The nutritional status of mycetoma affected patients seen at the Mycetoma Research Center, Sudan DOI Creative Commons

Manal Hassan Gabani,

Arwa Abdelraouf Ahmed,

Alshaima Abdelelah Hassan

et al.

PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(1), P. e0011726 - e0011726

Published: Jan. 2, 2024

Nutrition plays a critical and crucial role in addressing neglected tropical diseases (NTDs) their complications, as they often contribute to malnutrition, which can worsen the impact of these conditions. Therefore, it is necessary investigate nutritional status mycetoma patients, has not been explored previously. This descriptive cross-sectional hospital-based study was conducted at Mycetoma Research Center (MRC), University Khartoum, Sudan. The included 179 confirmed patients an equal number age- sex-matched normal controls. assessed compared with that control group. majority were young adults varying educational levels, predominantly from Central foot most commonly affected part; had lesions more than 10 cm diameter. Body Mass Index (BMI) calculated for both groups, revealing 43.5% 53.6% controls BMI. Furthermore, 36% underweight, contrasting only 11% Correlation analyses indicated no significant associations between BMI age daily meals, food quantity, appetite population ( p > 0.05). Similarly, differences observed concerning disease duration sites = 0.0577). Kruskal-Wallis test did reveal means among groups. revealed participants consumed three meals daily, group showed robust patient 0.005). Nevertheless, there consumption different types groups categories 0.025 0.040, respectively).

Language: Английский

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors DOI Creative Commons
Levente Zsichla, Viktor Müller

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 175 - 175

Published: Jan. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Language: Английский

Citations

70
Understanding the omicron variant (B.1.1.529) of SARS-CoV-2: Mutational impacts, concerns, and the possible solutions DOI Open Access
Fahadul Islam, Manish Dhawan, Mohamed H. Nafady

et al.

Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 78

Published: May 7, 2022

Despite many nations' best efforts to contain the so-called COVID-19 pandemic, emergence of SARS-CoV-2 Omicron strain (B.1.1.529) has been identified as a serious concern. After more than two years pandemic and year worldwide vaccination efforts, globe will not be free variants such Delta variants. According current statistics, variant 30 mutations when contrasted other VOCs Alpha (B.1.1.7), Beta (B.1.351), (B.1.617.2). High numbers changes, particularly in spike protein (S-Protein), raise worries about virus's capacity resist pre-existing immunity acquired by or spontaneous infection antibody-based therapy. The raised international concerns, resuming travel bans coming up with questions its severity, transmissibility, testing, detection, vaccines efficiency against it. Additionally, inadequate health care infrastructures immunocompromised individuals increase susceptibility. status low rates play significant role omicron spreading create fertile ground for producing new As result, this article emphasizes mutational changes their consequences. In addition, potential preventing measures have examined detail.

Language: Английский

Citations

47
Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis DOI Creative Commons
Pegah Khales, Mohammad Hossein Razizadeh, Saied Ghorbani

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 9, 2024

Abstract Purpose Human adenoviruses (HAdVs) have always been suggested as one of the main causes gastroenteritis in children. However, no comprehensive report on global epidemiology these viruses pediatric is available. Methods A systematic search was conducted to obtain published papers from 2003 2023 three databases PubMed, Scopus, and Web Science. Results The estimated pooled prevalence HAdV infection children with 10% (95% CI: 9-11%), a growing trend after 2010. highest observed Africa (20%, 95% 14–26%). higher inpatients (11%; 8-13%) patients aged 5 years old younger (9%; 7-10%). significant difference between male female ( P = 0.63). most prevalent species found be F (57%; 41-72%). common HAdVs were types 40/41, 38, 2. Analysis case-control studies showed an association (OR: 2.28, CI; 1.51–3.44). Conclusion This study provided valuable insights into importance gastroenteritis, especially hospitalized results can used future preventive measurements development effective vaccines.

Language: Английский

Citations

6
What Makes the Gut-Lung Axis Working? From the Perspective of Microbiota and Traditional Chinese Medicine DOI Creative Commons
Hui Wang, Ying Wang

Canadian Journal of Infectious Diseases and Medical Microbiology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 15

Published: Jan. 18, 2024

Background. An increasing number of studies have proved that gut microbiota is involved in the occurrence and development various lung diseases can interact with diseased lung. The concept gut-lung axis (GLA) provides a new idea for subsequent clinical treatment through human microbiota. This review aims to summarize interaction between them from perspectives traditional Chinese medicine modern medicine. Method. We conducted literature search by using terms “GLA,” “gut microbiota,” “spleen,” “Chinese medicine” databases PubMed, Web Science, CNKI. then explored mechanism action Results. enable GLA function immune regulation, while metabolites also play an important role. spleen improve achieve regulation GLA. Conclusion. Improving qi supplementation fortification approach regulating Currently, our understanding limited, more research needed explain its working principle.

Language: Английский

Citations

5
Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review DOI Creative Commons
Zahra Salehi, Mohammadreza Askari, Alireza Jafari

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 21, 2024

COVID-19 is a pandemic caused by nCoV-2019, new beta-coronavirus from Wuhan, China, that mainly affects the respiratory system and can be modulated nutrition.

Language: Английский

Citations

4
Household income and nutrient adequacy in women of reproductive age: A study in Babakan Village, Indonesia DOI Creative Commons
Resa Ana Dina,

Fidela Nailan Faza Prasetyaji

BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 153, P. 02023 - 02023

Published: Jan. 1, 2025

Background: The condition of Chronic Energy Deficiency and anemia often occurs in women reproductive age can lead to health problems. Objective: This research aims examine the relationship between household income adequacy energy, protein, iron levels Babakan Village. Methods: employs a cross-sectional design. respondents are 78 age, residing Village, determined using purposive sampling. instruments this include interview questionnaires (household characteristics) 1x24-hour food recall forms (levels adequacy). Hypothesis testing uses Spearman test determine levels. Results: results indicate significant with value p < 0.05, while there is no income, protein > 0.05. Conclusion: study indicates that higher may improve access nutritious foods but does not ensure better nutrient population.

Language: Английский

Citations

0
Impact of Marasmic Malnutrition on Visceral Leishmaniasis: Progression and Treatment Efficacy in a Murine Model DOI Open Access
Taiana Ferreira-Paes, Luiza F. O. Gervazoni,

Paula Seixas-Costa

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 849 - 849

Published: Feb. 28, 2025

Malnutrition and visceral leishmaniasis are major public health problems that responsible for millions of deaths across many countries. Leishmaniasis development progression associated with the host immune status. In this context, malnutrition can directly affect course leishmaniasis, impairing several components system. Moreover, interferes tropism Leishmania in organs, affecting susceptibility. Therefore, work aimed to evaluate influence nutritional status on establishment, progression, treatment infantum infection malnourished refed mice. BALB/c mice were fed either a control or restricted diet, infected L. promastigotes, treated meglumine antimoniate, standard drug treating leishmaniasis. The effects evaluated through limiting dilution analysis (LDA). Compared mice, presented lower parasitic load spleen, which correlated spleen atrophy, refeeding process partially reversed but did not fully rescue Both groups high liver. Marasmic appeared impair efficacy treatment; however, exhibited robust decrease parasite load, was comparable group subjected treatment. Our data suggested marasmic affects establishment infection, addition reducing Furthermore, intervention used reverse observed effects. These findings highlight potential importance interventions clinical management populations.

Language: Английский

Citations

0
Construction and Evaluation of a Novel Nomogram for Predicting Dual Dimensional Frailty in Older Maintenance Haemodialysis Patients DOI
Xu‐Hua Zhou, Ying Zhu, Lin Chen

et al.

Journal of Clinical Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Objective To construct and evaluate a novel nomogram for predicting the risk of dual dimensional frailty (comorbidity between physical social frailty) in older maintenance haemodialysis. Methods A cross‐sectional investigation was conducted. total 386 MHD patients were recruited September December 2024 from four haemodialysis centres tertiary hospitals Sichuan Province, China. LASSO regression binary logistic employed to determine predictors frailty. The prediction performance model evaluated by discrimination calibration. decision curve utilised estimate clinical utility. Internal validation with 1000 bootstrap samples conducted minimise overfitting. Results In overall sample (386 cases), 92 (23.8%) exhibited Five relevant predictors, including activity, self‐perceived health status, ADL impairment, malnutrition, self‐perceptions aging, identified constructing nomogram. indicated excellent discriminatory power calibration model, while demonstrated its remarkable Conclusions constructed this study holds promise aiding healthcare professionals identifying risks among on haemodialysis, potentially informing early targeted interventions. Relevance Clinical Practice This enables nurses efficiently stratify dual‐dimensional during routine assessments, facilitating identification high‐risk patients. Its visual output can guide tailored interventions, such as exercise programmes, nutritional support, counselling, optimising resource allocation. Patient or Public Contribution Data collected self‐reported conditions patients' information. Reporting Method STROBE checklist employed.

Language: Английский

Citations

0
The clinical outcomes and effectiveness of antiviral agents among underweight patients with COVID-19 DOI
Jheng‐Yan Wu, Mei‐Yuan Liu,

Mei-Chuan Lee

et al.

Expert Review of Anti-infective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Jan. 5, 2024

Objectives This study investigated the outcomes of underweight patients with COVID-19 and effectiveness antiviral agents in this population.

Language: Английский

Citations

3
Prevalence of anterior nares colonization of Palestinian diabetic patients with Staphylococcus aureus or methicillin-resistant Staphylococcus aureus DOI Creative Commons

Muna M Abbas,

Motasim Almasri,

Alaeddin Abu-Zant

et al.

Quality Assurance and Safety of Crops & Foods, Journal Year: 2023, Volume and Issue: 15(4)

Published: Oct. 5, 2023

Staphylococcus aureus (S. aureus) is an opportunistic pathogen that colonizes the anterior nares of about one-third human population. Anterior colonization with S. or methicillin-resistant (MRSA) allows these pathogens to colonize skin and other anatomical locations. Accordingly, may cause different types endogenous infections. To investigate prevalence nasal carriage MRSA among Palestinian diabetic patients, swabs were taken from 151 undergo invasive surgeries. Thirty-five patients (35.1% total patients) found be colonized aureus, which 14 (9.7% MRSA. These proportions higher than those described for general population (30% 1.3%, respectively) even in (25.9% 2%, respectively). In addition, proportion was countries. Meanwhile, 30 53 isolates (57% isolates) also multidrug-resistant. remarkably high.

Language: Английский

Citations

8