Experimental Neurology, Journal Year: 2024, Volume and Issue: 381, P. 114938 - 114938
Published: Aug. 26, 2024
Language: Английский
JMIR Research Protocols, Journal Year: 2024, Volume and Issue: 13, P. e56484 - e56484
Published: June 17, 2024
Background Vascular cognitive impairment (VCI) persistently impairs cognition and the ability to perform activities of daily living, seriously compromising patients’ quality life. Previous studies have reported that disorders serum iron metabolism deposition in brain can lead inflammation, abnormal protein aggregation degeneration, massive neuronal apoptosis central nervous system, which turn leads a progressive decline processes. Our previous clinical found acupuncture be safe effective intervention for treating VCI, but specific mechanisms require further exploration. Objective The objective trial is evaluate efficacy Tongdu Xingshen investigate whether it improve VCI by regulating body metabolism. Methods In total, 42 patients with 21 healthy individuals will participate this trial. randomized into control groups, while group. Both groups receive conventional medical treatment rehabilitation training. addition, group electroacupuncture 30 minutes each time, 6 times week 4 weeks. Meanwhile, not any intervention. All 3 undergo baseline assessments deposition, metabolism, neuropsychological tests after enrollment. evaluated again at end weeks treatment, as described earlier. By comparing test scores between we examine VCI. Additionally, correlations scores, indexes explore possible Results Participants are currently being recruited. first participant was enrolled June 2023, marked official start experiment. As submission paper, there were 23 participants. recruitment process expected continue until 2025, point processing analysis data begin. May 15, 2024, up people been Conclusions This study provide on effects cerebral well somatic These results help prove theoretical basis wide application therapy rehabilitation. Trial Registration China Clinical Agency ChiCTR2300072188; https://tinyurl.com/5fcydtkv International Registered Report Identifier (IRRID) PRR1-10.2196/56484
Language: Английский
Citations
1
BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)
Published: Nov. 14, 2024
Abstract Background This study aimed to examine the association between American Heart Association’s (AHA) newly revised Life’s Essential 8 (LE8) algorithm, designed for assessing cardiovascular health (CVH), and cognitive impairment among older adults in United States. Methods employed a cross-sectional design, utilizing data from 2011–2014 National Health Nutrition Examination Survey explore relationship CVH adults. scores are assessed based on AHA definition of LE8, categorized into three tiers: low (0–49), medium (50–79), high (80–100). Cognitive is evaluated using distinct scoring systems: Consortium Establish Registry Alzheimer’s Disease (CERAD), Animal Fluency Test (AFT), Digit Symbol Substitution (DSST). The lowest quartile as cut-off point; below or equal lower was considered population, above normal population. To analyze association, multivariable logistic regression restricted cubic spline (RCS) models were employed. Results A significant negative correlation exists LE8 impairment. After adjusting multiple variables, odds ratios (OR) impairment, measured by CERAD, AFT, DSST, compared patients with CVH. results indicated OR values 0.60 (95% CI: 0.36–0.98), 0.72 0.52–0.97), 0.29 0.16–0.53) respectively. Additionally, RCS curve demonstrated linear lifestyle factors encapsulated Conclusions findings indicate higher adherence associated Furthermore, maintaining optimal crucial preventing
Language: Английский
Citations
1
Journal of the American Geriatrics Society, Journal Year: 2023, Volume and Issue: 72(2), P. 423 - 432
Published: Nov. 2, 2023
Abstract Background Blood pressure (BP) is a dynamic measure that fluctuates over time. However, conventional BP control indicators may not adequately reflect the variability of during period Methods We performed secondary analysis Systolic Pressure Intervention Trial (SPRINT), which compared systolic blood (SBP) targets <120 mmHg (intensive) and <140 (standard) among patients with hypertension high cardiac risks. The target ranges were defined as 110 to 130 in intensive treatment arm 120 140 standard arm, respectively. Time range (TTR) was calculated based on SBP measurements recorded first 3‐month follow‐up using linear interpolation method. Fine‐Gray competing risk regression models used evaluate association between TTR cognitive outcomes. Results A total 7965 mean (SD) age 68.0 (9.2) years included, 35% female. Patients higher younger, more likely be male take <3 BP‐lowering agents. Compared last quartile, quartile significantly associated probable dementia (HR: 1.74; 95% CI: 1.22–2.46; p = 0.002) composite or mild impairment 1.26; 1.03–1.55; 0.025). outcome increased per decrease 1.18; 1.06–1.30; 0.002 HR: 1.07; 1.00–1.14; 0.036). Sensitivity analyses showed similar results after adjusting follow‐up. Conclusions In this SPRINT data, independently hypertension, suggesting could practical metric older adults. Registration URL: https://www.clinicaltrials.gov ; Identifier: NCT01206062.
Language: Английский
Citations
2
Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13
Published: Sept. 1, 2022
Background Although blood pressure variability (BPV) has emerged as a novel risk factor for Alzheimer's disease, few studies have examined the effects of night BPV on brain structure and function. This study investigated association with atrophy cognitive function changes. Methods The analysis included 1,398 participants valid ambulatory (BP) monitoring at baseline both 4-year follow-up magnetic resonance images who were recruited from Korean Genome Epidemiology Study. Participants underwent comprehensive neuropsychological test battery. was derived BP calculated standard deviation (SD) 24-h daytime nighttime BP. Results During median 4.3 years, increased SD systolic or diastolic an indicator total volume reduction, while average not associated High reduced gray matter (GM) volume, independent BP, use antihypertensive drugs. It also reduction temporal GM mostly driven by in left entorhinal cortex right fusiform gyrus. In performance, high decrease visual delayed recall memory verbal fluency category. Conclusion Increased BPV, rather than mean decline. could be predictor rapid aging middle-aged population.
Language: Английский
Citations
3
Experimental Neurology, Journal Year: 2024, Volume and Issue: 381, P. 114938 - 114938
Published: Aug. 26, 2024
Language: Английский
Citations
0