Exercise as medicine in Parkinson’s disease

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2024, Volume and Issue: 95(11), P. 1077 - 1088

Published: Feb. 28, 2024

Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while symptomatic treatments have limited effects in certain domains cause side effects. Identification of interventions that prevent, slow, halt mitigate the therefore pivotal. Exercise safe represents a cornerstone rehabilitation, but exercise may even more fundamental benefits could change clinical practice. In PD, existing knowledge base supports as (1) protective lifestyle factor preventing (ie, primary prevention), (2) potential disease-modifying therapy secondary prevention) (3) effective treatment tertiary prevention). Based on current evidence, paradigm shift proposed, stating should be individually prescribed medicine persons with at early stage, alongside conventional medical treatment.

Language: Английский

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Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Multiple Sclerosis Journal, Journal Year: 2024, Volume and Issue: 30(4-5), P. 605 - 611

Published: Feb. 9, 2024

We documented reporting and rates of drop-out, adherence, compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety exercise training (ET) MS. adopted definitions metrics adherence provided by the MoXFo group. Drop-out was reported 100% RCTs approximated 10% for intervention control conditions. Adherence were approximately 50% RCTs, respectively, 80% 70%, respectively. Standardized are important future understanding impact outcomes translation research evidence into practice.

Language: Английский

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The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as signal and neuromodulator in the central nervous system (CNS). BDNF synthesized from its precursor proBDNF within CNS peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), promotes neuronal survival, synaptic plasticity, growth, whereas it inhibits microglial release pro-inflammatory cytokines. dysregulated different neurodegenerative diseases depressions. However, there major controversy concerning levels stages multiple sclerosis (MS). Therefore, this review discusses potential role signaling MS, how modulators affect pathogenesis outcomes disease.

Language: Английский

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Physical Activity in Multiple Sclerosis: Real-World Data From Saskatchewan, Canada

International Journal of MS Care, Journal Year: 2025, Volume and Issue: 27(Q1), P. 42 - 49

Published: Feb. 10, 2025

ABSTRACT BACKGROUND: Physical activity guidelines for multiple sclerosis (MS) were first published in 2013. is safe and beneficial MS, yet it unclear if physical levels are changing real-world settings. METHODS: The primary objective of this study to determine the people with MS changing. Between September 1, 2014, February 22, 2022, when accessed a provincial drugs program Saskatchewan, Canada, they invited complete Godin Leisure-Time Exercise Questionnaire by mail. Scatter plots total (TPA) health contribution (HC) scores generated from each person's questionnaire. Multivariable linear regression explored associations interactions between disease-modifying treatment (DMT), sex, age, age at onset, disease duration on level. RESULTS: response rate was 50.8% (505 responses 993 requests). Of respondents, 69.7% female; mean 42.8 (± 11.5) years; median 6.0 years (IQR, 2.0-14.0); 47.4% had prior DMT exposure. There no significant change new registrants over 7 (regression slopes TPA: 0.71, P = .26; HC: 0.61, .21). Men reported higher than women (TPA: β 11.95; < .001; 6.65; .001). 0.03; .003; exposure not associated activity. CONCLUSIONS: remained suboptimal benefits 7-year period. Future research should include how use impact levels.

Language: Английский

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Erhebung der körperlichen Aktivität bei gehfähigen Menschen mit Multipler Sklerose

psychopraxis neuropraxis, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

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Body Composition and Its Outcomes and Management in Multiple Sclerosis: Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1021 - 1021

Published: March 14, 2025

Background: There is emerging interest in obesity and its prevalence, outcomes, management people with multiple sclerosis (MS). Body mass index (BMI) the traditional marker of MS, whereas body composition, inclusive specific tissue compartments (e.g., fat, bone, muscle), often overlooked despite relevance. Objective: This narrative review (a) underscored use utility dual-energy X-ray absorptiometry (DEXA) as an accurate reliable measure composition; (b) thematically analyzed synthesized current evidence regarding composition (using DEXA); (c) determined gaps to be addressed future research. Methods: The structure reporting this followed guiding criteria outlined Scale for Assessment Narrative Review Articles (SANRA). relevant literature was identified via a PubMed search utilizing combined terms such ‘body composition’ ‘multiple sclerosis’. research then organized by authors into major themes sub-themes. articles described within were based on saturation Results: Three identified, namely (1) comparison between MS non-MS controls (2 meta-analyses); (2) examination relationships range outcomes (14 cross-sectional studies); (3) interventions that report and/or target (11 clinical trials). Conclusions: mapped existing posits novel, informative, targeted concept population. underscores importance randomized controlled trials focus significant modifiable outcome. Such could improve understanding poor identify useful recommendations diagnosis management.

Language: Английский

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Internet-based exercise and physical activity promotion for persons with multiple sclerosis: a randomized controlled trial

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 23, 2025

Abstract Background We evaluated the effects of a 12-week internet-based exercise and physical activity promotion program for persons with multiple sclerosis. Methods performed multicenter, randomized, waitlist-controlled study. The intervention group (IG) received program, followed by 12 weeks usual care. control (CG) care only. main components were: (1) tailored home-based prescription, (2) e-learning resources, (3) telephone video meetings an therapist, (4) provision consumer-based PA monitor. Measurements were taken at baseline, postintervention, after 24 weeks. primary outcome was device-measured steps/day. Other outcomes moderate-to-vigorous activity, subjectively measured leisure-time transportation sport/exercise, activity-related health competence, walking ability, quality life, fatigue, depression, PA-related self-concordance. compared changes from baseline to postintervention between groups analyzed in IG during follow-up. Results Analysis 56 sclerosis (IG: n = 29, CG: 27, age: 45.6 ± 10.9) revealed no significant effect on However, improvements observed life (physical). During follow-up, sport/exercise decreased significantly. Leisure-time increased Conclusions Our study provides first evidence that developed can increase aspects A trial larger sample is recommended confirm our results examine mechanisms. Trial registration Registry: Clinicaltrials.gov; number: NCT04367389; date registration: 2020-04-21 (retrospectively registered).

Language: Английский

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Effects of exercise training among adults with multiple sclerosis Protocol for a systematic review that informs an updated prescriptive guideline

Published: May 7, 2025

Background: Research demonstrates that exercise training is both safe and beneficial for individuals with multiple sclerosis (MS). There a timely opportunity updating the guidelines in MS, as number of RCTs examining effects on range functional biomedical outcomes among adults MS has increased substantially past decade. The evidence should be gathered through rigorous methodology, thereby ensuring comprehensive analysis. This systematic review literature will evaluate type dose necessary to improve fitness, biomarkers health disease, physical cognitive functions, symptoms quality life, and/or participation activities daily life presenting mild, moderate, or severe disability. Methods: This protocol follows PRISMA-P was registered Prospero. We undertake search conducted across 8 electronic bibliographic databases. Retrieved references screened by two authors based pre-established inclusion exclusion criteria. Relevant data extracted into piloted tables synthesized qualitatively. Methodological included studies determined using Tool Assessment Study Reporting Exercise (TESTEX). Risk bias assessed revised Cochrane risk-of-bias tool (RoB 2). Finally, certainty provided interest evaluated Grading Recommendations Assessment, Development Evaluation (GRADE) guidelines. Discussion: The analyzed this crucial our next step MS. These updated provide people their families caregivers, well care professionals services organization advocates, clear information promote patients subsequently facilitate implementation programs MS-care. Registration details: PROSPERO registration CRD42025628825

Language: Английский

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The therapeutic potential of exercise for improving mobility in multiple sclerosis

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS) with subsequent axonal neuronal degeneration. These changes are associated broad range of symptoms including skeletal muscle dysfunction. Importantly, musculoskeletal impairments manifest various ways, compromise quality life often precede later development mobility disability. As current standard modifying therapies for MS predominantly act on neuroinflammation, practitioners patients face an unmet medical need adjunct specifically targeting function. This review intended to detail nature dysfunctions common people (pwMS), describe underlying intramuscular alterations outline evidence-based therapeutic approaches. Particularly, we discuss emerging role aerobic resistance exercise reducing perception fatigue increasing strength pwMS. By integrating most recent literature, conclude that both interventions should ideally be implemented as early possible they can address MS-specific impairments. Aerobic particularly beneficial pwMS suffering from metabolic impairments, while training efficiently counters weakness improves fatigue. Thus, these lifestyle or pharmacological mimetics have potential improving general well-being delaying functional declines relevant mobility.

Language: Английский

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Allied health professionals knowledge and clinical practice in telehealth exercise behavioural change for multiple sclerosis

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 87, P. 105689 - 105689

Published: May 19, 2024

Language: Английский

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