Airway bacterial microbiome signatures correlate with occupational pneumoconiosis progression DOI Creative Commons
Huimin Ma, Zheng Dong, Xu Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116875 - 116875

Published: Aug. 13, 2024

Recent evidence has pinpointed a key role of the microbiome in human respiratory health and disease. However, significant knowledge gaps still exist regarding connection between bacterial communities adverse effects caused by particulate matters (PMs). Here, we characterized along different airway sites occupational pneumoconiosis (OP) patients. The sequencing data revealed that OP patients exhibited distinct dysbiosis composition function microbiota. To extents, there was an overall increase colonization microbiota, such as Streptococcus, implying possible intrusion pathway provided exogenous PMs. Compared to those healthy subjects, unhealthy living habits (i.e., smoking) had greater impact on changes Importantly, associations community disease indicators indicated specific species, including Prevotella, Actinobacillus, Leptotrichia, might be surrogate markers progression. Collectively, our results highlighted potential participation microbiota pathogenesis diseases helped discovery microbiome-based diagnostics for PM-induced disorders.

Language: Английский

The pathobiology of human fungal infections DOI
Gordon D. Brown, Elizabeth R. Ballou, Steven Bates

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 687 - 704

Published: June 25, 2024

Language: Английский

Citations

28
Environmental Toxicant Exposure and Depressive Symptoms DOI Creative Commons
Jianhui Guo, Eric Garshick, Feifei Si

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2420259 - e2420259

Published: July 3, 2024

Importance Recognizing associations between exposure to common environmental toxicants and mental disorders such as depression is crucial for guiding targeted mechanism research the initiation of disease prevention efforts. Objectives To comprehensively screen assess potential depressive symptoms whether systemic inflammation serves a mediator. Design, Setting, Participants A total 3427 participants from 2013-2014 2015-2016 waves National Health Nutrition Examination Survey who had information on blood or urine concentrations scores assessed by 9-item Patient Questionnaire (PHQ-9) were included. Statistical analysis was performed July 1, 2023, January 31, 2024. Exposures Sixty-two in 10 categories included acrylamide, arsenic, ethylene oxide, formaldehyde, iodine, metals, nicotine metabolites, polycyclic aromatic hydrocarbons, volatile organic compound (VOC) metabolites; perchlorate, nitrate, thiocyanate. Main Outcomes Measures An exposome-wide association study deletion-substitution-addition algorithm used with (PHQ-9 ≥5) adjusted other important covariates. mediation framework evaluate mediating role peripheral white cell count. Results Among adults included, 1735 (50.6%) women, 2683 (78.3%) younger than 65 years, 744 (21.7%) years older, 839 (24.5%) having symptoms. In terms race ethnicity, 570 (16.6%) Mexican American, 679 (19.8%) non-Hispanic Black, 1314 (38.3%) White. We identified 27 chemical compounds metals 6 prevalence symptoms, including VOC metabolites N -acetyl- S -(2-hydroxy-3-butenyl)- l -cysteine (odds ratio [OR], 1.74 [95% CI, 1.38, 2.18]) equivalent-2 (OR, 1.42 1.26-1.59]). Men individuals appear more vulnerable women older individuals. Peripheral count mediated 5% 19% associations. Conclusions Relevance this representative cross-sectional toxicant exposures, associated inflammation. This provides insight into selecting targets mechanistic causes facilitating efforts reduce exposures.

Language: Английский

Citations

21
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

Citations

20
Lung Microbiota: From Healthy Lungs to Development of Chronic Obstructive Pulmonary Disease DOI Open Access
Marija Stanković

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1403 - 1403

Published: Feb. 7, 2025

Lung health is dependent on a complex picture of the lung microbiota composed bacteriobiota, mycobiota, and virome. The studies have demonstrated that has crucial role in host protection by regulating innate adaptive immunity. Chronic obstructive pulmonary disease (COPD) an inflammatory featuring changed composition diversity, known as dysbiosis. dysbiosis increases with progress COPD during exacerbation. Two models been proposed: inflammation cycles disturbance bacterial interactome. Still, it unknown if driving factor pathogenesis belongs to or microbiota. Recently, host–microbiota microbe–microbe interactions highlighted COPD, but mechanisms behind these need further exploration. function gut–lung axis for maintenance affected COPD. application probiotics resulted host–beneficial effects, likely future this field will aid therapy In review, microbiota, molecular mechanisms, clinical aspects relating are comprehensively provided.

Language: Английский

Citations

1
Bibliometric analysis of intestinal microbiota and lung diseases DOI Creative Commons

Wei‐Ting Sun,

Tong Zhou, Peng Ding

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 15, 2024

Background Increasing evidence suggests a close association between the intestinal microbiome and respiratory system, drawing attention to studying gut-lung axis. This research employs bibliometric methods conduct visual analysis of literature in field microbiota lung diseases over past two decades. It offers scientific foundations for directions critical issues this field. Methods We retrieved all articles on from SCI-Expanded WoSCC October 25, 2023. The included original reviews published English 2011 utilized Python, VOSviewer, CiteSpace analyze data visually. Results A total 794 publications were analyzed. China ranked first number publications, while United States had highest citations H-index. Jian Wang was most prolific author. Zhejiang University institution with publications. Frontiers Microbiology journal Author keywords appearing more than 100 times “intestinal microbiota/microbiome”, “microbiota/microbiome”, “gut-lung axis”. Conclusion correlation underlying mechanisms diseases, including asthma, COPD, cancer, infections, remain hot topics research. However, understanding involving axis is still its infancy requires further elucidation.

Language: Английский

Citations

6
A multi-omics investigation of the lung injury induced by PM2.5 at environmental levels via the lung-gut axis DOI
Shuiping Dai, Zhenglu Wang, Min Cai

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 172027 - 172027

Published: March 27, 2024

Language: Английский

Citations

5
Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease DOI Creative Commons

Jingyuan Gao,

Yuqiong Yang,

Xiaopeng Xiang

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: April 16, 2024

Little is known about the relationships between human genetics and airway microbiome. Deeply sequenced metagenomics, by simultaneously characterizing microbiome host genetics, provide a unique opportunity to assess microbiome-host genetic associations. Here we performed co-profiling of with identification over 5 million single nucleotide polymorphisms (SNPs) through deep metagenomic sequencing in sputum 99 chronic obstructive pulmonary disease (COPD) 36 healthy individuals. Host variation was most significant factor associated except for geography status, its top principal components accounting 12.11% variability. Within COPD individuals, 113 SNPs mapped candidate genes reported as genetically exhibited associations 29 microbial species 48 functional modules (P < 1 × 10

Language: Английский

Citations

4
The capacity of human interventions to regulate PM2.5 concentration has substantially improved in China DOI Creative Commons

Jiachen Meng,

Wenchao Han,

Cheng Yuan

et al.

Environment International, Journal Year: 2025, Volume and Issue: 195, P. 109251 - 109251

Published: Jan. 1, 2025

The rapid urbanization in China has brought about serious air pollution problems, which are likely to persist for a considerable period as the process continues. In urban areas, spatial distribution of pollutants represented by PM

Language: Английский

Citations

0
Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome DOI Creative Commons

Menghui Jiang,

Yongwei Yan,

Tao Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117857 - 117857

Published: Feb. 1, 2025

The detrimental effects of diesel engine exhaust (DEE) on public health are receiving increasing attention, particularly concerning respiratory health. Our understanding the associations airway bacterial ecosystem with exposure to DEE and remains limited. study aimed identify signature assess its correlation in occupational populations. In this study, we collected induced sputum from 54 diesel-exposed workers 52 unexposed controls. exposed participants experienced lower forced vital capacity (FVC) expiratory volume one second (FEV1) than Importantly, overall assemblage individuals differed significantly relative abundance Prevotella nanceiensis, shahii, Aggregatibacter segnis, Lachnoanaerobaculum umeaense displayed remarkable differences between two groups. Furthermore, showed a less robust network fewer keystone species their bacteriome Spearman analysis indicated notable correlations specific carbon content macrophages (CCAM), club cell protein (CC16), FVC FEV1. Taken together, our provided new information difference under supported potential link lung function

Language: Английский

Citations

0
The Role of Inflammation in the Pathogenesis of Comorbidity of Chronic Obstructive Pulmonary Disease and Pulmonary Tuberculosis DOI Open Access
Stanislav Kotlyarov, Д. Н. Оськин

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2378 - 2378

Published: March 7, 2025

The comorbid course of chronic obstructive pulmonary disease (COPD) and tuberculosis is an important medical social problem. Both diseases, although having different etiologies, have many overlapping relationships that mutually influence their prognosis. aim the current review to discuss role immune mechanisms underlying inflammation in COPD tuberculosis. These are known involve both innate adaptive system, including various cellular intercellular interactions. There growing evidence involved pathogenesis may jointly contribute tuberculosis-associated (TOPD) phenotype. Several studies reported prior as a risk factor for COPD. Therefore, study link considerable clinical interest.

Language: Английский

Citations

0