Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury DOI Creative Commons
Èric Cortada, Jun Yao, Yu Xia

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 3, 2024

The immune system coordinates the response to cardiac injury and controls regenerative fibrotic scar outcomes in heart subsequent chronic low-grade inflammation associated with failure. Adult mice humans lack ability fully recover while adult zebrafish spontaneously regenerate after injury. Here we profile inflammatory cryoinjury coronary artery ligation mouse using single cell transcriptomics. We interrogate extracardiac reaction cardiomyocyte necrosis assess specific peripheral tissue stress. Cardiac macrophages play a critical role determining homeostasis by healing versus scarring. identify distinct transcriptional clusters of monocytes/macrophages (mono/Mϕ) each species find analogous pairs mice. However, myocardial is largely disparate between zebrafish. dichotomous damage murine mono/Mϕ and/or presence subtypes may underlie impaired process mammals humans. Our study furnishes direct cross-species comparison responses profibrotic models, providing useful resource fields biology cardiovascular research. Dynamic transcriptomic analyses reveal conserved upon models outcomes.

Language: Английский

Cardiac resident macrophages in cardiovascular disease: from physiology to pathology DOI Creative Commons

Jianshu Chen,

Ziwei Zhu, Yi Wang

et al.

Heart, Journal Year: 2025, Volume and Issue: unknown, P. heartjnl - 324333

Published: March 4, 2025

Cardiovascular disease (CVD) is the leading cause of death and burden worldwide. Macrophages are important components internal immune cells, which profoundly affects environmental homeostasis repair after injury. Cardiac resident macrophages have been shown to regulate a variety myocardial physiology pathological activities. Homeostatic in heart promote angiogenesis, remove ageing dying cells participate cardiac electrical conduction. However, role still not fully understood despite growing attention they received. This review provides an overview macrophage biology highlights prominent emerging interrelationships functions between CVD, aiming prove description functional diversity different CVD explore potential options them. may provide opportunities for successful therapeutic interventions improve prognosis patients with CVD.

Language: Английский

Citations

0
Targeting gut-immune-heart modulate cardiac remodeling after acute myocardial infarction DOI Creative Commons

Jinmei Yu,

Lin Zhou, Guo Li

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123606 - 123606

Published: April 1, 2025

The gut microbiota interacts with the host to regulate disease and health status. An increasing number of studies have recognized bidirectional regulation between immune cells, which plays a significant role in etiology prognosis diseases. Gut is also crucial regulatory factor cardiovascular After acute myocardial infarction, endothelial damage rapidly triggers an inflammatory response, activating system disrupting ecology, thereby affecting cardiac remodeling after infarction potentially leading heart failure. We elucidated mechanisms complex intercellular networks during infarction. Furthermore, this research examines roles microbiota, metabolites relation failure Finally, we discuss potential targeting cells as effective approach prevent treat future, through methods such dietary regulation, probiotic supplementation, transplantation.

Language: Английский

Citations

0
Tissue-Resident Macrophages in Cardiovascular Diseases: Heterogeneity and Therapeutic Potential DOI Open Access

Tianhui An,

Mengyuan Guo,

Zhaohui Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4524 - 4524

Published: May 9, 2025

Tissue-resident macrophages (TRMs) play a crucial role in maintaining tissue homeostasis and regulating immune responses. In recent years, an increasing number of studies have highlighted their central cardiovascular diseases. This review provides comprehensive overview TRMs, with particular emphasis on cardiac resident (CRMs), discussing origin, heterogeneity, functions various We conduct in-depth analysis macrophage subpopulations based C-C Chemokine Receptor Type 2 (CCR2) receptor expression, elucidating the CCR2+ promoting fibrosis remodeling, while highlighting protective CCR2− suppressing inflammation repair. atherosclerosis, we focus metabolic reprogramming polarization, revealing how pathways influence balance between pro-inflammatory M1 anti-inflammatory M2 macrophages, thereby affecting plaque stability disease progression. By summarizing roles these myocardial infarction, heart failure, other diseases, propose potential therapeutic strategies aimed at modulating different subtypes. These include targeting CCR2 signaling pathway to mitigate fibrosis, restore macrophages. Finally, highlight need for future research functional diversity molecular mechanisms human TRMs develop novel immunotherapeutic improve prognosis

Language: Английский

Citations

0
Cardiac macrophage metabolism in health and disease DOI Open Access
Benjamin J. Kopecky, Kory J. Lavine

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 35(3), P. 249 - 262

Published: Nov. 21, 2023

Language: Английский

Citations

9
Immunometabolism, extracellular vesicles and cardiac injury DOI Creative Commons
Ana Carolina Mieko Omoto, Jussara M. do Carmo, Alexandre A. da Silva

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Recent evidence from our lab and others suggests that metabolic reprogramming of immune cells drives changes in cell phenotypes along the inflammatory-to-reparative spectrum plays a critical role mediating inflammatory responses to cardiac injury (e.g. hypertension, myocardial infarction). However, factors drive are not fully understood. Extracellular vesicles (EVs) recognized for their ability transfer cargo such as microRNAs remote sites influence remodeling. Furthermore, conditions obesity syndrome, which implicated majority cardiovascular disease (CVD) cases, can skew production EVs toward pro-inflammatory phenotypes. In this mini-review, we discuss mechanisms by may metabolism during associated with syndrome disrupt normal EV function. We also potential sources cardio-protective anti-inflammatory EVs, brown adipose tissue. Finally, implications future therapeutics.

Language: Английский

Citations

3
Immunomodulatory Therapy for Ischemic Heart Disease DOI

X. Zhao,

Thomas Williamson, Yanqing Gong

et al.

Circulation, Journal Year: 2024, Volume and Issue: 150(13), P. 1050 - 1058

Published: Sept. 23, 2024

Ischemic heart disease is a leading cause of death worldwide, manifested clinically as myocardial infarction (and ischemic cardiomyopathy. Presently, there exists notable scarcity efficient interventions to restore cardiac function after infarction. Cumulative evidence suggests that impaired tissue immunity within the microenvironment aggravates dysfunction, contributing progressive failure. Recent research breakthroughs propose immunotherapy potential approach by leveraging immune and stroma cells recalibrate microenvironment, holding significant promise for treatment disease. In this Primer, we highlight three emerging strategies immunomodulatory therapy in managing cardiomyopathy: targeting vascular endothelial rewire immunity, reprogramming myeloid bolster their reparative function, utilizing adoptive T cell ameliorate fibrosis. We anticipate will offer exciting opportunities treatment.

Language: Английский

Citations

1
Human and gut microbiota synergy in a metabolically active superorganism: a cardiovascular perspective DOI Creative Commons
Matteo Antonio Russo, Matteo Puccetti, Claudio Costantini

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 11, 2024

Despite significant advances in diagnosis and treatment over recent decades, cardiovascular disease (CVD) remains one of the leading causes morbidity mortality Western countries. This persistent burden is partly due to incomplete understanding fundamental pathogenic mechanisms, which limits effectiveness current therapeutic interventions. In this context, evidence highlights pivotal role immuno-inflammatory activation by gut microbiome influencing disorders, potentially opening new avenues. Indeed, while atherosclerosis has been established as a chronic inflammatory arterial wall, accumulating data suggest that immune system regulation anti-inflammatory pathways mediated microbiota metabolites play crucial range CVDs, including heart failure, pericardial disease, arrhythmias, cardiomyopathies. Of particular interest emerging how tryptophan metabolism-by both host microbiota-converges on Aryl hydrocarbon Receptor (AhR), key regulator homeostasis. review seeks enhance our inflammation CVD, with focus microbiome-derived metabolites, such indoles their derivatives, contribute cardioimmunopathology. By exploring these we aim facilitate development novel, microbiome-centered strategies for combating CVD.

Language: Английский

Citations

1
Editorial: Transcriptional regulation in cardiovascular diseases DOI Creative Commons

Yali Nie,

Chao Song, Huifang Tang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 17, 2024

Cardiovascular diseases are the most dangerous diseases, which can cause dysfunction of human circulatory system, and eventually lead to an increased risk sudden cardiac death. Crea, (2023, Padro et al., (2023). Emerging evidence revealed that transcriptional mis-regulation induced abnormal gene expression is one major causes multiple cardiovascular diseases. Disse The anti-inflammatory pro-inflammatory properties macrophages make research model multidisciplinary interaction a prospective promising form suitable for development mechanism research.Using principles technologies bioinformatics process genes, In summary, this topic aims provide new discoveries insights on regulation (such as myocardial infarction, heart failure, hypertrophy, etc.), in anticipation therapeutic targets or strategies treatment above series topics also highlights importance linkage between molecular biology experiments analysis techniques

Language: Английский

Citations

1
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival DOI Creative Commons
Collin Z. Jordan, Matthew Tunbridge, Irma Husain

et al.

JCI Insight, Journal Year: 2024, Volume and Issue: 9(5)

Published: Jan. 23, 2024

Innate immune cells are important in the initiation and potentiation of alloimmunity transplantation. Immediately upon organ anastomosis reperfusion, recipient monocytes enter graft from circulation differentiate to inflammatory macrophages promote allograft inflammation. However, factors that drive their differentiation not understood. Here, we show receptor tyrosine kinase AXL was a key driver early intragraft infiltrating presence allogeneic stimulation cell-to-cell contact. In this context, differentiated were capable efficient alloantigen presentation allostimulation T indirect pathway. Consequently, transient inhibition with pharmacological inhibitor bemcentinib resulted profound reduction initial inflammation significant prolongation survival murine heart transplant model. Our results support further investigation as part an induction regimen for

Language: Английский

Citations

1
Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration DOI Creative Commons

Kexiao Zheng,

Yanglin Hao,

Chenkun Xia

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 10, 2024

The adult mammalian cardiomyocyte has a limited capacity for self-renewal, which leads to the irreversible heart dysfunction and poses significant threat myocardial infarction patients. In past decades, research efforts have been predominantly concentrated on proliferation regeneration. However, is complex organ that comprises not only cardiomyocytes but also numerous noncardiomyocyte cells, all playing integral roles in maintaining cardiac function. addition, are exposed dynamically changing physical environment includes oxygen saturation mechanical forces. Recently, growing number of studies microenvironment regeneration ongoing. this review, we provide an overview recent advances microenvironment, plays important role

Language: Английский

Citations

1