Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 11, 2024
Cardiac
remodeling
is
a
shared
pathological
change
in
most
cardiovascular
diseases.
Encompassing
both
adaptive
physiological
responses
and
decompensated
changes.
Anatomically,
atrial
primarily
caused
by
fibrillation,
whereas
ventricular
typically
induced
myocardial
infarction,
hypertension,
or
cardiomyopathy.
Mitochondria,
the
powerhouse
of
cardiomyocytes,
collaborate
with
other
organelles
such
as
endoplasmic
reticulum
to
control
variety
pathophysiological
processes
calcium
signaling,
lipid
transfer,
mitochondrial
dynamics,
biogenesis,
mitophagy.
This
mechanism
proven
be
essential
for
cardiac
remodeling.
Post-translational
modifications
can
regulate
intracellular
signaling
pathways,
gene
expression,
cellular
stress
cells
modulating
protein
function,
stability,
interactions,
consequently
shaping
response
injury
stress.
These
modifications,
particular
phosphorylation,
acetylation,
ubiquitination,
are
regulation
complex
molecular
pathways
that
underlie
review
provides
comprehensive
overview
crosstalk
between
mitochondria
during
remodeling,
focusing
on
regulatory
effects
various
post-translational
these
interactions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4407 - 4407
Published: April 17, 2024
This
review
examines
the
impact
of
obesity
on
pathophysiology
heart
failure
with
preserved
ejection
fraction
(HFpEF)
and
focuses
novel
mechanisms
for
HFpEF
prevention
using
a
glucagon-like
peptide-1
receptor
agonism
(GLP-1
RA).
Obesity
can
lead
to
through
various
mechanisms,
including
low-grade
systemic
inflammation,
adipocyte
dysfunction,
accumulation
visceral
adipose
tissue,
increased
pericardial/epicardial
tissue
(contributing
an
increase
in
myocardial
fat
content
interstitial
fibrosis).
Glucagon-like
peptide
1
(GLP-1)
is
incretin
hormone
that
released
from
enteroendocrine
L-cells
gut.
GLP-1
reduces
blood
glucose
levels
by
stimulating
insulin
synthesis,
suppressing
islet
α-cell
function,
promoting
proliferation
differentiation
β-cells.
regulates
gastric
emptying
appetite,
RA
currently
indicated
treating
type
2
diabetes
(T2D),
obesity,
metabolic
syndrome
(MS).
Recent
evidence
indicates
may
play
significant
role
preventing
patients
MS,
or
obese
T2D.
effect
be
due
activating
cardioprotective
(the
endogenous
counter-regulatory
renin
angiotensin
system
AMPK/mTOR
pathway)
inhibiting
deleterious
remodeling
PKA/RhoA/ROCK
pathway,
aldosterone
levels,
microinflammation).
However,
there
still
need
further
research
validate
these
humans.
Cell Reports Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101987 - 101987
Published: March 1, 2025
Cardiac
ischemic
reperfusion
injury
(IRI)
significantly
exacerbates
cardiac
dysfunction
and
heart
failure,
causing
high
mortality.
Despite
the
severity
of
IRI,
effective
therapeutic
strategies
remain
elusive.
Acellular
patches
have
shown
considerable
efficacy
in
delivering
therapeutics
directly
to
tissues.
Herein,
we
develop
injectable
GelMA
(GEL)
hydrogels
with
controlled
mechanical
properties.
Targeting
miR-222-engineered
extracellular
vesicles
(TeEVs),
tailored
cardiac-ischemia-targeting
peptides
(CTPs),
are
developed
as
TeEV
therapeutics.
These
TeEVs
encapsulated
within
create
TeEV-loaded
patches,
enabling
minimal
invasiveness
attenuate
IRI.
The
facilitate
precise
targeting
for
efficient
rescue
damaged
cells.
Persistent
delivery
into
infarcted
region
alleviates
acute
IRI
mitigated
remodeling
post
This
is
linked
focal
adhesion
activation,
cytoskeleton
force
enhancement,
nuclear
force-sensing
preservation.
findings
may
pave
way
approaches
therapy
using
bioengineered
patches.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19173 - e19173
Published: March 24, 2025
Background
To
investigate
the
effect
of
degree
atrial
fibrosis
on
clot
burden
score
(CBS)
and
physicochemical
properties
in
patients
with
acute
ischaemic
stroke
(AIS)
due
to
non-valvular
fibrillation
(NVAF).
Methods
A
total
117
AIS
NVAF
attending
Department
Cardiovascular
Medicine
Cerebrovascular
Diagnostic
Treatment
Centre
between
August
2021
May
2024
were
included
study.
Baseline
clinical
data,
biochemical
indexes,
imaging
data
collected,
divided
into
93
cases
CBS
(score
0–6)
group
24
7–10)
according
CBS.
signifies
higher
burden.
The
enzyme-linked
immunosorbent
assay
was
used
measure
concentration
galactaglutinin-3
(gal-3)
transforming
growth
factor
(TGF-β1)
serum
patients,
PTFV1
collected
by
12-lead
electrocardiogram,
differences
different
groups
risk
factors
analysed.
analyse
collateral
circulation
stroke,
31
good
(grade
3–4)
86
poor
0–2)
digital
subtraction
angiography
(DSA)
images.
cerebral
thrombus
from
60
who
underwent
mechanical
thrombectomy.
content
erythrocyte,
fibrin/platelets
leukocytes
analysed
Mathew’s
scarlet
blue
staining,
density
measured
computed
tomography
(CT).
Results
this
study,
proportion
hypertensive
chronic
(CAF),
B-type
natriuretic
peptide
(BNP),
neutrophil/lymphocyte
ratio
(NLR),
D-dimer,
uric
acid
concentration,
<
−0.03
mm
s,
gal-3,
TGF-β1
as
compared
(
P
-value
0.05).
Hypertension,
CAF,
homocysteine,
NLR,
acid,
TGF-β1,
for
development
high
(AF),
hypertension
CAF
most
important
occurrence
AF
independent
combined
gal-3
circulation,
indexes
not
associated
pathological
composition
density.
Conclusions
Atrial
increases
but
does
significantly
correlate
thrombus.
