American Journal of Respiratory and Critical Care Medicine, Journal Year: 2023, Volume and Issue: 209(6), P. 683 - 692
Published: Dec. 6, 2023
Small airway disease is an important pathophysiological feature of chronic obstructive pulmonary (COPD). Recently, "pre-COPD" has been put forward as a potential precursor stage COPD that defined by abnormal spirometry findings or significant emphysema on computed tomography (CT) in the absence airflow obstruction.
Language: Английский
European Respiratory Journal, Journal Year: 2023, Volume and Issue: 61(4), P. 2300239 - 2300239
Published: March 1, 2023
Executive summary of the Global Strategy for Prevention, Diagnosis and Management COPD 2023: latest evidence-based strategy document from Initiative Chronic Obstructive Lung Disease (GOLD) https://bit.ly/3KCaTGe
Language: Английский
Citations
672
The Lancet, Journal Year: 2022, Volume and Issue: 400(10356), P. 921 - 972
Published: Sept. 1, 2022
Language: Английский
Citations
364
American Journal of Respiratory and Critical Care Medicine, Journal Year: 2023, Volume and Issue: 207(7), P. 819 - 837
Published: March 1, 2023
Language: Английский
Citations
344
American Journal of Respiratory and Critical Care Medicine, Journal Year: 2022, Volume and Issue: 206(11), P. 1317 - 1325
Published: Aug. 1, 2022
"Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision." American Journal Respiratory Critical Care Medicine, 206(11), pp. 1317–1325
Language: Английский
Citations
292
The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 10(5), P. 512 - 524
Published: April 12, 2022
Language: Английский
Citations
191
American Journal of Respiratory and Critical Care Medicine, Journal Year: 2021, Volume and Issue: 205(3), P. 275 - 287
Published: Oct. 21, 2021
Chronic obstructive pulmonary disease (COPD) is the end result of a series dynamic and cumulative gene-environment interactions over lifetime. The evolving understanding COPD biology provides novel opportunities for prevention, early diagnosis, intervention. To advance these concepts, we propose therapeutic trials in two major groups subjects: "young" individuals with those pre-COPD. Given that lungs grow to about 20 years age begin at approximately 50 years, consider patients range 20-50 years. Pre-COPD relates any who have respiratory symptoms or without structural and/or functional abnormalities, absence airflow limitation, may develop persistent limitation time. We exclude from current discussion infants adolescents because their unique physiological context older adults given representation prior randomized controlled (RCTs). highlight need RCTs focused on young pre-COPD reduce progression, providing innovative approaches identifying engaging potential study subjects. detail RCT design, including outcomes such as lung function, patient-reported outcomes, exacerbations, imaging, mortality, composite endpoints. critically review design components statistical powering analysis, duration treatment, formats trial structure, platform, basket, umbrella trials. provide call action treatment
Language: Английский
Citations
112
The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2022, Volume and Issue: 10(11), P. 2783 - 2797
Published: May 7, 2022
Globally, around half the adult asthma population are current or former cigarette smokers. Cigarette smoking and interact to induce an "asthma-smoking phenotype(s)," which has important implications for diagnosis, pathogenic mechanisms, management. The lack of progress in understanding effects on adults with is due part their exclusion from most investigative studies large clinical trials. In this review, we summarize adverse outcomes associated asthma, highlight challenges diagnosing among smokers chronic respiratory symptoms, particularly older individuals a long-standing history, review mechanisms involving smoking- asthma-related airway inflammation, tissue remodeling, corticosteroid insensitivity, low-grade systemic inflammation. We discuss key components management including importance cessation strategies, evidence effectiveness Global Initiative Asthma recommendations treatment smokers, role treatable traits such as type 2 eosinophilic Lastly, provide algorithm aid clinicians manage asthma. future, controlled pragmatic trials real-world populations should include base recommendations.
Language: Английский
Citations
84
The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 11(3), P. 273 - 282
Published: Oct. 14, 2022
Language: Английский
Citations
79
Archivos de Bronconeumología, Journal Year: 2023, Volume and Issue: 59(4), P. 232 - 248
Published: March 1, 2023
Language: Английский
Citations
65
Nature Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 1750 - 1759
Published: June 22, 2023
Language: Английский
Citations
45