Meta-hallmarks of aging and cancer

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 12 - 35

Published: Jan. 1, 2023

Language: Английский

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Bacteria in cancer initiation, promotion and progression

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(9), P. 600 - 618

Published: July 3, 2023

Language: Английский

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The microbial landscape of colorectal cancer

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(4), P. 240 - 254

Published: Oct. 4, 2023

Language: Английский

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Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(21), P. 12072 - 12082

Published: May 16, 2024

polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially T cell-mediated antitumor immunity. In this study, we found that significantly inhibited growth and activated immunity colorectal cancer (CRC). spleens tissues, proportion cytotoxic CD8

Language: Английский

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A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study

Gastroenterology, Journal Year: 2023, Volume and Issue: 165(3), P. 582 - 599.e8

Published: May 30, 2023

Background & AimsFecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers noninvasive CRC diagnosis.MethodsA total of 1273 small RNA sequencing experiments were performed multiple biospecimens. a cross-sectional study, miRNA investigated fecal samples from an Italian and Czech cohort (155 CRCs, 87 adenomas, 96 other intestinal diseases, 141 colonoscopy-negative controls). A predictive signature detection was defined by machine learning strategy tested additional patients 80 healthy volunteers. compared with those 132 tumors/adenomas paired adjacent mucosa, 210 plasma extracellular vesicle samples, 185 immunochemical test leftover samples.ResultsTwenty-five miRNAs showed altered levels the both cohorts (adjusted P < .05). 5-miRNA signature, including miR-149-3p, miR-607-5p, miR-1246, miR-4488, miR-6777-5p, distinguished control individuals (area under curve [AUC], 0.86; 95% confidence interval [CI], 0.79–0.94) validated independent (AUC, 0.96; CI, 0.92–1.00). The classified low-/high-stage advanced adenomas 0.82; 0.71–0.97). Tissue mirrored different gastrointestinal diseases highlighted specifically dysregulated CRC. good correlation collected preservative buffer, their alterations could be detected adenoma patients.ConclusionsOur comprehensive miRNome analysis identified accurately discriminating aimed at improving diagnosis strategies. Fecal diagnosis. samples. Twenty-five patients. Our

Language: Английский

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Overview of microbial profiles in human hepatocellular carcinoma and adjacent nontumor tissues

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 2, 2023

Abstract Background Intratumoral microbial communities have been recently discovered to exist in a variety of cancers and found be intricately involved tumour progression. Therefore, investigating the profiles functions intratumoral distribution hepatocellular carcinoma (HCC) is imperative. Methods To verify presence microorganisms HCC, we performed fluorescence situ hybridization (FISH) using HCC tissues conducted MiSeq 99 paracancerous identify key changes metabolic pathways affecting progression through bioinformatics methods. Results Microbial diversity was significantly higher than adjacent tissues. The abundances such as Enterobacteriaceae , Fusobacterium Neisseria were increased tissues, while certain antitumour bacteria Pseudomonas decreased. Processes fatty acid lipid synthesis enhanced microbiota which may factor microbes influence There considerable differences their within tissue collected from patients with different clinical features. Conclusion We comprehensively evaluated atlas preliminarily explored mechanism effects community involving metabolism on progression, lays foundation for further research this field.

Language: Английский

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Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/β-catenin signaling pathway to counter the progression of colorectal cancer

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(14), P. 4393 - 4410

Published: Jan. 1, 2023

Akkermansia muciniphila (A. muciniphila), a gram-negative anaerobic bacterium, is selectively decreased in the fecal microbiota of patients with colorectal cancer (CRC), but its molecular mechanism CRC development remains inconclusive. In this study, we first confirmed inhibitory effect A. on formation and analyzed metabolic role intestinal flora human Polyps, A-CRA (advanced adenoma) samples. To better clarify development, pseudo-germ-free (GF) azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model was established, followed by infection or without muciniphila. Metabolomic analysis RNA-seq showed tryptophan-mediated aryl hydrocarbon receptor (AhR) significantly down-regulated muciniphila-infected mice. Then, mice specific AhR deficiency (AhRfl/fl Cre) were generated used 2 murine models: AOM/DSS treatment as carcinogen-induced colon genetically induced using ApcMin/+ Notably, inhibited growth model. Moreover, inhibited, rather than enhanced, tumor tumor-derived organoids Apc-deficient cells both vivo vitro activating Wnt/β-catenin signaling TCF4/LEF1-dependent transcription. Furthermore, antitumor effectiveness abolished either subcutaneous transplantation AhR-silenced cells, AhR-deficienty spontaneous conclusion, supplementation protected from specifically inhibiting AhR/β-catenin signaling.

Language: Английский

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Gut microbiota dysbiosis promotes the development of epithelial ovarian cancer via regulating Hedgehog signaling pathway

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 6, 2023

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, which remains a threat to female health at all ages. Hypotheses for EOC development include continuous presence of inflammation, in microbiota and inflammatory cytokines participate cancer-related signaling pathway activation. Hedgehog (Hh) prominent progression, interacts with inflammation response related gut (GM). However, precise roles GM during this process are unknown. Here, we showed that from patients differed healthy women had dysbiosis. We found modeling may lead changes mice, it restored after administration controls, while further exacerbated Furthermore, markedly promoted tumor progression activated Hh signaling; meanwhile, increased extent NF-κB signaling, but controls improved them. Our results demonstrate how dysbiosis by activating mediated TLR4/NF-κB signaling. anticipate our assay be new thought exploring role development. improving novel therapeutic approach delaying

Language: Английский

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Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 21, 2023

The crucial role of intratumoral bacteria in the progression cancer has been gradually recognized with development sequencing technology. Several which have identified as pathogens that induce progression, metastasis, and poor outcome cancer, while tumor vascular networks immunosuppressive microenvironment provide shelters for localization. Thus, mutually-beneficial interplay between tumors, named "pathogen-tumor symbionts", is probably a potential therapeutic site treatment. Herein, we proposed destroying pathogen-tumor symbionts strategy kills pathogens, F. nucleatum, to break symbiont synergize kill colorectal (CRC) cells. This was achieved by groundbreaking protein-supported copper single-atom nanozyme (BSA-Cu SAN) inspired structures native enzymes are based on protein, metal elements active center. BSA-Cu SAN can exert catalytic therapy generating reactive oxygen species (ROS) depleting GSH. vitro vivo experiments demonstrate passively targets sites efficiently scavenges nucleatum situ destroy symbionts. As result, ROS resistance CRC through elevated autophagy mediated relieved, contributing apoptosis cells induced intracellular redox imbalance generated SAN. Particularly, experiences renal clearance, avoiding long-term systemic toxicity. work provides feasible paradigm block antitumor an optimized trail clearable

Language: Английский

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The role of hyaluronic acid in the design and functionalization of nanoparticles for the treatment of colorectal cancer

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 320, P. 121257 - 121257

Published: Aug. 3, 2023

Language: Английский

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