From Prodromal Stages to Clinical Trials: The Promise of Digital Speech Biomarkers in Parkinson's Disease
Neuroscience & Biobehavioral Reviews,
Journal Year:
2024,
Volume and Issue:
167, P. 105922 - 105922
Published: Oct. 18, 2024
Language: Английский
Mobility-Based Smartphone Digital Phenotypes Unobtrusively Capture Everyday Cognition, Mood, and Community Life-Space in Older Adults: A Pilot Study (Preprint)
Katherine Hackett,
No information about this author
Shiyun Xu,
No information about this author
Moira McKniff
No information about this author
et al.
JMIR Human Factors,
Journal Year:
2024,
Volume and Issue:
11, P. e59974 - e59974
Published: Sept. 30, 2024
Background
Current
methods
of
monitoring
cognition
in
older
adults
are
insufficient
to
address
the
growing
burden
Alzheimer
disease
and
related
dementias
(AD/ADRD).
New
approaches
that
sensitive,
scalable,
objective,
reflective
meaningful
functional
outcomes
direly
needed.
Mobility
trajectories
geospatial
life
space
patterns
reflect
many
aspects
cognitive
integrity
may
be
useful
proxies
age-related
decline.
Objective
We
investigated
feasibility,
acceptability,
preliminary
validity
a
1-month
smartphone
digital
phenotyping
protocol
infer
everyday
cognition,
function,
mood
from
passively
obtained
GPS
data.
also
sought
clarify
intrinsic
extrinsic
factors
associated
with
mobility
phenotypes
for
consideration
future
studies.
Methods
Overall,
37
aged
between
63
85
years
healthy
(n=31,
84%),
mild
impairment
(n=5,
13%),
dementia
(n=1,
3%)
used
an
open-source
app
(mindLAMP)
unobtrusively
capture
4
weeks.
data
were
processed
into
interpretable
features
across
categories
activity,
inactivity,
routine,
location
diversity.
Monthly
average
day-to-day
intraindividual
variability
(IIV)
metrics
calculated
each
feature
test
priori
hypotheses
neuropsychological
framework.
Validation
measures
collected
at
baseline
compared
against
monthly
examine
construct
validity.
Feasibility
acceptability
included
retention,
comprehension
study
procedures,
technical
difficulties,
satisfaction
ratings
debriefing.
Results
All
(37/37,
100%)
participants
completed
4-week
period
without
major
adverse
events,
100%
(37/37)
reported
explanation
97%
(36/37)
no
feelings
discomfort.
Participants’
scores
on
consent
quiz
education
race.
Technical
issues
requiring
troubleshooting
infrequent,
though
41%
(15/37)
battery
drain.
Moderate
strong
correlations
(r≥0.3)
identified
validators.
Specifically,
individuals
greater
activity
more
diversity
demonstrated
better
less
impairment,
depression,
community
participation,
objective
subjective
validation
measures.
Contrary
predictions,
IIV
routine
habits
positive
outcomes.
Many
demographic
technology-related
not
features;
however,
income,
being
native
English
speaker,
season
occupational
status
features.
Conclusions
Theoretically
informed
feasibly
captured
adults’
personal
smartphones
relate
clinically
including
performance,
decline,
mood,
activity.
Future
studies
should
consider
impact
when
interpreting
phenotypes.
is
promising
method
relevant
risk
resilience
context
aging
AD/ADRD
continue
large,
diverse
samples.
Language: Английский
A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease
npj Digital Medicine,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: May 10, 2025
Language: Английский
A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer's disease
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Abstract
Subtle
cognitive
changes
in
preclinical
Alzheimer’s
disease
(AD)
are
difficult
to
detect
using
traditional
pen-and-paper
neuropsychological
assessments.
Remote
and
unsupervised
digital
assessments
can
improve
scalability,
measurement
reliability,
ecological
validity,
enabling
the
detection
monitoring
of
subtle
change.
Here,
we
evaluate
such
tools
deployed
AD
samples,
defined
as
cognitively
unimpaired
individuals
with
abnormal
levels
amyloid-β
(Aβ),
or
Aβ
tau.
In
this
scoping
review,
screened
1,680
unique
reports
for
studies
remote
assessment
samples;
23
were
found.
We
describe
each
tool’s
usability,
reported
metrics
reliability.
Construct
criterion
validity
according
associations
established
measures
tau
reported.
With
aim
present
a
necessary
update
rapidly
evolving
field,
following
previous
review
by
Öhman
colleagues
(2021;
Alzheimers
Dement.
Diagn.
Assess.
Dis.
Monit
)
addressing
open
questions
feasibility
reliability
testing
target
population.
discuss
future
directions
how
may
be
used
longitudinal
function,
scalable
case
finding,
individualized
prognostics
both
clinical
trials
healthcare
contexts.
Language: Английский
Effect of Implementing an Informatization Case Management Model on the Management of Chronic Respiratory Diseases in a General Hospital: Retrospective Controlled Study
JMIR Medical Informatics,
Journal Year:
2024,
Volume and Issue:
12, P. e49978 - e49978
Published: June 19, 2024
The
use
of
chronic
disease
information
systems
in
hospitals
and
communities
plays
a
significant
role
prevention,
control,
monitoring.
However,
there
are
several
limitations
to
these
systems,
including
that
the
platforms
generally
isolated,
patient
health
medical
resources
not
effectively
integrated,
"Internet
Plus
Healthcare"
technology
model
is
implemented
throughout
consultation
process.
Language: Английский
Mobility-Based Smartphone Digital Phenotypes Unobtrusively Capture Everyday Cognition, Mood, and Community Life-Space in Older Adults: A Pilot Study (Preprint)
Katherine Hackett,
No information about this author
Shiyun Xu,
No information about this author
Moira McKniff
No information about this author
et al.
Published: April 29, 2024
BACKGROUND
Current
methods
of
monitoring
cognition
in
older
adults
are
insufficient
to
address
the
growing
burden
Alzheimer
disease
and
related
dementias
(AD/ADRD).
New
approaches
that
sensitive,
scalable,
objective,
reflective
meaningful
functional
outcomes
direly
needed.
Mobility
trajectories
geospatial
life
space
patterns
reflect
many
aspects
cognitive
integrity
may
be
useful
proxies
age-related
decline.
OBJECTIVE
We
investigated
feasibility,
acceptability,
preliminary
validity
a
1-month
smartphone
digital
phenotyping
protocol
infer
everyday
cognition,
function,
mood
from
passively
obtained
GPS
data.
also
sought
clarify
intrinsic
extrinsic
factors
associated
with
mobility
phenotypes
for
consideration
future
studies.
METHODS
Overall,
37
aged
between
63
85
years
healthy
(n=31,
84%),
mild
impairment
(n=5,
13%),
dementia
(n=1,
3%)
used
an
open-source
app
(mindLAMP)
unobtrusively
capture
4
weeks.
data
were
processed
into
interpretable
features
across
categories
activity,
inactivity,
routine,
location
diversity.
Monthly
average
day-to-day
intraindividual
variability
(IIV)
metrics
calculated
each
feature
test
priori
hypotheses
neuropsychological
framework.
Validation
measures
collected
at
baseline
compared
against
monthly
examine
construct
validity.
Feasibility
acceptability
included
retention,
comprehension
study
procedures,
technical
difficulties,
satisfaction
ratings
debriefing.
RESULTS
All
(37/37,
100%)
participants
completed
4-week
period
without
major
adverse
events,
100%
(37/37)
reported
explanation
97%
(36/37)
no
feelings
discomfort.
Participants’
scores
on
consent
quiz
education
race.
Technical
issues
requiring
troubleshooting
infrequent,
though
41%
(15/37)
battery
drain.
Moderate
strong
correlations
(<i>r</i>≥0.3)
identified
validators.
Specifically,
individuals
greater
activity
more
diversity
demonstrated
better
less
impairment,
depression,
community
participation,
objective
subjective
validation
measures.
Contrary
predictions,
IIV
routine
habits
positive
outcomes.
Many
demographic
technology-related
not
features;
however,
income,
being
native
English
speaker,
season
occupational
status
features.
CONCLUSIONS
Theoretically
informed
feasibly
captured
adults’
personal
smartphones
relate
clinically
including
performance,
decline,
mood,
activity.
Future
studies
should
consider
impact
when
interpreting
phenotypes.
is
promising
method
relevant
risk
resilience
context
aging
AD/ADRD
continue
large,
diverse
samples.
Language: Английский
Revisiting Remote Monitoring for Older Adults: A Scoping Review toward Advancing Remote Monitoring for Patients with AD/ADRD (Preprint)
Published: Nov. 23, 2024
BACKGROUND
Background:
Using
remote
monitoring
technology
in
the
context
of
Alzheimer’s
care
presents
exciting
new
opportunities
to
lessen
caregiver
stress
and
improve
patient
quality.
The
application
wearables,
environmental
sensors,
smart
home
systems
designed
specifically
for
patients
represents
a
promising
interdisciplinary
approach
that
integrates
advanced
with
healthcare
enhance
safety,
monitor
health
parameters
real-time,
provide
comprehensive
support
caregivers.
OBJECTIVE
Objective:
objectives
this
paper
include
evaluating
effectiveness
various
sensing
technologies
enhancing
outcomes
identifying
strategies
alleviate
burden
on
professionals
Critical
elements
such
as
regulatory
compliance,
user-centered
design,
privacy
security
considerations,
overall
efficacy
relevant
are
comprehensively
examined.
Ultimately,
study
aims
propose
framework
tailored
needs
Disease
Related
Dementias.
METHODS
Methods:
Guided
by
PRISMA
(Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses)
framework,
we
conducted
systematic
review
Remote
Monitoring
Patients
Dementia.
Our
search
spanned
four
major
electronic
databases—Google
Scholar,
PubMed,
IEEE,
DBLP
February
20,
2024,
an
updated
May
18,
2024.
RESULTS
Results:
A
total
31
publications
met
inclusion
criteria,
highlighting
key
research
areas:
existing
techniques,
balancing
practicality
empathy,
monitoring,
design
care.
studies
revealed
strong
focus
methods
capturing
behavioral,
physiological,
data,
yet
showed
gap
these
patient-caregiver
needs,
privacy,
usability.
Findings
also
indicated
many
lacked
robust
reference
standards
did
not
consistently
apply
critical
appraisal
underlining
need
frameworks
better
integrate
essential
considerations.
CONCLUSIONS
Conclusions:
This
literature
techniques
(AD)
provides
understanding
trends,
gaps
current
significance
novel
reduce
among
proposed
inspire
development
models
advance
AD
patients.
Language: Английский
Revisiting Remote Monitoring for Older Adults: A Systematic Literature Review toward Advancing Remote Monitoring for Patients with AD/ADRD (Preprint)
JMIR Aging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 23, 2024
Language: Английский