Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications DOI Creative Commons
Zhen Wang, Huadong Liu

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 862 - 862

Published: July 19, 2024

Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in these metabolic pathways is a significant risk factor numerous acute chronic diseases, including type 2 diabetes (T2DM), Alzheimer’s disease (AD), obesity, cancer. Post-translational modifications (PTMs), which regulate protein structure, localization, function, activity, play crucial role managing cellular glucose metabolism. Among PTMs, lysine methylation stands out as key dynamic modification vital epigenetic regulation of gene transcription. Emerging evidence indicates that significantly impacts by modifying enzymes proteins. This review summarizes current understanding methylation’s regulatory mechanisms We highlight involvement methyltransferases (KMTs) demethylases (KDMs) generating abnormal signals affecting pathways. Additionally, we discuss chemical biology pharmacology KMT KDM inhibitors targeted degraders, emphasizing their clinical implications diseases such diabetes, neurodegenerative disorders, cancers. suggests targeting could be an ideal therapeutic strategy treating diseases.

Language: Английский

Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies DOI
Azhagu Madhavan Sivalingam

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102519 - 102519

Published: Sept. 1, 2024

Language: Английский

Citations

3
Structural activity of synthesized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as anticancer agents DOI Creative Commons

Abeer Mogadem,

Abrar Bayazeed,

Abdulmajeed F. Alrefaei

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 101813 - 101813

Published: Sept. 23, 2024

Language: Английский

Citations

2
Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications DOI Creative Commons
Zhen Wang, Huadong Liu

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 862 - 862

Published: July 19, 2024

Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in these metabolic pathways is a significant risk factor numerous acute chronic diseases, including type 2 diabetes (T2DM), Alzheimer’s disease (AD), obesity, cancer. Post-translational modifications (PTMs), which regulate protein structure, localization, function, activity, play crucial role managing cellular glucose metabolism. Among PTMs, lysine methylation stands out as key dynamic modification vital epigenetic regulation of gene transcription. Emerging evidence indicates that significantly impacts by modifying enzymes proteins. This review summarizes current understanding methylation’s regulatory mechanisms We highlight involvement methyltransferases (KMTs) demethylases (KDMs) generating abnormal signals affecting pathways. Additionally, we discuss chemical biology pharmacology KMT KDM inhibitors targeted degraders, emphasizing their clinical implications diseases such diabetes, neurodegenerative disorders, cancers. suggests targeting could be an ideal therapeutic strategy treating diseases.

Language: Английский

Citations

1