Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice DOI
Shiming Li, Wenliang Yan,

Kainong Sun

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(12)

Published: May 30, 2024

Norisoboldine (NOR) is a major isoquinoline alkaloid component in the traditional Chinese herbal plant Lindera aggregata (Sims) Kosterm, with previously reported anti-osteoclast differentiation and antiarthritis properties. However, roles of NOR on osteoblasts, bone marrow mesenchymal stem cells (BMSCs), osteoporosis vivo have never been well established.

Language: Английский

Oversecretion of CCL3 by Irradiation-Induced Senescent Osteocytes Mediates Bone Homeostasis Imbalance DOI Creative Commons
Fanyu Zhao, Hong Han,

Jing Wang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 249 - 249

Published: Feb. 10, 2025

Various stressors such as ionizing radiation (IR), chemotherapeutic agents, oxidative stress, and inflammatory responses can trigger the stress-induced premature senescence (SIPS) of cells in bone microenvironment, including osteocytes. However, little is known about mechanisms underlying senescent cellular regulation differentiation potential homeostasis. Here, we report a secretory change osteocytes activated by IR, its subsequent impact on osteogenic osteoclastic differentiation, cascade response. It was observed that exhibited altered biological function, persistent incomplete DNA damage repair, characteristic phenotypes after exposure to IR vitro. Meanwhile, concomitant increase CC chemokine ligand 3 (CCL3), key component senescence-associated phenotype (SASP), IR-induced osteocytes, which could further downregulate enhance cell supernatant co-culture experiments. Notably, enhancement PI3K/Akt/NF-κB signaling pathway appears be an essential driver imbalance between potentials. Taken together, these data suggest novel role CCL3 homeostatic through SASP secretion, mediated pathway.

Language: Английский

Citations

0
HuR‐positive stress granules: Potential targets for age‐related osteoporosis DOI Creative Commons
Ying Huai, Xue Wang,

Wenjing Mao

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(3)

Published: Feb. 20, 2024

Abstract Aging impairs osteoblast function and bone turnover, resulting in age‐related degeneration. Stress granules (SGs) are membrane‐less organelles that assemble response to stress via the recruitment of RNA‐binding proteins (RBPs), have emerged as a novel mechanism diseases. Here, we identified HuR bone‐related RBP aggregated into SGs facilitated osteogenesis during aging. HuR‐positive SG formation increased differentiation, overexpression mitigated reduction observed senescent osteoblasts. Moreover, positively regulated mRNA stability expression its target β‐catenin by binding recruiting SGs. As potential therapeutic target, activator apigenin (API) enhanced thus aided osteoblasts differentiation. API treatment nuclear export, SGs, translocation, contributed osteogenesis. Our findings highlight roles promoting skeletal aging lay groundwork for strategies against disorders.

Language: Английский

Citations

3
Senotherapy, cancer, and aging DOI
Lodovico Balducci, Claire Falandry, S. Monfardini

et al.

Journal of Geriatric Oncology, Journal Year: 2023, Volume and Issue: 15(4), P. 101671 - 101671

Published: Nov. 17, 2023

Language: Английский

Citations

6
3D-bioprinted anti-senescence organoid scaffolds repair cartilage defect and prevent joint degeneration via miR-23b/ELOVL5-mediated metabolic rewiring DOI
Yi Wang, Yongqing You, Hongyu Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152049 - 152049

Published: May 8, 2024

Language: Английский

Citations

1
Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice DOI
Shiming Li, Wenliang Yan,

Kainong Sun

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(12)

Published: May 30, 2024

Norisoboldine (NOR) is a major isoquinoline alkaloid component in the traditional Chinese herbal plant Lindera aggregata (Sims) Kosterm, with previously reported anti-osteoclast differentiation and antiarthritis properties. However, roles of NOR on osteoblasts, bone marrow mesenchymal stem cells (BMSCs), osteoporosis vivo have never been well established.

Language: Английский

Citations

0