Experimental Neurology, Journal Year: 2024, Volume and Issue: 381, P. 114938 - 114938
Published: Aug. 26, 2024
Language: Английский
European Heart Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 30, 2024
Language: Английский
Citations
322
Hypertension, Journal Year: 2022, Volume and Issue: 80(1), P. 22 - 34
Published: Oct. 5, 2022
Hypertension affects a significant proportion of the adult and aging population represents an important risk factor for vascular cognitive impairment late-life dementia. Chronic high blood pressure continuously challenges structural functional integrity cerebral vasculature, leading to microvascular rarefaction dysfunction, neurovascular uncoupling that typically impairs supply. disrupts blood-brain barrier integrity, promotes neuroinflammation, may contribute amyloid deposition Alzheimer pathology. The mechanisms underlying these harmful effects are still focus investigation, but studies in animal models have provided molecular cellular mechanistic insights. Remaining questions relate whether adequate treatment hypertension prevent deterioration function, threshold treatment, most effective antihypertensive drugs. Recent advances biology, advanced brain imaging, detection subtle behavioral phenotypes begun provide insights into critical issues. Importantly, parallel analysis parameters humans is feasible, making it possible foster translational advancements. In this review, we evaluation evidence available experimental examine progress made identify remaining gaps knowledge.
Language: Английский
Citations
128
Hypertension, Journal Year: 2023, Volume and Issue: 81(1), P. 75 - 86
Published: Nov. 29, 2023
Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, found at autopsy over 50% of people aged ≥65 years, spectrum clinical manifestations. It the main cause lacunar stroke major source vascular contributions to cognitive impairment dementia. The brain areas affected are subcortical periventricular white matter deep gray nuclei. Neuropathological sequelae diffuse lesions (seen as hyperintensities on T2-weighted magnetic resonance imaging), ischemic foci (lacunes or microinfarcts), less commonly, microhemorrhages. most form concentric, fibrotic thickening penetrating arteries (up 300 microns outer diameter) termed arteriolosclerosis. Less forms artery atheroma lipohyalinosis (the described by C. Miller Fisher adjacent lacunes). Other microvascular that not reviewed here include amyloid angiopathy venous collagenosis. Here, we review epidemiology, neuropathology, management, genetics, preclinical models, pathogenesis hypertensive disease. Knowledge gaps initiating factors, molecular pathogenesis, relationships between arterial pathology tissue damage, possible reversibility, pharmacological targets, biomarkers. Progress anticipated from multicell transcriptomic proteomic profiling, novel experimental models further target-finding interventional studies.
Language: Английский
Citations
73
Nature Neuroscience, Journal Year: 2023, Volume and Issue: 27(1), P. 63 - 77
Published: Dec. 4, 2023
Language: Английский
Citations
43
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.
Language: Английский
Citations
6
Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 810 - 832
Published: March 14, 2024
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of disease, role circadian biology has been relatively overlooked both preclinical models humans. Although presence daily patterns observed from level genome whole organism, functional structural impact biological rhythms, including such as misalignment, remains poorly defined. Here, we review rhythms systems regulating blood pressure onset, progression, consequences hypertension. There an emphasis on relation vascular end-organ effects that, individually or combination, contribute complex phenotypes cognitive decline loss cardiac brain health. effective treatment options some individuals, control inadequate substantial portion hypertensive population. Greater insight into may form foundation novel more widely molecular therapies interventions help prevention, treatment, management its related pathophysiology.
Language: Английский
Citations
13
Stroke, Journal Year: 2022, Volume and Issue: 54(1), P. 20 - 29
Published: Dec. 21, 2022
Executive function is frequently impaired among people who have sustained stroke. This review provides an overview of definitions, concepts, and measures. The also summarizes current best evidence examining executive impairment recovery trajectories after stroke, correlates change over time, emerging intervention research. Finally, this recommendations for research clinical practices, as well priorities future
Language: Английский
Citations
28
Hypertension, Journal Year: 2023, Volume and Issue: 80(10), P. 2088 - 2098
Published: July 21, 2023
Hypertension and enlarged perivascular spaces (EPVS) are thought to be associated with cognitive impairment. However, the correlations among hypertension, EPVS, impairment have not been studied yet. We aimed investigate relationships between cumulative blood pressure (cBP) exposure EPVS whether may mediate relationship cBP impairment.A total of 1507 subjects from Kailuan prospective cohort study were enrolled. was calculated 2006 2022. The effects cBP, scores, evaluated using a logistic regression model. score, analyzed mediation model.An increase in positively correlated an score. For every SD odds ratios (95% CI) increased score centrum semiovale 1.67 (1.43-1.95), 1.63 (1.4-1.9), 1.35 (1.17-1.56), respectively; basal ganglia 1.83 (1.56-2.15), 2.01 (1.7-2.36), 1.31 (1.13-1.52), developing 1.28 (1.06-1.53), 1.13 (0.95-1.34), (1.07-1.5), respectively. Basal ganglia-EPVS accounted for 10.46% 18.32% mediating on cBP/SD impairment.High independent risk factor mediated impairment.URL: https://www.gov; Unique identifier: ChiCTR-TNRC-11001489.
Language: Английский
Citations
11
Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: 402, P. 578574 - 578574
Published: March 4, 2025
Language: Английский
Citations
0
HYPERTENSION, Journal Year: 2025, Volume and Issue: 17(4), P. 29 - 168
Published: Jan. 29, 2025
No abstract
Citations
0