, such as obesity, diabetes mellitus (DM), hypertension, renal liver diseases. Cardioactive metabolites, trimethylamine N ‐oxide (TMAO), short‐chain fatty acids (SCFA), lipopolysaccharides, bile acids, uremic atherosclerosis, platelet activation, inflammation, resulting increased incidence. Interestingly, bidirectional microbiota affected diet, acid secretion, diseases affecting barrier. interdependence makes manipulating an attractive option reduce risk. Indeed, evolving data suggest that benefits observed from low red meat Mediterranean diet consumption be explained, at least partially, changes these diets may microbiota. In article, we depict current epidemiological mechanistic role CVD. Finally, discuss potential therapeutic approaches aimed improve outcomes. © 2024 American Physiological Society. Compr Physiol 14:5449‐5490, 2024.

Language: Английский

The gut microbiome and hypertension DOI
Joanne A. O’Donnell, Tenghao Zheng, Guillaume Méric

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 19(3), P. 153 - 167

Published: Jan. 11, 2023

Language: Английский

Citations

137
Gut microbiota and hypertension: association, mechanisms and treatment DOI Creative Commons
Zhihua Yang, Qingchun Wang,

Yangxi Liu

et al.

Clinical and Experimental Hypertension, Journal Year: 2023, Volume and Issue: 45(1)

Published: March 30, 2023

Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular diseases, which brings a heavy economic burden to society and becomes major public health problem. At present, pathogenesis hypertension unclear. Increasing evidence has proven that closely related dysbiosis gut microbiota. We briefly reviewed relevant literature on microbiota summarize relationship between hypertension, linked antihypertension effects drugs with their modulation microbiota, discussed potential mechanisms various microbes active metabolites alleviate thus providing new research ideas development drugs.Methods The was collected systematically from scientific database, including Elsevier, PubMed, Web Science, China National Knowledge Infrastructure (CNKI), Baidu Scholar, as well other sources, such classic books herbal medicine.Results can lead imbalance barrier dysfunction, increased harmful bacteria hydrogen sulfide lipopolysaccharide, decreased beneficial short-chain fatty acids, intestinal tight junction proteins permeability. Gut occurrence hypertension. main methods regulate include fecal transplantation, supplementation probiotics, antibiotics, diet exercise, antihypertensive drugs, natural medicines.Conclusions Investigating correlation may help reveal perspective great significance prevention treatment

Language: Английский

Citations

87
Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study DOI Creative Commons

Lu Liu,

Qianyi Zhou,

Tianbao Xu

et al.

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research primarily focused on differential abundances, our study highlights the role of non-differential microbes in We propose that contribute hypertension through their ecological interactions, as defined co-abundances (pairs exhibiting correlated abundance patterns). Using gut microbiome data from Guangdong Gut Microbiome Project, which includes 2355 hypertensive 4644 non-hypertensive participants across 14 regions, we identified replicable hypertension-related interactions. Notably, most involved microbes, were found correlate with both severity metabolic pathways. These findings emphasize importance interactions pathogenesis a novel perspective for microbiome-based therapeutic strategies.

Language: Английский

Citations

2
Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics DOI Creative Commons
Sharlize Pedroza Matute, Sasitaran Iyavoo

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

Citations

43
How Dietary Fibre, Acting via the Gut Microbiome, Lowers Blood Pressure DOI Creative Commons
Chudan Xu, Francine Z. Marques

Current Hypertension Reports, Journal Year: 2022, Volume and Issue: 24(11), P. 509 - 521

Published: July 15, 2022

To discuss the interplay behind how a high-fibre diet leads to lower blood pressure (BP) via gut microbiome.

Language: Английский

Citations

38
Untapped potential of gut microbiome for hypertension management DOI Creative Commons
Kan Gao,

Pu Xiu Wang,

Xue Mei

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 2, 2024

The gut microbiota has been shown to be associated with a range of illnesses and disorders, including hypertension, which is recognized as the primary factor contributing development serious cardiovascular diseases. In this review, we conducted comprehensive analysis progression research domain pertaining hypertension. Our emphasis was on interplay between blood pressure that are mediated by host microbiota-derived metabolites. Additionally, elaborate reciprocal communication antihypertensive drugs, its influence host. field computer science seen rapid progress great potential in application biomedical sciences, prompt an exploration use microbiome databases artificial intelligence realm high prediction prevention. We propose biomarkers context hypertension prevention therapy.

Language: Английский

Citations

8
Prospects for Leveraging the Microbiota as Medicine for Hypertension DOI Creative Commons
David J. Durgan, Jasenka Zubcevic, Matam Vijay–Kumar

et al.

Hypertension, Journal Year: 2024, Volume and Issue: 81(5), P. 951 - 963

Published: April 17, 2024

Language: Английский

Citations

7
Research Progress on the Correlation Between Hypertension and Gut Microbiota DOI Creative Commons
Xiao-mei Cui, Ting Zhang, Tao Xie

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 2371 - 2387

Published: May 1, 2024

Among cardiovascular diseases, hypertension is the most important risk factor for morbidity and mortality worldwide, its pathogenesis complex, involving genetic, dietary environmental factors. The characteristics of gut microbiota can vary in response to increased blood pressure (BP) influence development progression hypertension. This paper describes five aspects relationship between microbiota, namely, different types metabolites sympathetic activation, gut-brain interactions, effects exercise patterns treatment through probiotics, faecal transplantation (FMT) herbal remedies, providing new clues future prevention Diet, traditional Chinese medicine may contribute long-term improvements hypertension, although probiotics FMT still need be validated large populations.

Language: Английский

Citations

7
Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages DOI Creative Commons
Jing Li, Siyuan Wang, Kaixin Yan

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(4)

Published: July 18, 2024

Dysbiosis of the gut microbiota has been implicated in hypertension, and drug-host-microbiome interactions have drawn considerable attention. However, influence angiotensin receptor blocker (ARB)-shaped on host is not fully understood. In this work, we assessed alterations blood pressure (BP), vasculatures, intestines following ARB-modified microbiome treatment evaluated changes intestinal transcriptome serum metabolome hypertensive rats. Hypertensive patients with well-controlled BP under ARB therapy were recruited as human donors, spontaneously rats (SHRs) receiving normal saline or valsartan considered animal SHRs regarded recipients. Histological immunofluorescence staining was used to assess aorta small intestine, 16S rRNA amplicon sequencing performed examine bacteria. Transcriptome metabonomic analyses conducted determine metabolome, respectively. Notably, fecal transplantation (FMT), results marked decreases systolic levels, collagen deposition reactive oxygen species accumulation vasculature, alleviated structure impairments SHRs. These linked reconstruction SHR recipients post-FMT, especially a decreased abundance

Language: Английский

Citations

7
Engineered probiotics Clostridium butyricum‐pMTL007‐GLP‐1 improves blood pressure via producing GLP‐1 and modulating gut microbiota in spontaneous hypertension rat models DOI Creative Commons

X Wang,

Wen‐jie Chen, Rui Jin

et al.

Microbial Biotechnology, Journal Year: 2022, Volume and Issue: 16(4), P. 799 - 812

Published: Dec. 18, 2022

Abstract Hypertension is a significant risk factor of cardiovascular diseases (CVDs) with high prevalence worldwide, the current treatment has multiple adverse effects and requires continuous administration. The glucagon‐like peptide‐1 receptor (GLP‐1R) agonists have shown great potential in treating diabetes mellitus, neurodegenerative diseases, obesity hypertension. Butyric acid target Yet, application GLP‐1 analogue butyric reducing blood pressure reversing ventricular hypertrophy remains untapped. In this study, we combined therapeutic capability by transforming Clostridium butyricum (CB) recombinant plasmid pMTL007 encoded hGLP gene to construct engineered probiotics ‐pMTL007‐GLP‐1 (CB‐GLP‐1). We used spontaneous hypertensive rat (SHR) models evaluate positive effect strain results revealed that intragastric administration CB‐GLP‐1 had markedly reduced improved cardiac marker ACE2, AT2R, AT1R, ANP, BNP, β‐MHC, α‐SMA activating AMPK/mTOR/p70S6K/4EBP1 signalling pathway. high‐throughput sequencing further demonstrated treatments significantly dysbiosis SHR rats via downregulating relative abundance Porphyromonadaceae at family level upregulating Lactobacillus genus level. Hence, concluded greatly improves cardiomegaly restoring gut microbiome models. This first time using CB hypertension, which provides new idea for clinical

Language: Английский

Citations

24