Childhood Maltreatment and Depression: The Role of Emotion Regulation and Irrational Beliefs DOI Open Access
Aslı Burçak TAŞÖREN

OPUS Toplum Araştırmaları Dergisi, Journal Year: 2025, Volume and Issue: 22(1), P. 46 - 63

Published: Feb. 16, 2025

Numerous factors contribute to the relationship between childhood maltreatment and depressive symptoms in later life, with emotion dysregulation being a key component. This study explored mediating role of difficulties regulation irrational beliefs symptoms. The Childhood Trauma Questionnaire (CTQ), Beck Depression Inventory (BDI), Difficulties Emotion Regulation Scale (DERS-16), Shortened General Attitude Belief (SGABS) were administered total 354 participants aged 18-61. Structural equation modeling (SEM) was employed test several models. initial model proposed that link depression would be mediated by beliefs. results indicated did not fit data showed no significant depression, leading its removal from model. In subsequent models, subscales CTQ examined. found fully mediate emotional abuse, sexual physical while partially neglect subscales. Results highlight importance understanding multiple mechanisms involved adult symptomatology.

Language: Английский

Assessing the Role of Cortisol in Anxiety, Major Depression, and Neuroticism: A Mendelian Randomization Study Using SERPINA6/SERPINA1 Variants DOI Creative Commons
Io Ieong Chan, Anise M. S. Wu

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 4(3), P. 100294 - 100294

Published: Feb. 18, 2024

Previous evidence informed by the toxic stress model suggests that higher cortisol causes anxiety and major depression, but clinical success is lacking. To clarify role of cortisol, we used Mendelian randomization to estimate its associations with anxiety, neuroticism, leveraging largest available genome-wide association studies including from Psychiatric Genomics Consortium, UK Biobank, FinnGen.

Language: Английский

Citations

8
Intervening After Trauma: Child–Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration DOI Creative Commons
Alexandra D. W. Sullivan, Sarah M. Merrill, Chaini Konwar

et al.

Psychological Science, Journal Year: 2024, Volume and Issue: 35(9), P. 1062 - 1073

Published: Aug. 14, 2024

Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related lower epigenetic age acceleration, trauma-sensitive biomarker accelerated biological aging that is associated with later impairment, sample children trauma histories. Within this quasi-experimental, repeated-measures study, we examined acceleration at baseline postintervention low-income receiving CPP treatment (

Language: Английский

Citations

7
Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies DOI
Avshalom Caspi, Gemma Shireby, Jonathan Mill

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(11), P. 1038 - 1047

Published: Nov. 2, 2023

Language: Английский

Citations

15
Understanding patch foraging strategies across development DOI Creative Commons
Alex Lloyd, Essi Viding, Ryan McKay

et al.

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(11), P. 1085 - 1098

Published: July 25, 2023

Patch foraging is a near-ubiquitous behaviour across the animal kingdom and characterises many decision-making domains encountered by humans. We review how disposition to explore in adolescence may reflect evolutionary conditions under which hunter-gatherers foraged for resources. propose that neurocomputational mechanisms responsible reward processing, learning, cognitive control facilitate transition from exploratory strategies exploitative adulthood - where individuals capitalise on known This developmental be disrupted psychopathology, as there emerging evidence of biases explore/exploit choices mental health problems. Explore/exploit an informative marker development future research should consider this feature target clinical intervention.

Language: Английский

Citations

14
Do dimensions of childhood adversity differ in their direct associations with youth psychopathology? A meta-analysis DOI Creative Commons
Amy Hyoeun Lee, Yukihiro Kitagawa, Rebecca Mirhashem

et al.

Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: April 8, 2024

Growing evidence supports the unique pathways by which threat and deprivation, two core dimensions of adversity, confer risk for youth psychopathology. However, extent to these differ in their direct associations with psychopathology remains unclear. The primary aim this preregistered meta-analysis was synthesize between threat, internalizing, externalizing, trauma-specific Because is proposed be directly linked socioemotional development, we hypothesized that magnitude would larger than those deprivation. We conducted a search peer-reviewed articles English using PubMed PsycINFO databases through August 2022. Studies assessed both deprivation used previously validated measures were included. One hundred twenty-seven included synthesis (

Language: Английский

Citations

5
DNA methylation as a possible causal mechanism linking childhood adversity and health: Results from two-sample mendelian randomization study DOI
Isabel K. Schuurmans, Erin C. Dunn, Alexandre A. Lussier

et al.

American Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 193(11), P. 1541 - 1552

Published: May 17, 2024

Abstract Childhood adversity is an important risk factor for adverse health across the life course. Epigenetic modifications, such as DNA methylation (DNAm), are a hypothesized mechanism linking to disease susceptibility. Yet, few studies have determined whether adversity-related DNAm alterations causally related future outcomes or if their developmental timing plays role in these relationships. Here, we used 2-sample mendelian randomization obtain stronger causal inferences about association between adversity-associated loci development (ie, birth, childhood, adolescence, and young adulthood) 24 mental, physical, behavioral outcomes. We identified particularly strong associations attention-deficit/hyperactivity disorder, depression, obsessive-compulsive suicide attempts, asthma, coronary artery disease, chronic kidney disease. More of were birth childhood DNAm, whereas adolescent adulthood more closely linked mental health. also had primarily risk-suppressing relationships with outcomes, suggesting that might reflect compensatory buffering mechanisms against rather than acting solely indicator risk. Together, our results suggest both physical impacts differences emerging earlier development.

Language: Английский

Citations

5
Childhood maltreatment and non-suicidal self-injury in adolescent population: A systematic review and meta-analysis DOI Creative Commons
Natàlia Calvo, Jorge Lugo‐Marín,

Monterrat Oriol

et al.

Child Abuse & Neglect, Journal Year: 2024, Volume and Issue: 157, P. 107048 - 107048

Published: Sept. 26, 2024

Language: Английский

Citations

5
The Continuity of Adversity: Negative Emotionality Links Early Life Adversity With Adult Stressful Life Events DOI
Grace M. Brennan, Terrie E. Moffitt, Kyle J. Bourassa

et al.

Clinical Psychological Science, Journal Year: 2024, Volume and Issue: 12(6), P. 1111 - 1126

Published: Jan. 11, 2024

Adversity that exhibits continuity across the life course has long-term detrimental effects on physical and mental health. Using 920 participants from Dunedin Study, we tested following hypotheses: (a) Children (ages 3–15) who experienced adversity would also tend to experience in adulthood 32–45), (2) interim personality traits young 18–26) help account for this longitudinal association. more tended stressful events as adults, β = 0.11, 95% confidence interval [CI] [0.04, 0.18], p .002. Negative emotionality—particularly its subfacet alienation, characterized by mistrust of others—helped explain childhood-to-midlife association (indirect effect: 0.06, CI 0.09], < .001). Results were robust adjustment sex, socioeconomic origins, childhood IQ, preschool temperament, other young-adult traits. Prevention early treatment negative emotionality may reduce vulnerability later stress thereby promote health aging adults.

Language: Английский

Citations

4
Nonshared environment: Real but random DOI Creative Commons
Robert Plomin

JCPP Advances, Journal Year: 2024, Volume and Issue: 4(3)

Published: Feb. 22, 2024

In the excitement about genomics, it is easy to lose sight of one most important findings from behavioural genetics: At least half variance psychopathology caused by environmental effects that are not shared children growing up in same family, which includes error measurement. However, a 30-year search for systematic causes nonshared environment line-up usual suspects, especially parenting, has identified culprits.

Language: Английский

Citations

4
Childhood trauma and somatic and mental illness in adulthood—findings of the NAKO health study DOI
Johanna Klinger-König, Angelika Erhardt, Fabian Streit

et al.

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 22, 2023

Childhood trauma is associated with somatic and mental illness in adulthood. The strength of the association varies as a function age, sex, type trauma. Pertinent studies to date have mainly focused on individual diseases. In this study, we investigate between childhood multiplicity illnesses

Language: Английский

Citations

11