JCO Precision Oncology,
Journal Year:
2025,
Volume and Issue:
9
Published: Jan. 1, 2025
PURPOSE
Chronoradiobiology
has
emerged
as
a
potential
field
of
study
with
therapeutic
implications
for
cancer
treatment.
We
aimed
to
investigate
the
association
between
radiation
chronotherapy
and
efficacy
toxicity
patients
nasopharyngeal
carcinoma
(NPC).
PATIENTS
AND
METHODS
Patients
nonmetastatic
NPC
treated
intensity-modulated
radiotherapy
in
Fujian
Cancer
Hospital
January
2017
December
2019
were
included.
Propensity
score
matching
(PSM)
1:1:1
was
used
account
selection
bias.
Cox
regression
analysis
performed
explore
impact
timing
on
patient
survival.
Sensitivity
implemented
determine
size
directional
stability.
RESULTS
One
thousand
forty
met
inclusion
criteria
332
included
PSM
cohort.
In
unmatched
cohort
analysis,
morning
exhibited
significantly
superior
overall
survival
(OS)
outcome
(hazard
ratio
[HR],
0.60
[95%
CI,
0.40
0.91],
adjusted
log-rank
P
=
.028)
than
afternoon
one.
After
it
observed
that
individuals
undergoing
group
(HR,
5.88
2.55
13.58],
.004)
night
4.81
1.91
12.11],
.018)
displayed
tendency
toward
shorter
OS
compared
group.
No
significant
differences
acute
treatment-related
adverse
effects
among
three
groups.
Morning
demonstrated
consistent
robustness
multivariable
thereby
establishing
an
higher
OS.
The
directionality
effect
across
sensitivity
analysis.
CONCLUSION
These
results
underscore
benefits
scheduling
management,
although
prospective
studies
are
needed
confirm
these
findings.
Cell,
Journal Year:
2024,
Volume and Issue:
187(11), P. 2690 - 2702.e17
Published: May 1, 2024
The
quality
and
quantity
of
tumor-infiltrating
lymphocytes,
particularly
CD8+
T
cells,
are
important
parameters
for
the
control
tumor
growth
response
to
immunotherapy.
Here,
we
show
in
murine
human
cancers
that
these
exhibit
circadian
oscillations,
driven
by
both
endogenous
clock
leukocytes
rhythmic
leukocyte
infiltration,
which
depends
on
endothelial
cells
microenvironment.
To
harness
rhythms
therapeutically,
demonstrate
efficacy
chimeric
antigen
receptor
cell
therapy
immune
checkpoint
blockade
can
be
improved
adjusting
time
treatment
during
day.
Furthermore,
time-of-day-dependent
signatures
models
predict
overall
survival
patients
with
melanoma
correlate
anti-PD-1
therapy.
Our
data
functional
significance
dynamics
microenvironment
suggest
importance
leveraging
features
improving
future
clinical
trial
design
patient
care.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2023,
Volume and Issue:
18(1), P. 439 - 466
Published: Jan. 24, 2023
Hepatocytes
are
the
main
workers
in
hepatic
factory,
managing
metabolism
of
nutrients
and
xenobiotics,
production
recycling
proteins,
glucose
lipid
homeostasis.
Division
labor
between
hepatocytes
is
critical
to
coordinate
complex
complementary
or
opposing
multistep
processes,
similar
distributed
tasks
at
an
assembly
line.
This
so-called
metabolic
zonation
has
both
spatial
temporal
components.
Spatial
distribution
function
different
lobular
zones
necessary
perform
sequential
processes
assign
right
environment.
Moreover,
control
align
required
feeding
fasting
cycles.
Disruption
this
spatiotemporal
organization
impairs
key
with
local
systemic
consequences.
Many
diseases,
such
as
nonalcoholic
steatohepatitis
diabetes,
associated
impaired
liver
zonation.
Recent
technological
advances
shed
new
light
on
gene
expression
networks
controlling
how
their
deregulation
may
be
involved
a
large
variety
diseases.
We
summarize
current
knowledge
about
consequences
pathobiology.
ESMO Open,
Journal Year:
2024,
Volume and Issue:
9(2), P. 102220 - 102220
Published: Jan. 21, 2024
Background
Immune
checkpoint
inhibitors
(ICIs)
have
become
the
standard
of
care
for
numerous
malignancies.
Emerging
evidence
suggests
that
time
day
(ToD)
ICI
administration
could
impact
outcomes
patients
with
cancer.
The
consistency
ToD
effects
on
efficacy
awaits
initial
evaluation.
Materials
and
methods
This
meta-analysis
integrates
progression-free
survival
(PFS)
overall
(OS)
data
from
studies
a
defined
‘cut-off'
ToD.
Hazard
ratios
(HRs)
[95%
confidence
interval
(CI)]
an
earlier
progression
or
death
according
to
‘early'
‘late'
ICIs
were
collected
each
report
pooled.
Results
Thirteen
involved
1663
(Eastern
Cooperative
Oncology
Group
performance
status
0-1,
83%;
males/females,
67%/33%)
non-small-cell
lung
cancer
(47%),
renal
cell
carcinoma
(24%),
melanoma
(20%),
urothelial
(5%),
esophageal
(4%).
Most
received
anti-programmed
protein
1
death-ligand
(98%),
small
proportion
also
anti-cytotoxic
T-lymphocyte-associated
4
(anti-CTLA-4)
(18%).
cut-offs
13:00
14:00
(i.e.
median
infusion
time),
six
studies,
16:00
16:30
reported
threshold
weaker
vaccination
responses)
seven
studies.
Pooled
analyses
revealed
early
groups
had
longer
OS
(HR
0.50,
95%
CI
0.42-0.58;
P
<
0.00001)
PFS
0.51,
0.42-0.61;
compared
late
groups.
Conclusions
Patients
selected
metastatic
cancers
seemed
largely
benefit
infusions,
which
is
consistent
circadian
mechanisms
in
immune-cell
functions
trafficking.
Prospective
randomized
trials
are
needed
establish
recommendations
optimal
timing
ICI-based
therapies.
Journal of Sleep Research,
Journal Year:
2022,
Volume and Issue:
31(4)
Published: June 7, 2022
Summary
The
field
of
“circadian
medicine”
is
a
recent
addition
to
chronobiology
and
sleep
research
efforts.
It
represents
logical
step
arising
from
the
increasing
insights
into
circadian
system
its
interactions
with
life
in
urbanised
societies;
applying
these
health/disease
balance
at
home
medical
practice
(outpatient)
clinic
(inpatient).
Despite
fast
expansion
proliferating
efforts,
medicine
lacks
formal
framework
categorise
many
observations
describing
among
system,
sleep,
balance.
A
good
allows
us
then
assign
them
one
or
more
components
hypothesised
interactions.
Such
assignments
can
lead
experiments
that
document
causal
(rather
than
correlational)
relationships
move
discovering
mechanisms.
This
review
details
such
proposed
for
will
hopefully
trigger
discussion
our
colleagues,
so
be
improved
expanded.
As
basis
medicine,
we
define
health”
how
it
links
general
health.
We
put
context
literature
examples
six
domains
balance:
fertility,
cancer,
immune
mental
health,
cardiovascular,
metabolism.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(20), P. 5071 - 5071
Published: Oct. 17, 2022
Living
organisms
present
rhythmic
fluctuations
every
24
h
in
their
behavior
and
metabolism
to
anticipate
changes
the
environment.
These
are
controlled
by
a
very
complex
molecular
mechanism,
circadian
clock,
that
regulates
expression
of
multiple
genes
ensure
right
functioning
body.
An
individual’s
system
is
altered
during
aging,
this
related
numerous
age-associated
pathologies
other
alterations
could
contribute
development
cancer.
Nowadays,
there
an
increasing
interest
understanding
how
rhythms
be
used
treatment
Chronotherapy
aims
understand
impact
biological
have
on
response
therapy
optimize
its
action,
maximize
health
benefits
minimize
possible
adverse
effects.
Clinical
trials
so
far
confirmed
optimal
timing
with
chemo
or
immunotherapies
decrease
drug
toxicity
increase
efficacy.
Instead,
chronoradiotherapy
seems
treatment-related
symptoms
rather
than
tumor
progression
patient
survival.
In
addition,
potential
therapeutic
targets
within
clock
also
been
identified.
Therefore,
results
application
chronotherapy
cancer
until
now
challenging,
feasible,
applied
clinical
practice
improve
without
additional
costs.
However,
different
limitations
variables
such
as
age,
sex,
chronotypes,
among
others,
should
overcome
before
can
really
put
into
practice.
The Annual Review of Pharmacology and Toxicology,
Journal Year:
2023,
Volume and Issue:
64(1), P. 89 - 114
Published: Sept. 19, 2023
Today's
challenge
for
precision
medicine
involves
the
integration
of
impact
molecular
clocks
on
drug
pharmacokinetics,
toxicity,
and
efficacy
toward
personalized
chronotherapy.
Meaningful
improvements
tolerability
and/or
medications
through
proper
administration
timing
have
been
confirmed
over
past
decade
immunotherapy
chemotherapy
against
cancer,
as
well
commonly
used
pharmacological
agents
in
cardiovascular,
metabolic,
inflammatory,
neurological
conditions.
Experimental
human
studies
recently
revealed
sexually
dimorphic
circadian
responses.
Dedicated
randomized
clinical
trials
should
now
aim
to
issue
recommendations
daily
medical
practice,
integrating
innovative
technologies
remote
longitudinal
monitoring
metrics,
statistical
prediction
clock
function
from
single-timepoint
biopsies,
multiscale
biorhythmic
mathematical
modelling.
Importantly,
chronofit
patients
with
a
robust
function,
who
would
benefit
most
chronotherapy,
need
be
identified.
Conversely,
nonchronofit
could
emerging
class
chronobiotics
targeting
clock.
