Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma Photoimmunotherapy DOI

Gaowei Li,

Shichao Jiang, Zongliang Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Glioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options. Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success hindered by inadequate T cell infiltration and activation due to the acidic immunosuppressive microenvironment. Photothermal immunotherapy lyses tumors activates immune responses, complementing BiTEs. This study innovatively employs donor engineering strategy develop hemicyanine dyes (Hcys) that emit from near‐infrared (NIR) I NIR II. The Hcy excellent properties encapsulated in an amphiphilic micelle, forming nano assembly lactate oxidase (PLH1100). PLH1100 exhibits spectral absorption at 980 nm, photothermal conversion efficiency of 58.7%, capability NIR‐II imaging. Besides ablation, regulates lactic acid metabolism immunogenic death, improving microenvironment promoting activation. Further studies demonstrate effectively kills human murine cells, inhibits orthotopic U87 growth BALB/c‐nu mice, enhances efficacy Fn14‐targeted BiTE GL261 C57BL/6 achieving synergistic “1+1>2” therapeutic effect. Collectively, this work opens new pathway using Hcy‐based molecules combined drugs therapy, significant clinical potential.

Language: Английский

The role of the complement system in the response to cytotoxic therapy DOI Creative Commons

K Lee,

Qingyang Zhang, Tatsuya Suwa

et al.

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 77, P. 101927 - 101927

Published: Jan. 6, 2025

The complement system is increasingly recognised as a key player in tumour progression and response to cancer treatment. Cytotoxic therapies, including chemo- radiotherapy are standard-of-care for the majority of patients. Cytotoxics have been found alter expression proteins activation components. Many recent reports highlight role local dysregulation microenvironment how targeting such can either anti- or pro-tumoricidal effects depending on several factors treatment scheduling, type its characteristics. This review will explore complex cytotoxic therapy regulation what lessons be learnt identify most effective way therapeutically modulate therapy.

Language: Английский

Citations

2
Cutting-Edge Technologies Illuminate the Neural Landscape of Cancer: Insights into Tumor Development DOI
Yajing Wang, Zhao‐Jun Wang,

Xinyuan Mao

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217667 - 217667

Published: March 1, 2025

Language: Английский

Citations

0
Complement and the hallmarks of cancer DOI Creative Commons
Mikel Rezola Artero,

Andrea Minery,

Leon Nedelcev

et al.

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101950 - 101950

Published: April 4, 2025

The hallmarks of cancer are a set traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, innate immune complement system plays critical role. It can operate canonically-in blood and tissues-via phagocytosis, inflammation, complement-dependent cytotoxicity, similar to its roles against invading pathogens. Additionally, it functions non-canonically by modulating behavior within tumor microenvironment intracellular landscape which regulates cell fate. These mechanisms contribute complex context-dependent in both growth antitumor immunity, shaped characteristics dynamic microenvironment. This review analyses multifaceted interplay between proteins positioning this as target therapy.

Language: Английский

Citations

0
Interplay between the complement system and other immune pathways in the tumor microenvironment DOI Creative Commons
Cecília Garlanda, Monica Dambra, Elena Magrini

et al.

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101951 - 101951

Published: April 9, 2025

Language: Английский

Citations

0
Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma Photoimmunotherapy DOI

Gaowei Li,

Shichao Jiang, Zongliang Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Glioblastoma (GBM) is a highly malignant intracranial tumor with limited treatment options. Bispecific T‐cell engagers (BiTEs) are being explored for GBM treatment, but their success hindered by inadequate T cell infiltration and activation due to the acidic immunosuppressive microenvironment. Photothermal immunotherapy lyses tumors activates immune responses, complementing BiTEs. This study innovatively employs donor engineering strategy develop hemicyanine dyes (Hcys) that emit from near‐infrared (NIR) I NIR II. The Hcy excellent properties encapsulated in an amphiphilic micelle, forming nano assembly lactate oxidase (PLH1100). PLH1100 exhibits spectral absorption at 980 nm, photothermal conversion efficiency of 58.7%, capability NIR‐II imaging. Besides ablation, regulates lactic acid metabolism immunogenic death, improving microenvironment promoting activation. Further studies demonstrate effectively kills human murine cells, inhibits orthotopic U87 growth BALB/c‐nu mice, enhances efficacy Fn14‐targeted BiTE GL261 C57BL/6 achieving synergistic “1+1>2” therapeutic effect. Collectively, this work opens new pathway using Hcy‐based molecules combined drugs therapy, significant clinical potential.

Language: Английский

Citations

2