Toxicological and bioremediation profiling of nonessential heavy metals (mercury, chromium, cadmium, aluminium) and their impact on human health: A review

Annales de Toxicologie Analytique, Journal Year: 2024, Volume and Issue: 36(3), P. 205 - 234

Published: April 7, 2024

Language: Английский

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Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1851 - 1851

Published: Feb. 3, 2024

Cadmium (Cd) is an environmental toxicant of worldwide public health significance. Diet the main non-workplace Cd exposure source other than passive and active smoking. The intestinal absorption involves transporters for essential metals, notably iron zinc. These determine body burden because only a minuscule amount can be excreted each day. International Agency Research on Cancer listed as human lung carcinogen, but current evidence suggests that effects cancer risk extend beyond lung. A two-year bioassay demonstrated caused neoplasms in multiple tissues mice. Also, several non-tumorigenic cells transformed to malignant when they were exposed sublethal dose prolonged time. does not directly damage DNA, it influences gene expression through interactions with metals various proteins. present review highlights epidemiological studies connect enhanced neoplastic diseases chronic Cd. Special emphasis given impact stores Cd, its implications breast prevention highly susceptible groups women. Resistance cell death phenotypes acquired during Cd-induced transformation, under vitro conditions, are briefly discussed. potential role ZnT1 efflux transporter cellular acquisition tolerance cytotoxicity highlighted.

Language: Английский

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Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Published: Jan. 15, 2024

Cadmium (Cd) is an environmental toxicant of worldwide public health significance. Diet the main non-workplace Cd exposure source other than smoking. The intestinal absorption involves transporters for iron, zinc, copper, and calcium. These metal essentially determine body burden because only 0.001-0.005% accumulated in can be excreted urine each day. International Agency Research on Cancer listed as a human lung carcinogen. Current evidence, however, suggests that may increase prevalence many types cancer, notably lung, liver, breast, pancreas, kidney. A two-year bioassay mimics lifelong demonstrates caused neoplasms multiple tissues mice. Also, several non-tumorigenic cell lines underwent malignant transformation, when they were exposed to sublethal dose prolonged time. does not directly damage DNA, but it profoundly affect gene expression through its interactions with various proteins, thus viewed transcription modulator. present review highlights epidemiological studies connected enhanced risk neoplastic diseases chronic Cd. Special emphasis impact iron stores rate Cd, implications breast cancer prevention highly susceptible subpopulation groups women. Resistance death phenotypes acquired during Cd-induced cancer-cell under vitro conditions, are briefly discussed. potential role ZnT1 efflux transporter cellular acquisition tolerance cytotoxicity highlighted.

Language: Английский

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Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

Diabetes and its complications are major diseases that affect human health. Diabetic cardiovascular such as (CVDs) the of diabetes, which associated with loss cells. Pathogenically role ferroptosis, an iron-dependent cell death, cuproptosis, a copper-dependent death has recently been receiving attention for pathogenesis diabetes complications. How exposure to environmental metals affects these two metal-dependent deaths in under diabetic nondiabetic conditions remains largely unknown. As omnipresent metal, cadmium can cause oxidative stress cardiomyocytes, leading iron accumulation, glutathione depletion, lipid peroxidation, finally exacerbate ferroptosis disrupt cardiac. Moreover, cadmium-induced hyperglycemia enhance circulation advanced glycation end products (AGEs). Excessive AGEs promote upregulation copper importer solute carrier family 31 member 1 through activating transcription factor 3/transcription PU.1, thereby increasing intracellular Cu

Language: Английский

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Use of Hydroxyapatite Nanoparticles to Reduce Cd Contamination in Agricultural Soils: Effects on Growth and Development of Chenopodium quinoa Willd

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 639 - 639

Published: Jan. 10, 2025

Soil contamination and degradation have prompted extensive research into remediation techniques. A promising approach involves the use of nanoparticles, which can mitigate heavy metal contamination, such as cadmium (Cd), without adversely affecting crop development. This study evaluated effects hydroxyapatite nanoparticles (HANPs) on growth Chenopodium quinoa Willd. in soils contaminated with varying Cd contents (0, 5, 10, 25, 50 mg/kg). The results indicated that HANPs enhanced early shoot development, particularly concentrations ≥10 mg/kg, while significantly reducing accumulation plant tissues. also decreased mobility soil, retaining it fractions less available for uptake. Germination rates differed between pot experiments phytotoxicity assays, although first demonstrated greater immobilization HANP-treated soils, resulting reduced translocation to shoots. These findings highlight potential an effective tool remediating Cd-contaminated thereby improving soil pollution, safety, quality human consumption.

Language: Английский

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Environmental pollutants and rectal cancer: The impact of water contamination

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118072 - 118072

Published: March 23, 2025

Language: Английский

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Cadmium exposure and risk of pancreatic cancer: Systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319283 - e0319283

Published: April 29, 2025

Background Pancreatic cancer is one of the most lethal malignancies, characterized by a poor prognosis and limited treatment options. Increasing evidence suggests that environmental factors, including heavy metal exposure, play role in pancreatic development. Cadmium, toxic classified as Group 1 carcinogen, has been implicated progression. However, its association with remains uncertain, conflicting results from epidemiological studies. This systematic review meta-analysis aim to assess between cadmium exposure risk cancer. Methods A comprehensive literature search was conducted using multiple databases identify studies explored relationship risk. Eleven eligible were included meta-analysis. Pooled odds ratios (OR) 95% confidence intervals (CI) calculated estimate overall effect size. Heterogeneity assessed I², T², Cochran’s Q-test. Publication bias evaluated Egger’s Begg’s tests. Results The pooled analysis revealed significant cancer, an OR 2.01 (95% CI: 1.30, 2.72), indicating individuals exposed had more than twice developing compared those lower or no exposure. Substantial heterogeneity observed across (I² = 98.08%, T² 1.37, H² 52.21). Q-test also indicated (Q(10) 304.52, p 0.00). test (p 0.5040) 1.0000) showed publication bias. Conclusion demonstrates positive increased Despite considerable studies, findings suggest potential factor for Further research required explore underlying biological mechanisms develop strategies reducing particularly high-risk populations.

Language: Английский

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The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats

Human & Experimental Toxicology, Journal Year: 2024, Volume and Issue: 43

Published: Jan. 1, 2024

Background Capecitabine (CAPE), an antimetabolite chemotherapy, can induce hepatic and renal toxicity. Melatonin (MEL), a neurohormone, possesses antioxidant, anti-apoptotic anti-inflammatory effects. This study investigated the impact of MEL on capecitabine-induced Methods materials Twenty-five male Wistar rats were categorized into five groups for study. The included control group, MEL10 group (rats receiving daily intraperitoneal injections 5 mg/kg MEL), CAPE 500 weekly CAPE), + 10 group. All treated duration 6 weeks. Various hematological, serological, biochemical, histopathological assessments conducted to evaluate objective Results administration led significant liver kidney toxicity, as evidenced by elevated levels malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), well serological markers including AST, ALT, ALP, BUN, creatinine. exposure also resulted in reduction total antioxidant capacity (TAC) glutathione peroxidase (GPx) levels. Histological examination revealed hyperemia both tissues exposed CAPE. However, treatment with demonstrated positive alleviated oxidative stress, reduced enzymes, creatinine, ameliorated degenerations. increased GPx TAC Moreover, aided restoring body weight that was lost due exposure. Conclusion Our findings indicated significantly toxicity induced

Language: Английский

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The Gut Microbiota: A Key Player in Cadmium Toxicity - Implications for Disease, Interventions, and Combined Toxicant Exposures

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 88, P. 127570 - 127570

Published: Nov. 23, 2024

Language: Английский

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Melatonin may protect the gastrointestinal system from cadmium chloride toxicity during pregnancy

Toxicology Research, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 1, 2025

Cadmium is absorbed into the body through food consumption. Since intake increases during pregnancy, consumption from also increases. Melatonin, secreted by pineal gland, an antioxidant hormone with therapeutic effects. This research aims to reveal how Chloride (CdCl2) affects capacity histological and biochemical methods test effect of Melatonin in treating CdCl2-induced lesions pregnant mice's stomach small intestine. Control, CdCl2, CdCl2 + groups were created using mice (n: 6). (2 mg/kg/bw) (3 administered. The investigation was terminated after birth. Stomach intestine tissues pull out fixed 10% formaldehyde. They routinely histologically processed dyed via Hematoxylin-Eosin. appraised under light electron microscopy, analyses carried out. A one-way analysis variance (ANOVA) applied compare groups, LSD tests used for pairwise comparisons (P < 0.05). While a reduction weight noted group (P: 0.01), no decrease observed 0.02). caused pathologies such as degeneration gland cells, vacuole formation, hemorrhage stomach. Although rupture breakage villi intestine, these degenerations minimal group. significant enzyme levels; however, levels approached normal values may be effective agent gastrointestinal organs increased pregnancy.

Language: Английский

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