BMC Biology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: June 15, 2022
Abstract
Background
Circadian
rhythms
are
important
for
all
aspects
of
biology;
virtually
every
aspect
biological
function
varies
according
to
time
day.
Although
this
is
well
known,
variation
across
the
day
also
often
ignored
in
design
and
reporting
research.
For
review,
we
analyzed
top
50
cited
papers
10
major
domains
sciences
calendar
year
2015.
We
repeated
analysis
2019,
hypothesizing
that
awarding
a
Nobel
Prize
2017
achievements
field
circadian
biology
would
highlight
importance
scientists
many
disciplines,
improve
time-of-day
reporting.
Results
Our
analyses
these
1000
empirical
papers,
however,
revealed
most
failed
include
sufficient
temporal
details
when
describing
experimental
methods
few
systematic
differences
existed
between
2015
2019.
Overall,
only
6.1%
reports
included
information
about
measures
manipulations
permit
replication.
Conclusions
defining
feature
systems,
knowing
systems
evaluated
fundamentally
information.
Failing
account
hampers
reproducibility
laboratories,
complicates
interpretation
results,
reduces
value
data
based
predominantly
on
nocturnal
animals
extrapolating
diurnal
humans.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11714 - 11714
Published: Oct. 28, 2021
Tryptophan
is
an
essential
amino
acid
whose
metabolites
play
key
roles
in
diverse
physiological
processes.
Due
to
low
reserves
the
body,
especially
under
various
catabolic
conditions,
tryptophan
deficiency
manifests
itself
rapidly,
and
both
serotonin
kynurenine
pathways
of
metabolism
are
clinically
significant
critically
ill
patients.
In
this
review,
we
highlight
these
as
sources
melatonin,
which
then
regulate
neurotransmission,
influence
circadian
rhythm,
cognitive
functions,
development
delirium.
Kynurenines
serve
important
signaling
functions
inter-organ
communication
modulate
endogenous
inflammation.
Increased
plasma
levels
kynurenine-tryptophan
ratios
early
indicators
for
sepsis.
They
also
regulation
skeletal
muscle
mass
thereby
polyneuromyopathy
The
modulation
could
help
prevent
treat
age-related
disease
with
grade
chronic
inflammation
well
post
intensive
care
syndrome
all
its
varied
manifestations:
decline
(including
delirium
or
dementia),
physical
impairment
(catabolism,
protein
breakdown,
loss
tone),
mental
(depression,
anxiety
post-traumatic
stress
disorder).
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(5), P. 2654 - 2654
Published: Feb. 28, 2022
COVID-19,
resulting
from
the
SARS-CoV-2
virus,
is
a
major
pandemic
that
world
fighting.
primarily
causes
lung
infection
by
attaching
to
ACE2
receptor
on
alveolar
epithelial
cells.
However,
also
present
in
intestinal
cells,
suggesting
link
between
nutrition,
virulence
and
clinical
outcomes
of
COVID-19.
Respiratory
viral
infections
perturb
gut
microbiota.
The
microbiota
shaped
our
diet;
therefore,
healthy
important
for
optimal
metabolism,
immunology
protection
host.
Malnutrition
diverse
changes
immune
system
repressing
responses
enhancing
vulnerability.
Thus,
improving
health
with
high-quality,
nutrient-filled
diet
will
improve
immunity
against
diseases.
This
review
emphasizes
significance
dietary
choices
its
subsequent
effects
system,
which
may
potentially
impact
BMC Biology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: June 15, 2022
Abstract
Background
Circadian
rhythms
are
important
for
all
aspects
of
biology;
virtually
every
aspect
biological
function
varies
according
to
time
day.
Although
this
is
well
known,
variation
across
the
day
also
often
ignored
in
design
and
reporting
research.
For
review,
we
analyzed
top
50
cited
papers
10
major
domains
sciences
calendar
year
2015.
We
repeated
analysis
2019,
hypothesizing
that
awarding
a
Nobel
Prize
2017
achievements
field
circadian
biology
would
highlight
importance
scientists
many
disciplines,
improve
time-of-day
reporting.
Results
Our
analyses
these
1000
empirical
papers,
however,
revealed
most
failed
include
sufficient
temporal
details
when
describing
experimental
methods
few
systematic
differences
existed
between
2015
2019.
Overall,
only
6.1%
reports
included
information
about
measures
manipulations
permit
replication.
Conclusions
defining
feature
systems,
knowing
systems
evaluated
fundamentally
information.
Failing
account
hampers
reproducibility
laboratories,
complicates
interpretation
results,
reduces
value
data
based
predominantly
on
nocturnal
animals
extrapolating
diurnal
humans.
