SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(1), P. e0280592 - e0280592

Published: Jan. 19, 2023

The large-scale dissemination of coronavirus disease-2019 (COVID-19) and its serious complications have pledged the scientific research communities to uncover pathogenesis mechanisms etiologic agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods unveiling such are rooted in understanding viral agent's interactions with immune system, including ability activate macrophages, due their suggested role prolonged inflammatory phases adverse responses. objective this study is test effect SARS-CoV-2-free proteins on metabolic responses macrophages. We hypothesized that SARS-CoV-2 shed during infection cycle may dynamically induce immunologic alterations an impact infected host cells. It imperative delineate context macrophages gain insight into these highly infectious viruses associated thus, expedite vaccine drug therapy advent combat infections. Human monocyte-derived were treated at different concentrations. phenotypic investigated subsequent pathways analyzed. obtained results indicated induced concentration-dependent profiles Several enriched following treatment, vitamin K, propanoate, Warburg effect. These indicate significant effects driven by residual hence be considered determinants pathogenesis. findings provide important as cells suggest a potential new method management prior vaccination.

Language: Английский

---

Subacute Thyroiditis Complicating COVID-19 Infection

Clinical Medicine Insights Case Reports, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Subacute thyroiditis (SAT) is a self-limited inflammatory disease and rare cause of thyrotoxicosis. Although the exact etiology SAT not sufficiently understood, it generally associated to viral infections. Current evidence highlights that may be potentially uncommon manifestation ongoing Coronavirus 2019 (COVID-19) infection or post-viral complication disease. Despite with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) both in resolved COVID-19 infection, ever-increasing numbers patients strengthens possibility this particular entity will more immediate concern future. The current work aims summarize approach SARS-CoV-2-associated SAT, present its pathophysiology, outline research found literature, discuss potential differential diagnoses diagnostic dilemmas through an illustrative case.

Language: Английский

---

The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study

Pathogens, Journal Year: 2024, Volume and Issue: 13(2), P. 101 - 101

Published: Jan. 24, 2024

The association between thyroid function and viral pneumonia has undergone extensive examination, yet the presence of a causal link remains uncertain. objective this paper was to employ Two-Sample Mendelian Randomization (MR) analysis investigate connections three diseases hormone indicators with COVID-19. We obtained summary statistics datasets from seven genome-wide studies (GWASs). primary method used for estimating relationships inverse-variance weighting (IVW). In addition, we employed weighted median, mode, MR-Egger, MR-PRESSO as supplementary analytical tools. Sensitivity analyses encompassed Cochran’s Q test, MR-Egger intercept MR-PRESSO. Our study revealed significant having genetic predisposition autoimmune disease (AITD) an increased susceptibility (odds ratio [OR]: 1.096; 95% confidence interval [CI]: 1.022–1.176). Moreover, it demonstrated heightened severity COVID-19 (OR susceptibility, hospitalization, critical illness, CIs 1.016, 1.001–1.032; 1.058, 1.003–1.116; 1.045, 1.010–1.081). However, no statistically associations were found TSH, FT4, subclinical hypo- or hyperthyroidism, risk incidence, (all p > 0.05). This establishes cause-and-effect relationship AITD development pneumonia, well

Language: Английский

---

Impact of COVID-19 Pandemic on Thyroid Surgery in a University Hospital in South Korea

Cancers, Journal Year: 2022, Volume and Issue: 14(17), P. 4338 - 4338

Published: Sept. 5, 2022

The COVID-19 pandemic has changed healthcare systems around the world. Medical personnel concentrated on infectious disease management and treatments for non-emergency diseases scheduled surgeries were delayed. We aimed to investigate change in severity of thyroid cancer before after outbreak Korea. collected three years data (2019, 2020, 2021) patients who received surgery a university hospital South Korea grouped them as "Before COVID-19", "After 1-year" 2-years". total number annual outpatients declined significantly both new (1303, 939, 1098 patients) follow-up (5584, 4609, 4739 patients). Clinical characteristics, including age, sex, BMI, preoperative cytology results, surgical extent, final pathologic diagnosis, not COVID-19. However, days from first visit was increased (38.3 ± 32.2, 58.3 105.2, 47.8 124.7 days, p = 0.027). Papillary carcinoma (PTC) showed proportions extrathyroidal extension, lymphatic invasion, vascular cervical lymph node metastasis. Increased tumor size observed with follicular (3.5 2.2, 4.0 1.9, 4.3 2.3 cm, 0.019). After outbreak, poor prognostic factors increased, an increase tumors observed. Due our study being confined single tertiary institution Incheon city, Korea, nationwide studies that include primary clinics should be required identify actual impact treatment.

Language: Английский

---

Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2023, Volume and Issue: 8(2), P. 33 - 42

Published: May 3, 2023

The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women acute phase of COVID-19 moderate course 12 months after disease. Materials methods . 85 aged 45 to 69 years were divided into groups: without COVID-19, not vaccinated, no antibodies (IgG) – control group (n = 15); a course, accompanied by pneumonia main 57); patients from who agreed be examined having 14); IgG blood deny any symptoms last asymptomatic 13). Using hormone replacement therapy presence disease history exclusion criteria study. Results. 75.4 % had euthyroidism, 12.3 subclinical hyperthyroidism. An increase free thyroxine (free T4) level as compared (p 0.004) 0.054) was found. There statistically significant difference stimulating between groups. C-reactive protein naturally higher 0.009) 0.001). A lower TNF-alpha found clinical signs 0.007) 0.00007). analysis correlation relationships revealed positive T4 levels (r 0.38, p 0.004). Conclusions. is associated an level, which positively correlates level. Twelve remains at

Language: Английский

---