Intratumoural microbiome can predict the prognosis of hepatocellular carcinoma after surgery

Clinical and Translational Medicine, Journal Year: 2023, Volume and Issue: 13(7)

Published: July 1, 2023

The dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics the tumour microenvironment (TME). Recent studies have confirmed presence and potential influence microbiome in TME on cancer progression. Elucidating relationship between microbes could provide valuable insights into novel diagnostic markers therapeutic strategies for HCC thus warrants a closer investigation role intratumoural TME.

Language: Английский

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Intratumor microbiota in cancer pathogenesis and immunity: from mechanisms of action to therapeutic opportunities

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 6, 2023

Microbial species that dwell human bodies have profound effects on overall health and multiple pathological conditions. The tumor microenvironment (TME) is characterized by disordered vasculature, hypoxia, excessive nutrition immunosuppression. Thus, it a favorable niche for microbial survival growth. Multiple lines of evidence support the existence microorganisms within diverse types cancers. Like gut microbiota, intratumoral microbes been tightly associated with cancer pathogenesis. Intratumoral microbiota can affect development through various mechanisms, including induction host genetic mutation, remodeling immune landscape regulation metabolism oncogenic pathways. Tumor-associated modulate efficacy anticancer therapies, suggesting their potential utility as novel targets future intervention. In addition, growing body has manifested diagnostic, prognostic, therapeutic in cancer. Nevertheless, our knowledge diversity biological function still incomplete. A deeper appreciation microbiome will be crucial to delineate key mechanisms underlying progression hasten personalized treatment approaches. Herein, we summarize most recent progress research into emerging roles towards clarifying sophisticated involved. Moreover, discuss effect response highlight its clinical implications

Language: Английский

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Intratumoral microbiota: implications for cancer onset, progression, and therapy

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.

Language: Английский

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Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 26, 2024

Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.

Language: Английский

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Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 59 - 76

Published: Jan. 1, 2025

The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. Intratumoral microorganism not only influences tumorigenesis progression, but also serves as potential biomarkers targets for therapy. Targeted manipulation these microorganisms holds great promise personalized However, there is a lack systematic summaries reports the study hepatocellular carcinoma. This comprehensive review aims address this gap by summarizing research progress related field carcinoma bacteria, including their sources, types, distribution characteristics within development, underlying mechanisms, application prospects. Through analysis, it proposed that intratumor organisms can be used markers diagnosis treatment, drug carrier materials targeting tissues, prospects developing new combination therapies based in-depth understanding interactions between microenvironment, immune cells, etc. well exploring interactions. It hoped perspective theoretical support provided future targeted therapy insights ideas points methods research.

Language: Английский

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Unveiling the Intratumor Microbiome in Liver Cancer: Current Insights and Prospective Applications

Clinical and Molecular Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

The role of the gut microbiome in development and progression liver cancer has long been recognized.However, presence microbes tumors that were previously considered sterile only recently discovered.The intratumor likely originates from various sources, including gut, hematogenous spread other mucosal locations, adjacent non-cancerous tissues, co-metastasis with tumor cells.As a newly discovered component microenvironment, it regulates host immune responses, promotes chronic inflammation, modulates metabolic pathways, exerts influences cancer.These unique features offer potential new biomarkers for prognosis treatment response.Exploring complex interactions between to modulate or target may provide avenues treatment.This article provides comprehensive review our current understanding regarding origins cancer, its characteristics, underlying mechanisms by which affects cancer.Furthermore, we discuss promising clinical implications challenges remain before this knowledge can be fully integrated into practice.

Language: Английский

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Research progress on the impact of intratumoral microbiota on the immune microenvironment of malignant tumors and its role in immunotherapy

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 5, 2024

Microbiota has been closely related to human beings, whose role in tumor development also widely investigated. However, previous studies have mainly focused on the gut, oral, and/or skin microbiota. In recent years, study of intratumoral microbiota become a hot topic tumor-concerning studies. Intratumoral plays an important occurrence, development, and response treatment malignant tumors. fact, increasing evidence suggested that is associated with tumors various ways, such as promoting affecting efficacy chemotherapy immunotherapy. this review, impact immune microenvironment analyzed, well its immunotherapy, hope it may contribute diagnostic tools treatments for future.

Language: Английский

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Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

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Awareness of intratumoral bacteria and their potential application in cancer treatment

Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 6, 2023

Abstract Hitherto, the recognition of microbiota role in tumorigenesis and clinical studies mostly focused on intestinal flora. In contrast to gut microbiome, microorganisms resident tumor tissue are close contact with cancer cells therefore have potential similar or even different functional patterns Some investigations shown intratumoral bacteria, which might come from commensal mucosal areas including gastrointestinal tract oral cavity, nearby normal tissues. The existence, origin, interactions bacteria microenvironment all contribute microorganism heterogeneity. Intratumoral a significant formation. They can at genetic level by secreting poisons that directly damage DNA also intimately related immune system response systemic level. an impact chemotherapy immunotherapy cancer. Importantly, various properties such as targeting ease modification make them powerful candidates for precision therapy, combining microbial therapies other is expected improve effectiveness treatment. this review, we mainly described heterogeneity sources overviewed important mechanisms they were involved progression, summarized their value oncology therapy. At last, highlight problems research field, look forward new wave using applications

Language: Английский

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The enrichment of the gut microbiota Lachnoclostridium is associated with the presence of intratumoral tertiary lymphoid structures in hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 5, 2023

Backgrounds and aims Immunotherapies have formed an entirely new treatment paradigm for hepatocellular carcinoma (HCC). Tertiary lymphoid structure (TLS) has been associated with good response to immunotherapy in most solid tumors. Nonetheless, the role of TLS human HCC remains controversial, recent studies suggest that their functional heterogeneity may relate different locations within tumor. Exploring factors influence formation provide more useful insights. However, affecting presence TLSs are still unclear. The gut microbiota can regulate host immune system is efficacy but, HCC, whether related lacks sufficient evidence. Methods We performed pathological examinations tumor para-tumor tissue sections. Based on location tissues, all patients were divided into intratumoral (It-TLS) group desertic (De-TLS) group. According grouping results, we statistically analyzed clinical, biological, features; preoperative data; postoperative features patients. Results In a retrospective study cohort 60 cases from single center, differential analysis showed compared De-TLS group, abundance Lachnoclostridium, Hungatella, Blautia, Fusobacterium, Clostridium was increased It-TLS Among them, enrichment Lachnoclostridium significant unrelated It be seen difference levels TLS. Conclusion Our findings prove Lachnoclostridium-dominated

Language: Английский

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