Circadian gating: concepts, processes, and opportunities DOI
Pirita Paajanen, Jacqueline M. Kimmey, Antony N. Dodd

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Circadian clocks provide a biological measure of time that coordinates metabolism, physiology and behaviour with 24 h cycles in the environment. systems have variety characteristic properties, such as entrainment to environmental cues, self-sustaining rhythm about temperature compensation circadian rhythm. In this perspective, we discuss process gating, which refers restriction event particular times day by clock. We introduce principles processes associated gating organisms, including some mechanisms. highlight socioeconomic opportunities presented investigation using selected examples from medicine agricultural crop production illustrate its importance. This article is part Theo Murphy meeting issue ‘Circadian rhythms infection immunity’.

Language: Английский

Circadian rhythms and disorders of the timing of sleep DOI
Nicholas Meyer, Allison G. Harvey, Steven W. Lockley

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

Citations

172
Dendritic cells direct circadian anti-tumour immune responses DOI Creative Commons
Chen Wang, Coline Barnoud, Mara Cenerenti

et al.

Nature, Journal Year: 2022, Volume and Issue: 614(7946), P. 136 - 143

Published: Dec. 5, 2022

Abstract The process of cancer immunosurveillance is a mechanism tumour suppression that can protect the host from development throughout its lifetime 1,2 . However, it unknown whether effectiveness fluctuates over single day. Here we demonstrate initial time day engraftment dictates ensuing size across mouse models. Using immunodeficient mice as well lacking lineage-specific circadian functions, show dendritic cells (DCs) and CD8 + T exert anti-tumour functions control melanoma volume. Specifically, find rhythmic trafficking DCs to draining lymph node governs response tumour-antigen-specific dependent on expression co-stimulatory molecule CD80. As consequence, immunotherapy more effective when synchronized with DC shows outcomes in suggests similar effects humans. These data rhythms immune components are not only critical for controlling but also be therapeutic relevance.

Language: Английский

Citations

132
The circadian immune system DOI
Chen Wang, Lydia K. Lutes, Coline Barnoud

et al.

Science Immunology, Journal Year: 2022, Volume and Issue: 7(72)

Published: June 3, 2022

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were first to identify responses be under a circadian control. Only last decade, however, have molecular factors governing rhythms been identified. These revealed complex picture of interconnectivity rhythmicity within cells with that their environment. Here, we provide global overview system, focusing on recent advances rapidly expanding field immunology.

Language: Английский

Citations

122
Trained immunity: adaptation within innate immune mechanisms DOI
Jorge Domínguez‐Andrés, Jéssica Cristina dos Santos, Siroon Bekkering

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 313 - 346

Published: Aug. 18, 2022

The mechanisms underlying innate immune memory have been extensively explored in the last decades but are fact largely unknown. Although specificity of adaptive vertebrates is ensured through recombination immunoglobulin family genes and clonal expansion, basic cells’ nonspecific increased responsiveness rely on epigenetic, transcriptional, metabolic programs after transient stimulation. Changes these result enhanced to secondary challenges with a wide variety stimuli. This phenomenon termed “trained immunity” or “innate memory.” On one hand, trained immunity improves response infections vaccination, facilitating stronger responses protection against microbial Conversely, may contribute pathophysiology cardiovascular, autoinflammatory, neurodegenerative diseases. In this review, we gather current body knowledge field summarize foundations immunity, different cell types involved, its consequences for health disease, potential modulation as therapeutic tool.

Language: Английский

Citations

92
Effect of immunotherapy-infusion time of day on survival of patients with advanced cancers: a study-level meta-analysis DOI Creative Commons
Thierry Landre, Abdoulaye Karaboué, Zachary S. Buchwald

et al.

ESMO Open, Journal Year: 2024, Volume and Issue: 9(2), P. 102220 - 102220

Published: Jan. 21, 2024

Background

Immune checkpoint inhibitors (ICIs) have become the standard of care for numerous malignancies. Emerging evidence suggests that time day (ToD) ICI administration could impact outcomes patients with cancer. The consistency ToD effects on efficacy awaits initial evaluation.

Materials and methods

This meta-analysis integrates progression-free survival (PFS) overall (OS) data from studies a defined ‘cut-off' ToD. Hazard ratios (HRs) [95% confidence interval (CI)] an earlier progression or death according to ‘early' ‘late' ICIs were collected each report pooled.

Results

Thirteen involved 1663 (Eastern Cooperative Oncology Group performance status 0-1, 83%; males/females, 67%/33%) non-small-cell lung cancer (47%), renal cell carcinoma (24%), melanoma (20%), urothelial (5%), esophageal (4%). Most received anti-programmed protein 1 death-ligand (98%), small proportion also anti-cytotoxic T-lymphocyte-associated 4 (anti-CTLA-4) (18%). cut-offs 13:00 14:00 (i.e. median infusion time), six studies, 16:00 16:30 reported threshold weaker vaccination responses) seven studies. Pooled analyses revealed early groups had longer OS (HR 0.50, 95% CI 0.42-0.58; P < 0.00001) PFS 0.51, 0.42-0.61; compared late groups.

Conclusions

Patients selected metastatic cancers seemed largely benefit infusions, which is consistent circadian mechanisms in immune-cell functions trafficking. Prospective randomized trials are needed establish recommendations optimal timing ICI-based therapies.

Language: Английский

Citations

25
Circadian Rhythms, Disease and Chronotherapy DOI
Yool Lee, Jeffrey Field, Amita Sehgal

et al.

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 36(6), P. 503 - 531

Published: Sept. 22, 2021

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating

Language: Английский

Citations

90
Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort DOI Creative Commons
Cathy Wyse, Grace O’Malley, Andrew N. Coogan

et al.

iScience, Journal Year: 2021, Volume and Issue: 24(4), P. 102255 - 102255

Published: March 1, 2021

Seasonal disease outbreaks are perennial features of human infectious but the factors generating these patterns unclear. Here we investigate seasonal and daytime variability in multiple immune parameters 329,261 participants UK Biobank test for associations with a wide range environmental lifestyle factors, including changes day length, outdoor temperature vitamin D at time blood sample was collected. were evident lymphocyte neutrophil counts, C-reactive protein CRP, not monocytes, independent lifestyle, demographic, factors. All assessed demonstrated significant variation that confounding At population level, vary across season day, Both fundamental dimensions function should be considered all studies immuno-prophylaxis transmission.

Language: Английский

Citations

78
Time of day influences immune response to an inactivated vaccine against SARS-CoV-2 DOI Creative Commons
Hui Zhang, Yihao Liu,

Dayue Liu

et al.

Cell Research, Journal Year: 2021, Volume and Issue: 31(11), P. 1215 - 1217

Published: Aug. 2, 2021

Language: Английский

Citations

76
Time-Dependent Efficacy of Checkpoint Inhibitor Nivolumab: Results from a Pilot Study in Patients with Metastatic Non-Small-Cell Lung Cancer DOI Open Access
Abdoulaye Karaboué,

T. Collon,

Ida Pavese

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 896 - 896

Published: Feb. 11, 2022

Prior experimental and human studies have demonstrated the circadian organization of immune cells' proliferation, trafficking, antigen recognition destruction. Nivolumab targets T(CD8) cells, functions, trafficking which are regulated by clocks, hence suggesting possible daily changes in nivolumab's efficacy. Worse progression-free survival (PFS), overall (OS) were reported for malignant melanoma patients receiving more than 20% their checkpoint inhibitor infusions after 16:30 as compared to earlier day.Consecutive metastatic non-small-cell cancer (NSCLC) received nivolumab (240 mg iv q 2 weeks) at a time that was 'randomly' allocated each course on logistical basis day-hospital coordinators. The median all administrations computed patient. study population split into two timing groups based upon value treatment times patients. CTCAE-toxicity rates, iRECIST-tumor responses, PFS OS according timing. curves hazard ratios (HR) major categories characteristics. Multivariable sensitivity analyses also performed.The accrued 95 stage-IV NSCLC (PS 0-1, 96%), aged 41-83 years. majority occurred between 9:27 12:54 48 ('morning' group) 12:55 17:14 other 47 ('afternoon' group). Median (95% CL) 11.3 months (5.5-17.1) 'morning' group 3.1 (1.5-4.6) 'afternoon' one (p < 0.001). 34.2 (15.1-53.3) 9.6 (4.9-14.4) one, respectively identified significant predictor longer OS, with respective HR values 0.26 (0.11-0.58) 0.17 (0.08-0.37). effect consistent across patient subgroups tested.Nivolumab nearly four effective following dosing this cohort Prospective timing-studies needed minimize risk resistance maximize benefits from inhibitors.

Language: Английский

Citations

64
Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study DOI
David C. Qian, T. Kleber, Brianna Brammer

et al.

The Lancet Oncology, Journal Year: 2021, Volume and Issue: 22(12), P. 1777 - 1786

Published: Nov. 12, 2021

Language: Английский

Citations

64