Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults DOI Creative Commons
Yutong Pan,

Yamin Li,

Zhaohong Peng

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 28, 2024

Although emerging evidence suggests that indole derivatives, microbial metabolites of tryptophan, may improve cardiometabolic health, the effective remain unclear. Also, gut microbiota involved in producing derivatives are less studied. We identified taxa can predict serum concentrations key metabolite indole-3-propionic acid (IPA) at population level and investigated associations IPA-predicting genera with risk markers. In a cohort 318 community-dwelling adults, fecal (16S ribosomal RNA) were measured baseline. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), fasting blood glucose repeatedly baseline again after 1 year. Brachial-ankle pulse wave velocity (baPWV) ankle-brachial index (ABI) The association between 1-year changes lipids glucose, baPWV ABI using linear regression models. Each µmol/L increase indole-3-acetic (IAA) levels was associated 5.08% (P = 0.046) decrease LDL-C. IPA inversely (percentage difference -1.32%, P 0.036). Per Indole-3-aldehyde (IAld) 1.91% 0.004) TC 0.58% 0.019) ABI, but 1.79% HDL-C borderline significance 0.050). 18 bacterial whose relative abundance positively (PFDR < 0.05) constructed score to reflect overall IPA-producing potential. This -0.48%, 0.007). Our results suggest IAA, IPA, IAld, favorably several markers, although IAld levels.

Language: Английский

Gut microbiota may modify the association between dietary polyphenol intake and circulating levels of hippuric acid: results from a 1-year longitudinal study in China DOI
Yutong Pan, Yang Yang,

Zhaohong Peng

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Validation of a food frequency questionnaire for measuring dietary intake of isoflavones and lignans using the method of triads DOI
Junyi Zhang,

Shaoxian Liang,

Guobing Sun

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Longitudinal association of urinary DHPPA and DHBA with cardiometabolic risk markers in Chinese community-dwelling adults DOI

Yaling Shao,

Zisuo Sun,

Kewan Yin

et al.

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: March 7, 2025

Language: Английский

Citations

0
Perspective: Isoflavones - intriguing molecules but much remains to be learned about these soybean constituents DOI Creative Commons
Mark Messina, Stephen Barnes, Kenneth D.R. Setchell

et al.

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100418 - 100418

Published: March 1, 2025

Isoflavones are naturally occurring compounds found in a wide range of plants, but among commonly consumed foods especially abundant soybeans and derived from this legume. Much the substantial amount research conducted on soy protein over past 30 years is because their isoflavone content. Research interest isoflavones increased dramatically beginning early 1990s as evidence highlighted possible role prevention cancers, including breast, prostate colon cancer. Recognition that preferentially bind to estrogen receptor (ER)β comparison ERα provided conceptual basis for classifying these diphenolic molecules selective modulators. Isoflavone soon greatly expanded beyond cancer include areas such coronary artery disease, bone health, cognitive function vasomotor symptoms menopause. Nevertheless, safety concerns about isoflavones, based primarily results animal studies presumed estrogenic effects, also arose. However, recent work challenges traditional view estrogenicity isoflavones. Furthermore, have largely been refuted by intervention population studies. On other hand, investigation proposed benefits has produced inconsistent data. The small sample size short duration common many trials, combined with marked interindividual differences metabolism, likely contribute conflicting findings. Also, different products employed, which vary not only total amount, relative proportion three soybean form they delivered (glycoside vs aglycone). For those interested exploring justify an intake recommendation ∼50 mg/d, approximately two servings Asian foods.

Language: Английский

Citations

0
(Poly)phenol-gut microbiota interactions and their impact on human health DOI
Xiaohe Liu, Amnah A. Alharbi, Rachel Gibson

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Purpose of review (Poly)phenols are bioactive compounds in plant-based foods with well documented health benefits. Their metabolism dependent on gut microbiota composition, diversity, and function, which modulate their bioavailability physiological effects. This examines recent insights into (poly)phenol-gut interactions, emphasizing relevance mediating benefits mechanisms action. Recent findings studies have identified a high interindividual variability (poly)phenol metabolism, explored microbial-derived metabolites potential benefits, revealed bidirectional influences between (poly)phenols composition. Advances analytical techniques large-scale refined our understanding these but inconsistencies remain linking specific microbial signatures to outcomes. Summary Standardized methodologies long-term needed clarify the impact (poly)phenol-derived human health. Future research should focus personalized targeted nutrition approaches optimize

Language: Английский

Citations

0
Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies DOI Creative Commons
Ana Clara da C. Pinaffi‐Langley, Stefano Tarantini, Norman G. Hord

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1552 - 1552

Published: Dec. 18, 2024

Polyphenols, plant-derived secondary metabolites, play crucial roles in plant stress responses, growth regulation, and environmental interactions. In humans, polyphenols are associated with various health benefits, particularly cardiometabolic health. Despite growing evidence of polyphenols’ health-promoting effects, their mechanisms remain poorly understood due to high interindividual variability bioavailability metabolism. Recent research highlights the bidirectional relationship between dietary gut microbiota, which can influence polyphenol metabolism and, conversely, be modulated by intake. this concise review, we summarized recent advances area, a special focus on isoflavones ellagitannins corresponding metabotypes, effect cardiovascular Human observational studies published past 10 years provide for consistent association metabotypes better risk factors. However, interventional or isolated microbial metabolites indicate that polyphenol–gut microbiota interrelationship is complex not yet fully elucidated. Finally, highlighted pending questions will help identify effective targets intervention precision nutrition, thus maximizing individual responses lifestyle interventions improving human

Language: Английский

Citations

3
Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults DOI Creative Commons
Yutong Pan,

Yamin Li,

Zhaohong Peng

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 28, 2024

Although emerging evidence suggests that indole derivatives, microbial metabolites of tryptophan, may improve cardiometabolic health, the effective remain unclear. Also, gut microbiota involved in producing derivatives are less studied. We identified taxa can predict serum concentrations key metabolite indole-3-propionic acid (IPA) at population level and investigated associations IPA-predicting genera with risk markers. In a cohort 318 community-dwelling adults, fecal (16S ribosomal RNA) were measured baseline. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), fasting blood glucose repeatedly baseline again after 1 year. Brachial-ankle pulse wave velocity (baPWV) ankle-brachial index (ABI) The association between 1-year changes lipids glucose, baPWV ABI using linear regression models. Each µmol/L increase indole-3-acetic (IAA) levels was associated 5.08% (P = 0.046) decrease LDL-C. IPA inversely (percentage difference -1.32%, P 0.036). Per Indole-3-aldehyde (IAld) 1.91% 0.004) TC 0.58% 0.019) ABI, but 1.79% HDL-C borderline significance 0.050). 18 bacterial whose relative abundance positively (PFDR < 0.05) constructed score to reflect overall IPA-producing potential. This -0.48%, 0.007). Our results suggest IAA, IPA, IAld, favorably several markers, although IAld levels.

Language: Английский

Citations

0