Effects of Intermittent Fasting on Health, Aging, and Disease

New England Journal of Medicine, Journal Year: 2019, Volume and Issue: 381(26), P. 2541 - 2551

Published: Dec. 25, 2019

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, longevity, decreased incidence of diseases, including cancer obesity.

Language: Английский

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Oct. 7, 2020

Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells adapt environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation xenobiotics. These effects are mainly achieved by driving effect of NAD on metabolic pathways enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple -dependent enzymes involved physiology either post-synthesis chemical modification DNA, RNA proteins, or releasing second messenger cyclic ADP-ribose (cADPR) NAADP . Prolonged disequilibrium metabolism disturbs physiological functions, resulting diseases diseases, cancer, aging neurodegeneration disorder. In this review, we summarize recent advances our understanding molecular mechanisms -regulated responses stresses, contribution deficiency various via manipulating cellular communication networks potential new avenues for therapeutic intervention.

Language: Английский

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Cellular senescence and senolytics: the path to the clinic

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(8), P. 1556 - 1568

Published: Aug. 1, 2022

Language: Английский

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Modulation of cellular processes by histone and non-histone protein acetylation

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(5), P. 329 - 349

Published: Jan. 18, 2022

Language: Английский

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Hallmarks of Health

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 33 - 63

Published: Dec. 18, 2020

Language: Английский

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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(3), P. 462 - 476.e6

Published: Aug. 27, 2019

Language: Английский

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Biological Versus Chronological Aging

Journal of the American College of Cardiology, Journal Year: 2020, Volume and Issue: 75(8), P. 919 - 930

Published: Feb. 24, 2020

Aging is the main risk factor for vascular disease and ensuing cardiovascular cerebrovascular events, leading causes of death worldwide. In a progressively aging population, it essential to develop early-life biomarkers that efficiently identify individuals who are at high developing accelerated damage, with ultimate goal improving primary prevention reducing health care socioeconomic impact age-related disease. Studies in experimental models humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies extend span life require understanding interindividual differences age-dependent functional decline, known as biological This review summarizes current knowledge on age biomarkers, factors influencing aging, antiaging interventions, focus aspects process its related manifestations.

Language: Английский

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Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: March 26, 2020

Mitochondrial dysfunction constitutes one of the hallmarks aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation DNA (mtDNA) mutations, increased production reactive oxygen species (ROS) consequent oxidative damage to nucleic acids, proteins lipids. Mitophagy, a quality control mechanism enabling degradation damaged superfluous mitochondria, prevents such detrimental effects reinstates cellular homeostasis in response stress. To date, there increasing evidence that mitophagy significantly impaired several human pathologies including age-related diseases as neurodegenerative disorders, cardiovascular cancer. Therapeutic interventions aiming at induction may have potency ameliorate these dysfunctions. In this review, we summarize recent findings on mechanisms controlling its role development pathologies.

Language: Английский

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The genetics of human ageing

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 21(2), P. 88 - 101

Published: Nov. 5, 2019

Language: Английский

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Autophagy and the hallmarks of aging

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101468 - 101468

Published: Sept. 24, 2021

Language: Английский

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