Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Language: Английский

The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study DOI Creative Commons

Yuxin Yan,

Rui La, Ming Jiang

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 7, 2024

Abstract Objectives While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC associated with RA disease events. Methods Data were collected specifically extracted from National Health Nutrition Examination Survey (NHANES) 1999–2008 database. The value was derived by subtracting combined amount of low-density lipoprotein (LDL-C) high-density (HDL-C) total (TC). using multivariate regression analysis subgroup analysis. Results analyzed 7777 patients, 581 patients (7.47%) diagnosed RA. After accounting for different covariates, logistic revealed notable correlation increased levels an likelihood (odds ratio OR = 1.54; 95% confidence interval CI: 1.11–2.13; P 0.0092). interaction test did yield statistically significant effects on association. linear observed within restricted cubic spline model limitations. Conclusion results suggest that higher are odds RA, indicating can serve novel convenient index forecasting in United States. Additionally, these findings offer insights into early intervention strategies susceptible populations at risk developing

Language: Английский

Citations

14
Investigating the impact of remnant cholesterol on new-onset stroke across diverse inflammation levels: Insights from the China Health and Retirement Longitudinal Study (CHARLS) DOI

Chen-Chun Xiong,

Feng Gao, Jianhui Zhang

et al.

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: 405, P. 131946 - 131946

Published: March 7, 2024

Language: Английский

Citations

10
Remnant cholesterol traits and risk of stroke: A multivariable Mendelian randomization study DOI Creative Commons
Zhiyuan Wu, Yue Jiang, Zheng Guo

et al.

PNAS Nexus, Journal Year: 2024, Volume and Issue: 3(2)

Published: Feb. 1, 2024

Abstract Observational epidemiological studies have reported a relationship between remnant cholesterol and stroke. However, the results are inconclusive, causality remains unclear due to confounding or reverse causality. Our objective in this study was investigate causal relevance of risk stroke its subtypes using Mendelian randomization (MR) approach. Genome-wide association (GWASs) including 115,082 European individuals (UK Biobank) were used identify instruments for cholesterol, intermediate-density lipoprotein (IDL) very-low-density (VLDL) cholesterol. Summary-level data total stroke, intracerebral hemorrhage, subarachnoid ischemic (IS), IS obtained from GWAS meta-analyses conducted by MEGASTROKE consortium. Univariable multivariable MR analyses performed. The identified multiple single-nucleotide polymorphisms after clumping (n = 52), IDL 62), VLDL 67). Assessed individually MR, (weighted median: odds ratio [OR] 1.32 per 1-SD higher trait; 95% CI: 1.04–1.67; P 0.024) had effect estimates consistent with LAS-IS, driven (OR 1.32; 1.04–1.68; 0.022). In 1.46; 1.10–1.93; 0.009) retained robust on LAS-IS controlling high-density analysis did not indicate associations other subtypes. This suggests that is causally associated

Language: Английский

Citations

8
Cumulative exposure to high remnant-cholesterol concentrations increases the risk of cardiovascular disease in patients with hypertension: a prospective cohort study DOI Creative Commons
Weiqiang Wu,

Guanzhi Chen,

Kuang-Yi Wu

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 21, 2023

Abstract Background The relationship of cumulative remnant-cholesterol (Cum-RC) concentration with the risk cardiovascular disease (CVD) in patients hypertension remains unclear. Methods We studied data for 28,698 individuals whom three consecutive total cholesterol, high-density lipoprotein-cholesterol (HDL-C), and triglyceride concentrations were available, who did not have CVD (14,349 14,349 without), that was collected between 2006 2010. Participants placed into four groups based on Cum-RC quartile: a Q1 group (< 26.40 mg/dl), Q2 (26.40–39.56 Q3 (39.57–54.65 Q4 (≥ 54.66 mg/dl). Cox proportional hazards models used to evaluate CVD. Results Over median 10.9 (interquartile range, 10.5–11.3) years, 1,444 participants developed After adjustment multiple potential confounding factors, compared hypertension, adjusted hazard ratios Q2–Q4 1.07(0.92,1.26), 1.08(0.91,1.28), 1.26(1.03,1.54) ( P = 0.0405); those myocardial infarction 1.51(1.00,2.31), 2.02(1.22,3.27), 2.08(1.41,3.28) < 0.0001); ischemic stroke 1.02(0.84,1.24), 1.04(0.86,1.25), 1.29(1.02,1.62), respectively 0.0336). However, no significant found hemorrhage stroke. At same Cum-RC, significantly higher than without. Conclusions A consistently high increases hypertension. Therefore, achievement blood pressure RC targets should help reduce

Language: Английский

Citations

17
The association between vitamin E intake and remnant cholesterol, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in US adults: a cross-sectional study DOI Creative Commons
Yuxuan Wang, Hao Li, Zhihao Zhang

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

Citations

6
Remnant cholesterol in patients admitted for acute coronary syndromes DOI
Alberto Cordero, Belén Álvarez Álvarez, David Escribano

et al.

European Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 30(4), P. 340 - 348

Published: Dec. 23, 2022

Abstract Background Remnant cholesterol has been identified as one of leading lipid values associated with the incidence coronary heart disease. There is scarce evidence on its distribution and prognostic value in acute syndrome (ACS) patients. Methods results We included all consecutive patients admitted for ACS two different centres. was calculated by equation: total minus LDL HDL cholesterol, ≥30 were considered high. Among 7479 patients, median remnant level 28 mg/dL (21–39), 3429 (45.85%) had levels mg/dL. Age (r: −0.29) body mass index 0.44) variables more strongly correlated. At any given age, overweigh or obesity higher levels. In-hospital mortality 3.75% (280 patients). not to in-hospital risk (odds ratio: 0.89; P = 0.21). After discharge (median follow-up 57 months), an independent linear all-cause failure (HF) observed. &gt;60 [hazard ratio (HR): 1.49 95% CI 1.08–2.06; 0.016], cardiovascular (HR: 0.016), HF re-admission (sub-HR: 1.55 1.14–2.11; 0.005). Conclusions Elevated highly prevalent inversely correlated age positively index. risk, but they long-term HF.

Language: Английский

Citations

23
Remnant cholesterol in atherosclerotic cardiovascular disease: A systematic review and meta-analysis DOI Creative Commons

Dimitrios Delialis,

Georgios Georgiopoulos, Evmorfia Aivalioti

et al.

Hellenic Journal of Cardiology, Journal Year: 2023, Volume and Issue: 74, P. 48 - 57

Published: April 27, 2023

Accumulating evidence suggests a substantial contribution of remnant cholesterol (RC) to residual risk for the development or relapse atherosclerotic cardiovascular disease (ASCVD). We aimed evaluate association RC levels with ASCVD by different categories and methods assessment. also assessed available effects lipid-lowering therapies (LLTs) on levels.English-language searches Medline, PubMed, Embase (inception 31 January 2023); ClinicalTrials.gov (October 2022); reference lists studies reviews. Studies reporting composite endpoint [all-cause mortality, major adverse cardiac events (MACE)] were included. Moreover, we searched differences in after administration LLT(s).Among n = 29 257,387 participants, found pooled linear (pooled HR: 1.27 per 1-SD increase, 95% CI: 1.12-1.43, P < 0.001, I2 95%, 15 studies) non-linear 1.59 quartile 1.35-1.85, 87.9%, M ACE both patients without established ASCVD. Interestingly, MACE was higher directly measured vs. calculated levels. In limited number LLTs reduced levels.RC are associated primary secondary prevention. Directly more evidently. Available tend decrease levels, although clinical relevance merits further investigation.CRD42022371346.

Language: Английский

Citations

13
Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease DOI
Zhiwen Xiao,

Zhongqiu Lin,

Lin Xu

et al.

European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(17), P. 1924 - 1934

Published: Sept. 14, 2023

Abstract Aims Remnant cholesterol (RC) reportedly mediates residual cardiovascular risk in atherosclerotic diseases (ASCVD). However, few studies have characterized long-term cumulative RC exposure among elderly people. The study aimed to evaluate the association between and incident major adverse events (MACE) by analysing a cohort of patients with ASCVD. Methods results This retrospective multicentre enrolled ASCVD participants aged ≥75 years baseline visits occurring from 2006 2012 followed four in-person visits. Cumulative was estimated as area under curve using measurements first fourth 9-year data. time-weighted average (TWA) expressed averaged years. All outcomes were follow-up visit year 2021. Outcomes included composite MACE (stroke, unstable angina pectoris, myocardial infarction, cardiac death). We 4,680 (73.1% male, mean age 79.3 ± 2.5 years). median duration 6.1 (interquartile range: 3.4–6.6 In multivariable model adjusted for traditional factors, low-density lipoprotein level, most recent hazard ratios that compared high low tertiles variables 1.30 [95% confidence interval (CI), 1.16–1.44] 1.36 (95% CI, 1.23–1.52) TWA RC. Consistent significant associations observed propensity score analyses. Conclusions Long-term independently associated ASCVD, suggesting achieving maintaining optimal levels later life may still improve outcomes.

Language: Английский

Citations

13
Remnant cholesterol and intensive blood pressure control in older patients with hypertension: a post hoc analysis of the STEP randomized trial DOI
Ruixue Yang, Juyan Zhang,

Xiaoxu Yu

et al.

European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 31(8), P. 997 - 1004

Published: Jan. 2, 2024

Emerging evidence shows a close relationship between remnant cholesterol (RC) and hypertension. However, it is unknown whether RC associated with the effects of intensive systolic blood pressure (SBP) lowering on cardiovascular outcomes.

Language: Английский

Citations

5
Separate and Joint Associations of Remnant Cholesterol Accumulation and Variability With Carotid Atherosclerosis: A Prospective Cohort Study DOI Creative Commons

Jinqi Wang,

Rui Jin,

Xiaohan Jin

et al.

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(14)

Published: July 14, 2023

Background We aimed to examine separate and joint associations of remnant cholesterol (RC) accumulation variability with the risk carotid atherosclerosis (CAS) in general population. Methods Results A total 6213 participants who underwent 3 sequential health examinations during 2010 2015 were enrolled followed up until December 31, 2021. Cumulative RC (cumRC) among visits exposure interest our study. Adjusted Cox models performed calculate hazard ratio (HR) 95% CI. C‐statistics, integrated discrimination improvement, net reclassification index used estimate incremental predictive ability. During a median follow‐up 4.00 years, 2613 developed CAS. Higher cumRC (HR, 1.33 [95% CI, 1.17–1.52]) greater 1.22 1.08–1.39]) significantly associated elevated CAS, independent traditional cardiovascular factors low‐density lipoprotein cholesterol. Participants divided into 4 groups according assess their associations. Compared “low low variability,” “high high variability” had highest by variability.” Finally, assessment effect on value CAS versus single‐time‐point measures RC. Conclusions Excessive levels each independently higher incidence coexistence could further yield risks.

Language: Английский

Citations

12