Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells
Jingjing Cong
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Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: Aug. 28, 2020
Natural
killer
(NK)
cells
are
the
host's
first
line
of
defense
against
tumors
and
viral
infections
without
prior
sensitization.
It
is
increasingly
accepted
that
NK
belong
to
innate
lymphoid
cell
(ILC)
family.
Other
ILCs,
comprising
ILC1s,
ILC2s,
ILC3s
tissue
inducer
(LTi)
cells,
largely
non-cytotoxic,
tissue-resident
which
function
protect
local
microenvironments
insults
maintain
homeostasis.
Recently,
evidence
has
accumulated
metabolism
supports
many
aspects
biology
other
metabolic
reprogramming
regulates
their
development
function.
Here,
we
outline
current
understanding
ILC
metabolism,
describe
how
processes
affected,
defects
coupled
dysfunction
in
disease
settings.
Furthermore,
summarize
potential
directions
for
immunotherapy
involving
targeting
metabolism.
Finally,
discuss
open
questions
rapidly
expanding
field
Language: Английский
Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes
Journal of Virology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
ABSTRACT
Persons
living
with
HIV
experience
significant
metabolic
dysregulation,
frequently
resulting
in
immune
and
other
cellular
dysfunction.
However,
our
understanding
of
metabolism
its
relationship
to
immunity
the
context
remains
incompletely
understood,
especially
as
it
relates
acute
early
chronic
phases
infection.
Herein,
we
employed
mass
spectrometry
a
simian
immunodeficiency
virus
(SIV)-infected
rhesus
macaque
model
characterize
changes
over
500
plasma
metabolites
throughout
SIV
This
broad
metabolomic
approach
recapitulated
known
pathogenic
signatures
HIV,
such
perturbed
tryptophan/kynurenine
ratio,
but
also
identified
novel
changes.
We
observed
general
decrease
amino
acid
concentrations,
notable
exceptions
elevated
aspartate
glutamate.
Acute
infection
was
marked
by
transient
increase
lactate
dehydrogenase
activity,
indicating
shift
toward
anaerobic
metabolism.
Indoleamine
2,3-dioxygenase
defined
kynurenine/tryptophan
significantly
increased
both
strongly
correlated
viral
load.
These
results
provide
comprehensive
characterization
fluctuations
during
lentiviral
infection,
furthering
crucial
interplay
between
response.
Our
findings
highlight
systemic
consequences
potential
targets
for
therapeutic
intervention
or
biomarkers
disease
progression.
IMPORTANCE
Despite
advances
antiretroviral
therapy
pre-exposure
prophylaxis,
global
challenge.
Understanding
underlying
mechanisms
is
critical
improving
control
development.
Cellular
represents
yet
underappreciated
area
system
function.
Metabolite
availability
pathway
preferences
directly
influence
functional
response
capacity
cells
are
highly
dysregulated
To
further
impacts
utilized
cutting-edge
spectrometry-based
metabolome
interrogation
measure
using
an
macaques.
analysis
provides
insights
into
dynamic
landscape
revealing
signatures.
enhance
complex
infections,
potentially
informing
new
strategies
detection,
prevention,
treatment
HIV.
Language: Английский
Immuno-cell metabolic changes in HIV-1 infection
Infectious Diseases & Immunity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Abstract
Recent
research
has
shown
that
metabolic
processes
within
immune
cells
are
essential
for
both
human
immunodeficiency
virus
1
(HIV-1)
infection
and
the
response.
Throughout
HIV-1
infection—from
acute
stages
to
chronic
viral
latency—immune
experience
shifts
in
energy
demands
pathways,
paralleling
T-cell
exhaustion.
Dysregulated
metabolism
compromises
cell
function,
leading
dysfunction
persistent
inflammation.
Therefore,
alterations
constitute
a
critical
mechanism
progression
This
review
specifically
explores
profiles
roles
of
T
cells,
monocytes-macrophages,
dendritic
natural
killer
B
at
different
infection,
emphasizing
effects
on
pathways
diverse
types.
These
insights
offer
valuable
therapeutic
strategies
aimed
inhibiting
replication,
restoring
controlling
disease
progression.
Language: Английский
Delivery of NK cells in an injectable dynamic hydrogel effectively remodels tumor microenvironment and inhibits post-surgery tumor recurrence
Jiaying Long,
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Yicong Zhang,
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Mengxing Zhang
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et al.
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 163507 - 163507
Published: May 1, 2025
Language: Английский
Powering immunity: mitochondrial dynamics in natural killer cells
Tias Verhezen,
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An Wouters,
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Evelien Smits
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et al.
Trends in Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Language: Английский
Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1
EMBO Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 5, 2025
Abstract
Natural
Killer
(NK)
cells
are
promising
candidates
for
targeting
persistently
infected
CD4
+
T
in
people
with
HIV-1
(PWH).
However,
chronicity
of
infection
impairs
NK
cell
functionality,
requiring
additional
strategies
to
potentiate
their
cytotoxic
activity.
This
study
demonstrates
that
dendritic
primed
nanoparticles
containing
Poly
I:C
(Nano-PIC-MDDC)
enhance
the
natural
function
from
effective
responder
PWH.
These
exhibit
increased
proportions
NKG2C+
subsets
capable
eliminating
through
TRAIL
receptor.
In
contrast,
non-responder
PWH,
elevated
expression
inhibitory
receptor
TIGIT
is
associated
reduced
frequencies
NKG2C
and
diminished
expression.
blockade
restores
cytotoxicity
PWH
against
HIV-1-infected
by
upregulating
TRAIL.
Furthermore,
combining
Nano-PIC-MDDC-primed
anti-TIGIT
immunotherapy
humanized
NSG
mice
reduces
expansion
cells,
preserves
precursors
increases
tissue.
Collectively,
these
findings
support
combined
use
Nano-PIC-MDDC
as
a
immunotherapeutic
strategy
toward
an
cure.
Language: Английский
The Role of Natural Killer Cells and Their Metabolism in HIV-1 Infection
Kewreshini K. Naidoo,
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Marcus Altfeld
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Viruses,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1584 - 1584
Published: Oct. 9, 2024
Natural
killer
(NK)
cells
are
multifaceted
innate
effector
that
critically
influence
antiviral
immunity,
and
several
protective
NK
cell
features
modulate
HIV-1
acquisition
viral
control
have
been
described.
Chronic
infection
leads
to
impairment
has
associated
with
metabolic
dysregulations.
Therapeutic
approaches
targeting
cellular
immune
metabolism
represent
potential
novel
interventions
reverse
defective
function
in
people
living
HIV.
Language: Английский
Immune dysregulation of decidual NK cells mediated by GRIM19 downregulation contributes to the occurrence of recurrent pregnancy loss
Ying Wang,
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An-Liang Guo,
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Lin Yang
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et al.
Molecular and Cellular Biochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Language: Английский
Elephant in the room: natural killer cells don’t forget HIV either
Current Opinion in HIV and AIDS,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Purpose
of
review
Like
elephants
(and
T
cells),
accumulating
evidence
suggest
natural
killer
(NK)
cells
never
forget.
The
description
adaptive
or
memory
NK
cells,
which
can
be
induced
by
HIV/SIV
infections
and
vaccines
associated
with
protective
effects
in
persons
HIV
(PWH),
has
dramatically
increased
the
interest
leveraging
to
prevent
infection
suppress
reservoirs.
However,
harnessing
their
full
antiviral
potential
been
hindered
an
incomplete
understanding
mechanisms
underlying
cell
development
infected
recognition.
Herein,
we
outline
main
discoveries
around
functions
a
focus
on
involvement
infection.
Recent
findings
diverse
capabilities,
including
antigen-specific
memory,
cytokine-induced
CMV-driven
subsets,
likely
all
play
role
Importantly,
true
have
identified
that
mediate
recall
responses
against
multiple
infectious
agents
such
as
HIV,
influenza,
SARS-CoV-2.
NKG2C
receptor
is
pivotal
for
certain
it
marks
population
enhanced
antibody-dependent
described
mediating
via
recognition
viral
peptides
presented
HLA-E.
Summary
Antiviral
adaptive/memory
tremendous,
but
yet,
untapped
harnessed
vaccine
design,
curative,
other
therapeutic
interventions
HIV.
Language: Английский