Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats DOI Creative Commons
Sana Khan, Yixiang Huang,

Derin Timuçin

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(8), P. ENEURO.0291 - 24.2024

Published: Aug. 1, 2024

Volatile anesthetics are currently believed to cause unconsciousness by acting on one or more molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Anesthetic gases isoflurane bind microtubules (MTs) dampen their quantum optical effects, potentially contributing causing unconsciousness. This possibility is supported the finding that taxane chemotherapy consisting of MT-stabilizing drugs reduces effectiveness anesthesia during surgery in human cancer patients. In order experimentally assess contribution MTs as functionally relevant volatile anesthetics, we measured latencies loss righting reflex (LORR) under 4% male rats injected subcutaneously with vehicle 0.75 mg/kg brain-penetrant drug epothilone B (epoB). EpoB-treated took an average 69 s longer become unconscious latency LORR. was a statistically significant difference corresponding standardized mean (Cohen's

Language: Английский

Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats DOI Creative Commons
Sana Khan, Yixiang Huang,

Derin Timuçin

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(8), P. ENEURO.0291 - 24.2024

Published: Aug. 1, 2024

Volatile anesthetics are currently believed to cause unconsciousness by acting on one or more molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Anesthetic gases isoflurane bind microtubules (MTs) dampen their quantum optical effects, potentially contributing causing unconsciousness. This possibility is supported the finding that taxane chemotherapy consisting of MT-stabilizing drugs reduces effectiveness anesthesia during surgery in human cancer patients. In order experimentally assess contribution MTs as functionally relevant volatile anesthetics, we measured latencies loss righting reflex (LORR) under 4% male rats injected subcutaneously with vehicle 0.75 mg/kg brain-penetrant drug epothilone B (epoB). EpoB-treated took an average 69 s longer become unconscious latency LORR. was a statistically significant difference corresponding standardized mean (Cohen's

Language: Английский

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