International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4818 - 4818
Published: May 17, 2025
Intestinal
microbiota
and
the
host’s
immune
system
form
a
symbiotic
alliance
that
sustains
normal
development
function
in
human
gut.
Changes
such
as
dietary
habits
among
societies
developed
countries
have
led
to
of
unbalanced
microbial
populations
gut,
likely
contributing
dramatic
increase
inflammatory
diseases
last
few
decades.
Recent
advances
DNA
sequencing
technologies
tremendously
helped
characterize
microbiome
associated
with
disease,
both
identifying
global
alterations
discovering
specific
biomarkers
potentially
contribute
disease
pathogenesis,
evidenced
by
animal
studies.
Beyond
bacterial
alterations,
non-bacterial
components
fungi,
viruses,
metabolites
been
implicated
these
diseases,
influencing
responses
gut
homeostasis.
Multi-omics
approaches
integrating
metagenomics,
metabolomics,
transcriptomics
offer
more
comprehensive
understanding
microbiome’s
role
paving
way
for
innovative
diagnostic
therapeutic
strategies.
Unraveling
metagenomic
profiles
may
facilitate
earlier
diagnosis
intervention,
well
personalized
effective
This
review
synthesizes
recent
relevant
research
studies
aimed
at
characterizing
signatures
bowel
colorectal
cancer,
celiac
disease.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(21), P. 6578 - 6578
Published: Nov. 1, 2024
Colorectal
cancer
(CRC)
constitutes
a
significant
global
health
challenge,
with
recent
studies
underscoring
the
pivotal
role
of
gut
microbiome
in
its
pathogenesis
and
progression.
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
compelling
therapeutic
approach,
offering
potential
to
modulate
microbial
composition
optimize
treatment
outcomes.
Research
suggests
that
specific
bacterial
strains
are
closely
linked
CRC,
influencing
both
clinical
management
interventions.
Moreover,
microbiome's
impact
on
immunotherapy
responsiveness
heralds
new
avenues
for
personalized
medicine.
Despite
promise
FMT,
safety
concerns,
particularly
immunocompromised
individuals,
remain
critical
issue.
Clinical
outcomes
vary
widely,
influenced
by
genetic
predispositions
methodologies
employed.
Additionally,
rigorous
donor
selection
screening
protocols
paramount
minimize
risks
maximize
efficacy.
The
current
body
literature
advocates
establishment
standardized
further
trials
substantiate
FMT's
CRC
management.
As
our
understanding
deepens,
FMT
is
poised
become
cornerstone
treatment,
imperative
continued
research
validation.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(4), P. 794 - 794
Published: April 14, 2024
To
advance
probiotic
research,
a
comprehensive
understanding
of
bacterial
interactions
with
human
physiology
at
the
molecular
and
cellular
levels
is
fundamental.
Lacticaseibacillus
rhamnosus
LGG®
strain
that
has
long
been
recognized
for
its
beneficial
effects
on
health.
Probiotic
effector
molecules
derived
from
LGG®,
including
secreted
proteins,
surface-anchored
polysaccharides,
lipoteichoic
acids,
which
interact
host
physiological
processes
have
identified.
In
vitro
animal
studies
revealed
specific
stimulate
epithelial
cell
survival,
preserve
intestinal
barrier
integrity,
reduce
oxidative
stress,
mitigate
excessive
mucosal
inflammation,
enhance
IgA
secretion,
provide
long-term
protection
through
epigenetic
imprinting.
Pili
surface
promote
adhesion
to
mucosa
ensure
close
contact
cells.
Extracellular
vesicles
produced
by
recapitulate
many
these
their
cargo
molecules.
Collectively,
exert
significant
influence
both
gut
immune
system,
promotes
homeostasis
tolerance.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 558 - 558
Published: Jan. 31, 2025
Alzheimer’s
disease
(AD)
is
the
most
common
form
of
dementia
and
characterized
by
memory
impairment
that
significantly
interferes
with
daily
life.
Therapeutic
options
for
AD
substantively
modify
progression
remain
a
critical
unmet
need.
In
this
regard,
gut
microbiota
crucial
in
maintaining
human
health
regulating
metabolism
immune
responses,
increasing
evidence
suggests
probiotics,
particularly
beneficial
bacteria,
can
enhance
cognitive
functions.
Recent
studies
have
highlighted
positive
effects
Bifidobacterium
breve
MCC1274
(B.
MCC1274)
on
individuals
mild
(MCI)
schizophrenia.
Additionally,
oral
supplementation
B.
has
been
shown
to
effectively
prevent
decline
AppNL–G–F
mice.
relation
pathology,
found
reduce
amyloid-β
(Aβ)
accumulation
tau
phosphorylation
both
wild-type
(WT)
It
also
decreases
microglial
activation
increases
levels
synaptic
proteins.
review,
we
examine
AD,
exploring
potential
mechanisms
action
how
probiotic
strain
may
aid
preventing
or
treating
disease.
Furthermore,
discuss
broader
implications
improving
overall
host
provide
insights
into
future
research
directions
promising
therapy.
International Journal of General Medicine,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 603 - 626
Published: Feb. 1, 2025
Abstract:
The
intestinal
microecology
is
comprises
microorganisms
and
other
components
constituting
the
entire
ecosystem,
presenting
characteristics
of
stability
dynamic
balance.
Current
research
reveals
microecological
imbalances
are
related
to
various
diseases.
However,
fundamental
clinical
applications
have
not
been
effectively
integrated.
Considering
importance
complexity
regulating
balance,
this
study
provides
an
overview
high-risk
factors
affecting
detection
methods.
Moreover,
it
proposes
definition
imbalance
definition,
formulation,
outcomes
gut
prescription
facilitate
its
application
in
practice,
thus
promoting
on
improving
quality
life
population.
Keywords:
microecology,
risk,
prescription,
faecal
microbiota
transplantation
Biotechnology and Applied Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
ABSTRACT
As
a
significant
cause
of
global
mortality,
the
cancer
has
also
economic
impacts.
In
era
therapy,
mitigating
side
effects
and
costs
overcoming
drug
resistance
is
crucial.
Microbial
species
can
grow
inside
tumor
microenvironment
inhibit
growth
through
direct
killing
cells
immunoregulatory
effects.
Although
microbiota
or
their
products
have
demonstrated
anticancer
effects,
possibility
acting
as
pathogens
exerting
in
certain
individuals
risk.
Hence,
several
genetically
modified/engineered
bacteria
(GEB)
been
developed
to
this
aim
with
ability
diagnosing
selective
targeting
destruction
cancers.
Additionally,
GEB
are
expected
be
considerably
more
efficient,
safer,
permeable,
less
costly,
invasive
theranostic
approaches
compared
wild
types.
Potential
strains
such
Escherichia
coli
(Nissle
1917,
MG1655),
Salmonella
typhimurium
YB1
SL7207
(
aroA
gene
deletion),
VNP20009
(∆msbB/∆purI)
ΔppGpp
(P
Tet
P
BAD
),
Listeria
monocytogenes
Lm
at
‐LLO
combat
cells.
When
used
tandem
conventional
treatments,
substantially
improve
efficacy
therapy
outcomes.
addition,
public
acceptance,
optimal
timing
(s),
duration
dose
identification,
interactions
other
host
cells,
efficacy,
safety
quality,
potential
risks
ethical
dilemmas
include
major
challenges.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
203, P. 107185 - 107185
Published: April 12, 2024
Microbes,
including
bacteria,
viruses,
fungi,
and
other
eukaryotic
organisms,
are
commonly
present
in
multiple
organs
of
the
human
body
contribute
significantly
to
both
physiological
pathological
processes.
Nowadays,
development
sequencing
technology
has
revealed
presence
composition
intratumoral
microbiota,
which
includes
Fusobacterium,
Bifidobacteria,
Bacteroides,
shed
light
on
significant
involvement
progression
colorectal
cancer
(CRC).
Here,
we
summarized
current
understanding
microbiota
CRC
outline
potential
translational
clinical
applications
diagnosis,
prevention,
treatment
CRC.
We
focused
reviewing
microbial
therapies
targeting
improve
efficacy
safety
chemotherapy
immunotherapy
for
identify
biomarkers
diagnosis
prognosis
Finally,
emphasized
obstacles
solutions
translating
knowledge
into
practice.
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(8), P. 646 - 646
Published: July 31, 2024
Clostridioides
difficile
is
the
main
causative
agent
of
antibiotic-associated
diarrhea
(AAD)
in
hospitals
developed
world.
Both
infected
patients
and
asymptomatic
colonized
individuals
represent
important
transmission
sources
C.
difficile.
infection
(CDI)
shows
a
large
range
symptoms,
from
mild
to
severe
manifestations
such
as
pseudomembranous
colitis.
Epidemiological
changes
CDIs
have
been
observed
last
two
decades,
with
emergence
highly
virulent
types
more
numerous
CDI
cases
community.
interacts
gut
microbiota
throughout
its
entire
life
cycle,
difficile’s
role
colonizer
or
invader
largely
depends
on
alterations
microbiota,
which
itself
can
promote
maintain.
The
restoration
healthy
state
considered
potentially
effective
for
prevention
treatment
CDI.
Besides
fecal
transplantation
(FMT),
many
other
approaches
re-establishing
intestinal
eubiosis
are
currently
under
investigation.
This
review
aims
explore
current
data
consideration
recent
types,
an
overview
microbial
interventions
used
restore
human
microbiota.
