DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method DOI Creative Commons
Andrew Ke-Ming Lu, Shulan Hsieh,

Cheng‐Ta Yang

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 12, 2023

Resilience is a process associated with the ability to recover from stress and adversity. We aimed explore resilience-associated DNA methylation signatures evaluate abilities of risk scores discriminate low resilience (LR) individuals. The study recruited 78 young adults used Connor-Davidson Scale (CD-RISC) divide them into high groups. randomly allocated all participants two groups discovery validation sets. blood subjects conduct genome-wide scan identify significant differences CpG Sites in set. Moreover, classification accuracy probes was confirmed set by real-time quantitative methylation-specific polymerase chain reaction. In profiling between LR HR individuals, seventeen significantly differentially methylated were detected. set, nine within gene coding regions selected for verification. Finally, three [cg18565204 (AARS), cg17682313 (FBXW7), cg07167608 (LINC01107)] included final model score versus HR. These models demonstrated satisfactory discrimination logistic regression support vector machine, an AUC 0.81 0.93, 72.3% 87.1%, sensitivity 75%, 87.5%, specificity 70% 80%. Our findings suggest that can be utilized individuals establish may contribute field psychology.

Language: Английский

Resilience and mental health: how multisystemic processes contribute to positive outcomes DOI
Michael Ungar, Linda Theron

The Lancet Psychiatry, Journal Year: 2019, Volume and Issue: 7(5), P. 441 - 448

Published: Dec. 2, 2019

Language: Английский

Citations

674
Tourism resilience in the ‘new normal’: Beyond jingle and jangle fallacies? DOI Open Access
Girish Prayag

Journal of Hospitality and Tourism Management, Journal Year: 2023, Volume and Issue: 54, P. 513 - 520

Published: Feb. 22, 2023

Language: Английский

Citations

71
The role of epigenetics in psychological resilience DOI
Demelza Smeeth, Stephan Beck, Elie G. Karam

et al.

The Lancet Psychiatry, Journal Year: 2021, Volume and Issue: 8(7), P. 620 - 629

Published: April 27, 2021

Language: Английский

Citations

63
Adverse Childhood Experiences Are Associated with Reduced Psychological Resilience in Youth: A Systematic Review and Meta-Analysis DOI Creative Commons

Cyleen Morgan,

Yun‐Hsuan Chang, Olivia Choy

et al.

Children, Journal Year: 2021, Volume and Issue: 9(1), P. 27 - 27

Published: Dec. 31, 2021

Background: Adverse childhood experiences (ACEs) are presumed to influence internalizing and externalizing behaviors that can significantly debilitate long-term biopsychological development in individuals. Psychological resilience has been shown effectively mediate the relationship between ACEs negative health outcomes since individuals with low levels of may have difficulty bouncing back from toxic exposure ACEs. Thus, present systematic review meta-analysis was aimed toward synthesizing current knowledge psychological youths. Methods: A combination key words relevant study searched on PubMed, EMBASE, Scopus, Cochrane, Google Scholar databases. The results were restricted English publications human studies, subjects ranging age 0 35 years. Effect-size measures inclusive pooled correlation coefficients for analyses odds ratios regression analyses, respectively, calculated using random-effect models determine resilience. Results: searches identified 85 potentially studies. Among them, 76 excluded due limited access, irrelevant data, fact variables interest not explicitly measured or disclosed, leaving a final total nine studies considered valid meta-analysis. Findings correlational (n = 6) revealed association (β −0.120 [−0.196, −0.043]). 3) reporting dichotomous (ACE ≥ 1 vs. no ACE) indicated who experienced an ACE 63% less likely display high resilience, comparison without such experiences. Conclusion: Our support highlight multiple dimensions constitute ACE-exposure context. These findings be particularly useful policy makers healthcare institutions terms helping them devise effective medical interventions community outreach programs intended develop youths, thus reducing health-risk outcomes.

Language: Английский

Citations

55
A Review of Family Resilience: Understanding the Concept and Operationalization Challenges to Inform Research and Practice DOI

Ivana Maurović,

Linda Liebenberg, Martina Ferić

et al.

Child Care in Practice, Journal Year: 2020, Volume and Issue: 26(4), P. 337 - 357

Published: Aug. 6, 2020

Family resilience is a concept that has wide and deep roots, ranging from the development of individual to postulates general systems theory, including family theory related therapeutic models as well studies on stress coping. Integration these roots into comprehensive remains incomplete. Consequently, numerous ambiguities in conceptualization operationalization remain. This important implications for both research application practice. article aims contribute clarification understanding this evolving by reviewing foundations upon which emerged been developing. Our work connects concepts resilience, as, community presenting key challenges but also possible solutions operationalizing indicators risk, protective factors, good outcomes. discusses influence context dominant social discourses defining risk exposure adaptation, highlighting engagement core resource. The concludes remain field research, especially light relevance interventions practice pertaining child youth care

Language: Английский

Citations

54
Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions DOI Open Access
Ljiljana Trtica Majnarić, Zvonimir Bosnić, Silva Guljaš

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8970 - 8970

Published: Aug. 20, 2021

The term resilience, which has been present in science for almost half a century, stands the capacity of some system needed to overcome an amount disturbance from environment order avoid change another stable state. In medicine, concept resilience means ability deal with daily stress and our homeostasis intention protecting it disturbance. With aging, organism becomes more sensitive environmental impacts susceptible changes. Mental disturbances decline psychological older people are potentiated many social factors along subjective perception decreasing health. Distinct findings younger age groups, mental physical medical conditions closely associated each other, sharing common mechanisms potentiating other’s development. Increased inflammation oxidative have recognized as main driving development aging diseases. This paper aims reveal, through translational approach, physiological molecular emotional distress low individuals accelerated chronic diseases, systematize available information sources on strategies mitigation prevent

Language: Английский

Citations

49
A multi‐level examination of nursing students' resilience in the face of the COVID‐19 outbreak: A cross‐sectional design DOI Open Access
Anat Drach‐Zahavy, Hadass Goldblatt, Hanna Admi

et al.

Journal of Advanced Nursing, Journal Year: 2021, Volume and Issue: 78(1), P. 109 - 120

Published: July 2, 2021

To examine nursing students' stress and coping with the coronavirus disease 2019 (COVID-19) pandemic through an ecological model of resilience. Specifically, to relative contribution different resilience levels in decreasing strain symptoms: at individual level, trait; relational strategies; university perceptions on their university's readiness handle virus outbreak; national trust policymakers' decisions.

Language: Английский

Citations

42
The Molecular Basis of Resilience: A Narrative Review DOI Creative Commons
Megan Ryan,

Rebecca Ryznar

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: May 6, 2022

Resilience refers to the adaptability of a person – an ability “bounce-back” from stressors. We question if resilience can be strengthened, potentially decrease risk stress-related disorders. Unfortunately, molecular origins are complicated and not yet well understood. In this review, we examine various physiological biomarkers resilience, including associated genes, epigenetic changes, protein with resilient phenotypes. addition assessing that may indicate higher levels also review at length many confer lower lead disorders low such as anxiety depression. This large encompassing help identify possible therapeutic targets resilience. Hopefully these studies will future where prevented, rather than treated.

Language: Английский

Citations

36
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience DOI
Samata Sharma, Xénia Gonda, Péter Döme

et al.

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 214, P. 107602 - 107602

Published: June 6, 2020

Language: Английский

Citations

41
Stress: Influences and Determinants of Psychopathology DOI Creative Commons
Inês Pereira-Figueiredo, Eduardo Henrique de Lima Umeoka

Encyclopedia, Journal Year: 2024, Volume and Issue: 4(2), P. 1026 - 1043

Published: June 20, 2024

The stress response is a natural physiological reaction of the organism, elicited to maintain internal environment and evoke adaptive behaviors, ultimately leading survival. However, at turn century, stress-related disorders gained increasing significance. aim entry explore fundamental question when system changes from beneficial detrimental system, contributing higher risk development and/or diseases. To develop context, here, we different concepts reveal complexities, perspectives, multiple relationships between neurochemistry, cerebral functional network, associated pathologies. According literature, affects nearly every biological through close interactions physiological, nervous, endocrine, immune systems faced with real or perceived threat. Considering today’s challenging times, where people are facing unavoidable adversities in their lives level uncertainty never before seen, this review emphasizes importance understanding potential consequences being unable cope stressful events. Susceptibility resilience have recognition as important areas study. literature presented here enhances our identifies causes various psychopathologies, mental health conditions, disabilities, even mortality that closely linked vulnerability stress. Experimental studies recent decades demonstrated many factors affecting ability stress, including differences individuals due genetic background, epigenetic regulation, gender, early-life experiences. Finally, there an urgent need change paradigm modern lifestyles strategy prevent spread “health epidemic 21st century”, which Therefore, acknowledge approaches enhance resilience, focusing on perception, tolerance, positive lifestyle behaviors.

Language: Английский

Citations

5