From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior

Current Psychiatry Reports, Journal Year: 2024, Volume and Issue: 26(6), P. 312 - 322

Published: May 8, 2024

In this narrative review we wanted to describe the relationship of autonomic nervous system activity with social environment and suicidal spectrum behaviors. Patients ideation/suicide attempt have higher sympathetic (SNS) lower parasympathetic (PNS) in resting conditions during acute stress tasks compared patients without attempt. Death by suicide violent also are related SNS hyperactivation. Similarly, a SNS/PNS imbalance has been observed people childhood trauma, stressful life events or feelings loneliness isolation. Social support seems increase PNS control resilience. Due importance context behavior, could act as mediator be source relevant biomarkers. Childhood trauma may impair response patients. Loneliness, isolation moderators situations.

Language: Английский

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Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: a Swedish national study

Psychological Medicine, Journal Year: 2021, Volume and Issue: 53(4), P. 1639 - 1648

Published: Sept. 2, 2021

Abstract Background How does genetic liability to suicide attempt (SA), death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use (AUD), and drug (DUD) impact on risk for SA SD? Methods In the Swedish general population born 1932–1995 followed through 2017 ( n = 7 661 519), we calculate family scores (FGRS) SA, SD, MD, BD, SZ, AUD, DUD. Registration SD was assessed from national registers. Results univariate multivariate models predicting FGRS were highest DUD, MD. strongest SD. models, AUD higher in while SZ Higher all disorders significantly predicted both younger age at first frequency of attempts. For later Mediation effects more pronounced than weakest Conclusions our five psychiatric a complex manner. While some factors is mediated developing disorders, these risks also predispose directly suicidal behaviors.

Language: Английский

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Genetic contributions to suicidal thoughts and behaviors

Psychological Medicine, Journal Year: 2021, Volume and Issue: 51(13), P. 2148 - 2155

Published: May 25, 2021

Abstract Suicidal ideation, suicide attempt (SA) and are significantly heritable phenotypes. However, the extent to which these phenotypes share genetic architecture is unclear. This question of great relevance determining key risk factors for suicide, alleviate societal burden suicidal thoughts behaviors (STBs). To help address heterogeneity, consortia efforts have recently shifted from a focus on within context major psychopathology (e.g. depressive disorder, schizophrenia) as an independent entity. Recent molecular studies by members Psychiatric Genomics Consortium International Suicide Genetics identified genome-wide significant loci associated with SA death, examined outside psychopathology. review summarizes important insights epidemiological biometrical research discusses empirical findings examinations STBs. Polygenic scores been observed be case−control status other In addition, estimated shared covariance suggests specific medical psychiatric risks beyond disorder. Broadly, suggest complexity etiology that cannot simply accounted depression. Discussion state genetics, growing field, also includes ethical clinical implications studying suicide.

Language: Английский

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Psychosocial and psychiatric factors preceding death by suicide: A case–control psychological autopsy study involving multiple data sources

Suicide and Life-Threatening Behavior, Journal Year: 2022, Volume and Issue: 52(5), P. 1037 - 1047

Published: July 11, 2022

A range of factors including mental disorders and adverse life events can increase the risk suicide. The objectives this study were to examine psychosocial psychiatric service engagement among suicide decedents compared with living controls.A case-control using multiple sources was conducted. Information on 132 consecutive cases drawn from coronial files, interviews carried out 35 family informants 53 controls. GPs completed questionnaires for 60 27 controls.The majority (83.3%) had contacted a GP in year prior death, while 23.3% 10 or more consultations during death. Half history self-harm. Suicide significantly likely than controls have diagnosis (60% vs. 18.5%) depressive illness (36.7% 14.8%). Over one-quarter been treated as inpatient.Primary care providers should be supported deliver multidisciplinary interventions engage, assess, treat patients at suicide, targeting those who present very frequently, self-harm substance misuse, psychological presentations.

Language: Английский

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Association of sociodemographic, proximal, and distal clinical factors with current suicidal ideation: Findings from a nonclinical sample of young adults

European Psychiatry, Journal Year: 2023, Volume and Issue: 66(1)

Published: Jan. 1, 2023

Abstract Background Accumulating evidence indicates that a variety of distal and proximal factors might impact risk suicide. However, the association between both groups remains unknown. Therefore, in present study, we aimed to investigate interplay correlates current suicidal ideation. Methods A total 3,000 individuals (aged 18–35 years, 41.7% males), who had reported negative history psychiatric treatment, were enrolled through an online computer-assisted web interview. Self-reports administered measure: (a) factors: childhood trauma (CT), reading disabilities (RDs), symptoms attention-deficit/hyperactivity disorder (ADHD), lifetime non-suicidal self-injury (NSSI), problematic substance use as well family schizophrenia mood disorders; (b) depressive symptoms, psychotic-like experiences (PLEs), insomnia; (c) sociodemographic characteristics. Results Suicidal ideation was directly associated with unemployment, being single, higher level RD, NSSI severity PLEs, depression, insomnia. The fully (a CT ADHD) or partially RD) mediated by (PLEs, insomnia). Conclusions Main findings from this study posit role related neurodevelopmental disorders, shaping suicide risk. Their effects be

Language: Английский

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