Race to invade: Understanding soft tissue integration at the transmucosal region of titanium dental implants

Dental Materials, Journal Year: 2021, Volume and Issue: 37(5), P. 816 - 831

Published: March 5, 2021

Language: Английский

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Microbial diagnostics in periodontal diseases

Periodontology 2000, Journal Year: 2024, Volume and Issue: 95(1), P. 176 - 193

Published: May 26, 2024

Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding subgingival community dynamics. Certain pathobionts can orchestrate establishment dysbiotic communities that subvert host immune system, triggering inflammation and tissue destruction. Yet, diagnosis management conditions still rely on clinical radiographic examinations, overlooking well-established etiology. This review summarizes chronological emergence etiological models co-evolution with technological advances detection. We additionally approaches currently accessible to clinicians, highlighting their value broadening assessment. The epidemiological importance obtaining culture-based antimicrobial susceptibility profiles taxa for antibiotic resistance surveillance is also underscored, together clinically relevant guide antibiotherapy choices, when necessary. Furthermore, 16S-based shotgun metagenomic profiling discussed outlining signatures. Because dysbiosis precedes damage, biomarker identification offers early diagnostic possibilities forestall disease relapses during maintenance. Altogether, this highlights underutilized potential microbiology periodontology, spotlighting areas most conductive its implementation enhancing prevention, treatment predictability, addressing global resistance.

Language: Английский

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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 11, 2025

The oral microbiome comprises over 700 distinct species, forming complex biofilms essential for maintaining and systemic health. When the microbial homeostasis in periodontium is disrupted, pathogens within biofilm can cause periodontitis peri-implantitis, inducing host immune responses. Understanding role of communities mechanisms health disease crucial developing improved preventive, diagnostic therapeutic strategies. However, many questions remain about how changes bacterial populations contribute to development progression these conditions. An electronic manual literature search was conducted using PubMed, Excerpta Medica, Frontiers Reports Wiley Online Library databases relevant articles. Data from publications were extracted overall findings summarized a narrative manner. variations responses peri-implantitis are explored. Dysbiosis subgingival microbiome—characterized by an increase pathogenic bacteria such as Porphyromonas gingivalis , Tannerella forsythia Aggregatibacter actinomycetemcomitans —plays pivotal initiation periodontitis. As alterations include higher abundance opportunistic reduced diversity around implants. Moreover, dysbiosis potentially influencing through immune-mediated pathways. Regional immunity involving neutrophils, T helper cells-17, immune-related cytokines periodontal responding imbalances. Additionally, impact non-mechanical treatments—such probiotics laser therapy—on discussed, demonstrating their potential managing dysbiosis. These underscore that central factor peri-implantitis. Maintaining balance preventing diseases, interventions targeting could enhance treatment outcomes. Strategies focusing on controlling bacteria, modulating responses, promoting tissue regeneration key restoring stability. Further research needed clarify underlying transition peri-implant mucositis optimize prevention approaches, considering interactions between immunity.

Language: Английский

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Oral Microbiota in Patients with Peri-Implant Disease: A Narrative Review

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(7), P. 3250 - 3250

Published: March 23, 2022

Peri-implant infections are the most common complications related to placement of dental implants. There many microbial similarities between peri-implantitis and periodontitis but due current laboratory techniques there just as differences. This review was performed assess changes in oral microbiota at sites with peri-implant disease, according state art. The presents a lower quality than periodontal microbiota, becoming increasingly complex it progresses from mucositis peri-implantitis. difference detected is primarily whole bacterial populations, rather specific taxa. use probiotics could support reduction pockets, association mechanical debridement, their mechanism action competitive inhibition for adhesion sites. represents qualitatively inferior quantitatively superior ecosystem some genera compared showing that progression healthy causes composition absence disease-causing bacteria. Transcriptomics provide useful information prevention, diagnosis, therapy pathology through knowledge virulence factors.

Language: Английский

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Fitting pieces into the puzzle: The impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections

Advances in Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 298, P. 102551 - 102551

Published: Oct. 21, 2021

Language: Английский

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Host-microbiome interactions regarding peri-implantitis and dental implant loss

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Sept. 22, 2022

In the last decades, ortho-aesthetic-functional rehabilitation had significant advances with advent of implantology. Despite success in implantology surgeries, there is a percentage failures mainly due to loco infections, through bacterial proliferation, presence fungi and biofilm formation, originating peri-implantitis. this sense, several studies have been conducted since then, seeking answers numerous questions that remain unknown. Thus, present work aims discuss interaction between host-oral microbiome development Peri-implantitis was associated diversity species, being Porphiromonas gingivalis, Treponema denticola Tannerella forsythia described higher proportion peri-implantitis samples. parallel role, injury peri-implant tissue causes an inflammatory response mediated by activation innate immune cells such as macrophages, dendritic cells, mast neutrophils. summary, host system may lead imbalance oral microbiota, and, turn, microbiota dysbiosis reported leading cytokines, chemokines, prostaglandins, proteolytic enzymes production. These biological processes be responsible for implant loss.

Language: Английский

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Influence of cadmium and microplastics on physiological responses, ultrastructure and rhizosphere microbial community of duckweed

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 243, P. 114011 - 114011

Published: Aug. 22, 2022

The combined contamination of heavy metals and microplastics is widespread in freshwater environments. However, there are few researches on their effects aquatic plants. In this study, the single stress 0.01 mg L-1 cadmium (Cd), 50 polyethylene polypropylene for 15 days physiological response, ultrastructure rhizosphere microbial community duckweed were investigated. results showed that Cd or inhibited growth duckweed, shortened root length decreased chlorophyll content. Compared with treatments, combination increased rate superoxide dismutase activity malondialdehyde content reduced chloroplast structural damage, indicating could reduce toxicity to duckweed. Through study diversity, 1381 Operational Taxonomic Unit (OTUs) identified rich communities detected rhizosphere. Among them, main Proteobacteria, Bacteroidetes, Cyanobacteria. stress, ACE chao index under diversity abundance improved after treatment. Our revealed plants, providing a theoretical basis applications complex water pollution.

Language: Английский

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Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: March 11, 2022

Peri-implant diseases are considered to be a chronic destructive inflammatory destruction/damage occurring in soft and hard peri-implant tissues during the patient’s perennial use after implant restoration have attracted much attention because of their high incidence. Although most studies seem suggest that pathogenesis is similar periodontal both begin with microbial infection, specific mechanism remains unclear. As an oral opportunistic pathogen, Fusobacterium nucleatum ( F. ) has been demonstrated vital for occurrence development many infectious diseases, especially diseases. More notably, latest relevant may contribute Considering close connection between summary role provide more research directions ideas peri-implantation mechanism. In this review, we summarize effects on by biofilm formation, host response, then establish relationship Based above aspects, discuss importance potential value

Language: Английский

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The race for the optimal antimicrobial surface: perspectives and challenges related to plasma electrolytic oxidation coating for titanium-based implants

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 311, P. 102805 - 102805

Published: Oct. 26, 2022

Language: Английский

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Recent Clinical Treatment and Basic Research on the Alveolar Bone

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 843 - 843

Published: March 10, 2023

The periodontal ligament is located between the bone (alveolar bone) and cementum of tooth, it connected by tough fibers called Sharpey's fibers. To maintain healthy teeth, foundation supporting teeth must be healthy. Periodontal diseases, also known as tooth loss, cause alveolar to dissolve. bone, similar bones in other body parts, repeatedly resorbed osteoclasts renewed osteogenic cells. This means that an old constantly being replaced a new bone. In around absorbed, disease progresses, shrinks gradually. most cases, does not return its original form even after cured. Gum covers surface so matches shape exposing more than before, making look longer, leaving gaps some cases causing sting. Previously, only treatment for diseases was stop from progressing further before fell out, restoration condition almost impossible. However, method can help regeneration tissues destroyed their state much possible introduced. Recently, with improvements implant material properties, therapy has become indispensable dentistry important prosthetic option. Treatment methods techniques, which are mainly based on experience, have gradually accumulated scientific evidence, number indications increased. development augmentation contributed remarkably expansion indications, this been made various advances materials science. induced pluripotent stem cell (iPS) technology regenerating tissues, including expected applied such loss periodontitis. review focuses describes clinical practice, latest basic research.

Language: Английский

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