Published: Jan. 1, 2025
Language: Английский
Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(2)
Published: Jan. 15, 2024
Immunometabolism is a burgeoning field of research that investigates how immune cells harness nutrients to drive their growth and functions. Myeloid play pivotal role in tumor biology, yet metabolic influence on antitumor responses remains inadequately understood. This Review explores the landscape tumor-associated macrophages, including immunoregulatory roles glucose, fatty acids, glutamine, arginine, alongside tools used perturb metabolism promote immunity. The confounding inhibitors our interpretation myeloid phenotypes will also be discussed. A binary schema currently describe macrophage immunological phenotypes, characterizing inflammatory M1 as supported by glycolysis, immunosuppressive M2 oxidative phosphorylation. However, this classification likely underestimates variety states vivo. Understanding these nuances critical when developing interventional strategies. Future should focus refining drug specificity targeted delivery methods maximize therapeutic efficacy.
Language: Английский
Citations
17
Journal for ImmunoTherapy of Cancer, Journal Year: 2023, Volume and Issue: 11(8), P. e007441 - e007441
Published: Aug. 1, 2023
Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence abundant immunosuppressive cells. Tumor-associated macrophages (TAMs), as dominant population, impede antitumor response; however, underlying mechanisms have not been fully elucidated yet.Single-cell RNA sequencing analysis was performed portray macrophage landscape and revealed mechanism component 1q (C1q)+ TAMs. Malignant pleural effusion (MPE) human mouse used explore phenotypes functions C1q+ TAMs.C1q+ TAMs highly expressed multiple inhibitory molecules their high infiltration significantly correlated poor prognosis. promote MPE immunosuppression through impairing effects CD8+ T Mechanistically, enhance fatty acid binding protein 5 (FABP5)-mediated metabolism, which activate transcription factor peroxisome proliferator-activated receptor-gamma, increasing gene expression molecules. A high-fat diet increases microenvironment, whereas low-fat ameliorates these effects. Moreover, FABP5 inhibition represses tumor progression, while enhancing efficacy ICB lung cancer.C1q+ cells promoting immunosuppression. Targeting effectively alleviates enhances therapy. great potential be therapeutic target for immunotherapy.
Language: Английский
Citations
26
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7974 - 7974
Published: July 21, 2024
Gliomas, particularly glioblastoma (GBM), represent the most prevalent and aggressive tumors of central nervous system (CNS). Despite recent treatment advancements, patient survival rates remain low. The diagnosis GBM traditionally relies on neuroimaging methods such as magnetic resonance imaging (MRI) or computed tomography (CT) scans postoperative confirmation via histopathological molecular analysis. Imaging techniques struggle to differentiate between tumor progression treatment-related changes, leading potential misinterpretation delays. Similarly, tissue biopsies, while informative, are invasive not suitable for monitoring ongoing treatments. These challenges have led emergence liquid biopsy, through blood samples, a promising alternative monitoring. Presently, cerebrospinal fluid (CSF) sampling offers minimally means obtaining tumor-related information guide therapy. idea that any biofluid tests can be used screen many cancer types has huge potential. Tumors release various components into bloodstream other biofluids, including cell-free nucleic acids microRNAs (miRNAs), circulating DNA (ctDNA), cells (CTCs), proteins, extracellular vesicles (EVs) exosomes, metabolites, factors. factors been shown cross blood-brain barrier (BBB), presenting an opportunity well real-time assessment distinct genetic, epigenetic, transcriptomic, proteomic, metabolomic changes associated with brain tumors. their potential, clinical utility biopsy-based biomarkers is somewhat constrained by limitations absence standardized methodologies CSF collection, analyte extraction, analysis methods, small cohort sizes. Additionally, biopsies offer more precise insights morphology microenvironment. Therefore, objective biopsy should complement enhance diagnostic accuracy patients providing additional alongside traditional biopsies. Moreover, utilizing combination diverse biomarker may effectiveness compared solely relying one category, potentially improving sensitivity specificity addressing some existing GBM. This review presents overview latest research found in discusses diagnostic, predictive, prognostic indicators, future perspectives.
Language: Английский
Citations
13
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(9), P. 1695 - 1711
Published: Sept. 9, 2024
Language: Английский
Citations
13
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 2, 2025
Language: Английский
Citations
1
Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42242 - e42242
Published: Jan. 1, 2025
Language: Английский
Citations
1
Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 397 - 397
Published: Jan. 17, 2024
GBM accounts for most of the fatal brain cancer cases, making it one deadliest tumor types. is characterized by severe progression and poor prognosis with a short survival upon conventional chemo- radiotherapy. In order to improve therapeutic efficiency, considerable efforts have been made target various features GBM. One targetable rewired lipid metabolism that contributes tumor’s aggressive growth penetration into surrounding tissue. Lipid reprogramming allows acquire survival, proliferation, invasion benefits as well supportive modulation microenvironment. Several attempts find novel approaches exploiting metabolic in recent studies, components de novo lipogenesis, fatty acid oxidation, uptake, prostaglandin synthesis considered promising targets Emerging data also suggest significant role hence potential endocannabinoid pathway Here we review lipid-related characteristics detail highlight specific their use antitumor approaches.
Language: Английский
Citations
8
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(4), P. 189107 - 189107
Published: May 9, 2024
The functions of mitochondria, including energy production and biomolecule synthesis, have been known for a long time. Given the rising incidence cancer, role mitochondria in cancer has become increasingly popular. Activated by components released various pathways interact with each other to induce immune responses protect organisms from attack. However, play dual roles progression cancer. Abnormalities proteins, which are elementary structures closely linked oncogenesis. Both aberrant accumulation intermediates mutations enzymes result generation Therefore, targeting treat may be new strategy. Several drugs aimed at inhibiting mutated accumulated tested clinically. Here, we discuss current understanding interactions between mitochondrial functions, responses, Furthermore, as hopeful targets therapy, providing insights into future therapeutic strategies.
Language: Английский
Citations
6
Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)
Published: Aug. 3, 2023
Abstract Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment options, such as the chemotherapeutic agent, temozolomide (TMZ). However, many GBM tumors develop resistance to TMZ, which major obstacle effective therapy. Recently, dysregulated lipid metabolism has emerged an important factor contributing TMZ in GBM. The dysregulation of hallmark cancer alterations have been linked multiple aspects biology, including proliferation, migration, In this review, we aimed summarize current knowledge on TMZ-resistant GBM, key metabolites proteins involved synthesis, uptake, utilization, recent advances application metabolomics study We also discussed potential target for novel therapeutic interventions. Finally, highlighted challenges opportunities associated developing these interventions clinical use, need further research fully understand role Our review suggests that targeting may be promising approach overcome improve outcomes patients
Language: Английский
Citations
13