Elephant in the room: natural killer cells don’t forget HIV either DOI
Stéphanie Jost, R. Keith Reeves

Current Opinion in HIV and AIDS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Purpose of review Like elephants (and T cells), accumulating evidence suggest natural killer (NK) cells never forget. The description adaptive or memory NK cells, which can be induced by HIV/SIV infections and vaccines associated with protective effects in persons HIV (PWH), has dramatically increased the interest leveraging to prevent infection suppress reservoirs. However, harnessing their full antiviral potential been hindered an incomplete understanding mechanisms underlying cell development infected recognition. Herein, we outline main discoveries around functions a focus on involvement infection. Recent findings diverse capabilities, including antigen-specific memory, cytokine-induced CMV-driven subsets, likely all play role Importantly, true have identified that mediate recall responses against multiple infectious agents such as HIV, influenza, SARS-CoV-2. NKG2C receptor is pivotal for certain it marks population enhanced antibody-dependent described mediating via recognition viral peptides presented HLA-E. Summary Antiviral adaptive/memory tremendous, but yet, untapped harnessed vaccine design, curative, other therapeutic interventions HIV.

Language: Английский

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells DOI Creative Commons

Jingjing Cong

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 28, 2020

Natural killer (NK) cells are the host's first line of defense against tumors and viral infections without prior sensitization. It is increasingly accepted that NK belong to innate lymphoid cell (ILC) family. Other ILCs, comprising ILC1s, ILC2s, ILC3s tissue inducer (LTi) cells, largely non-cytotoxic, tissue-resident which function protect local microenvironments insults maintain homeostasis. Recently, evidence has accumulated metabolism supports many aspects biology other metabolic reprogramming regulates their development function. Here, we outline current understanding ILC metabolism, describe how processes affected, defects coupled dysfunction in disease settings. Furthermore, summarize potential directions for immunotherapy involving targeting metabolism. Finally, discuss open questions rapidly expanding field

Language: Английский

Citations

52
Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes DOI Creative Commons
Andrew Hudson, Peng Wu, Kyle Kroll

et al.

Journal of Virology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Persons living with HIV experience significant metabolic dysregulation, frequently resulting in immune and other cellular dysfunction. However, our understanding of metabolism its relationship to immunity the context remains incompletely understood, especially as it relates acute early chronic phases infection. Herein, we employed mass spectrometry a simian immunodeficiency virus (SIV)-infected rhesus macaque model characterize changes over 500 plasma metabolites throughout SIV This broad metabolomic approach recapitulated known pathogenic signatures HIV, such perturbed tryptophan/kynurenine ratio, but also identified novel changes. We observed general decrease amino acid concentrations, notable exceptions elevated aspartate glutamate. Acute infection was marked by transient increase lactate dehydrogenase activity, indicating shift toward anaerobic metabolism. Indoleamine 2,3-dioxygenase defined kynurenine/tryptophan significantly increased both strongly correlated viral load. These results provide comprehensive characterization fluctuations during lentiviral infection, furthering crucial interplay between response. Our findings highlight systemic consequences potential targets for therapeutic intervention or biomarkers disease progression. IMPORTANCE Despite advances antiretroviral therapy pre-exposure prophylaxis, global challenge. Understanding underlying mechanisms is critical improving control development. Cellular represents yet underappreciated area system function. Metabolite availability pathway preferences directly influence functional response capacity cells are highly dysregulated To further impacts utilized cutting-edge spectrometry-based metabolome interrogation measure using an macaques. analysis provides insights into dynamic landscape revealing signatures. enhance complex infections, potentially informing new strategies detection, prevention, treatment HIV.

Language: Английский

Citations

0
Immuno-cell metabolic changes in HIV-1 infection DOI Creative Commons
Xu Li, Yue Jiang, Xuexing Zheng

et al.

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Recent research has shown that metabolic processes within immune cells are essential for both human immunodeficiency virus 1 (HIV-1) infection and the response. Throughout HIV-1 infection—from acute stages to chronic viral latency—immune experience shifts in energy demands pathways, paralleling T-cell exhaustion. Dysregulated metabolism compromises cell function, leading dysfunction persistent inflammation. Therefore, alterations constitute a critical mechanism progression This review specifically explores profiles roles of T cells, monocytes-macrophages, dendritic natural killer B at different infection, emphasizing effects on pathways diverse types. These insights offer valuable therapeutic strategies aimed inhibiting replication, restoring controlling disease progression.

Language: Английский

Citations

0
Delivery of NK cells in an injectable dynamic hydrogel effectively remodels tumor microenvironment and inhibits post-surgery tumor recurrence DOI
Jiaying Long, Yicong Zhang,

Mengxing Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163507 - 163507

Published: May 1, 2025

Language: Английский

Citations

0
Powering immunity: mitochondrial dynamics in natural killer cells DOI

Tias Verhezen,

An Wouters, Evelien Smits

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1 DOI Creative Commons
Ildefonso Sánchez‐Cerrillo,

María Agudo-Lera,

Olga Popova

et al.

EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Abstract Natural Killer (NK) cells are promising candidates for targeting persistently infected CD4 + T in people with HIV-1 (PWH). However, chronicity of infection impairs NK cell functionality, requiring additional strategies to potentiate their cytotoxic activity. This study demonstrates that dendritic primed nanoparticles containing Poly I:C (Nano-PIC-MDDC) enhance the natural function from effective responder PWH. These exhibit increased proportions NKG2C+ subsets capable eliminating through TRAIL receptor. In contrast, non-responder PWH, elevated expression inhibitory receptor TIGIT is associated reduced frequencies NKG2C and diminished expression. blockade restores cytotoxicity PWH against HIV-1-infected by upregulating TRAIL. Furthermore, combining Nano-PIC-MDDC-primed anti-TIGIT immunotherapy humanized NSG mice reduces expansion cells, preserves precursors increases tissue. Collectively, these findings support combined use Nano-PIC-MDDC as a immunotherapeutic strategy toward an cure.

Language: Английский

Citations

0
The Role of Natural Killer Cells and Their Metabolism in HIV-1 Infection DOI Creative Commons

Kewreshini K. Naidoo,

Marcus Altfeld

Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1584 - 1584

Published: Oct. 9, 2024

Natural killer (NK) cells are multifaceted innate effector that critically influence antiviral immunity, and several protective NK cell features modulate HIV-1 acquisition viral control have been described. Chronic infection leads to impairment has associated with metabolic dysregulations. Therapeutic approaches targeting cellular immune metabolism represent potential novel interventions reverse defective function in people living HIV.

Language: Английский

Citations

1
Immune dysregulation of decidual NK cells mediated by GRIM19 downregulation contributes to the occurrence of recurrent pregnancy loss DOI
Ying Wang,

An-Liang Guo,

Lin Yang

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

Citations

0
Elephant in the room: natural killer cells don’t forget HIV either DOI
Stéphanie Jost, R. Keith Reeves

Current Opinion in HIV and AIDS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Purpose of review Like elephants (and T cells), accumulating evidence suggest natural killer (NK) cells never forget. The description adaptive or memory NK cells, which can be induced by HIV/SIV infections and vaccines associated with protective effects in persons HIV (PWH), has dramatically increased the interest leveraging to prevent infection suppress reservoirs. However, harnessing their full antiviral potential been hindered an incomplete understanding mechanisms underlying cell development infected recognition. Herein, we outline main discoveries around functions a focus on involvement infection. Recent findings diverse capabilities, including antigen-specific memory, cytokine-induced CMV-driven subsets, likely all play role Importantly, true have identified that mediate recall responses against multiple infectious agents such as HIV, influenza, SARS-CoV-2. NKG2C receptor is pivotal for certain it marks population enhanced antibody-dependent described mediating via recognition viral peptides presented HLA-E. Summary Antiviral adaptive/memory tremendous, but yet, untapped harnessed vaccine design, curative, other therapeutic interventions HIV.

Language: Английский

Citations

0