New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

Nutrition Research Reviews, Journal Year: 2010, Volume and Issue: 23(1), P. 65 - 134

Published: June 1, 2010

Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time glycaemic response), fibre (improved faecal bulking viscosity SCFA production, and/or response) Mg (better homeostasis through increased insulin secretion), together with the antioxidant anti-carcinogenic properties numerous bioactive compounds, especially those in bran germ (minerals, trace elements, vitamins, carotenoids, polyphenols alkylresorcinols), are today well-recognised mechanisms this protection. Recent findings, exhaustive listing compounds found wheat, their content whole-grain, fractions estimated bioavailability, led to new hypotheses. involvement cell signalling gene regulation, sulfur lignin phytic acid should be considered Whole-grain wheat is also a rich source methyl donors lipotropes (methionine, betaine, choline, inositol folates) may involved cardiovascular hepatic protection, lipid metabolism DNA methylation. Potential protective bound phenolic acids within colon, B-complex vitamins on nervous system mental health, oligosaccharides as prebiotics, associated skeleton other such α-linolenic acid, policosanol, melatonin, phytosterols para -aminobenzoic deserve studied more depth. Finally, benefits nutrigenomics study complex physiological ‘whole-grain package’, most promising ways for improving nutritional quality cereal products discussed.

Language: Английский

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The role of melatonin in the cells of the innate immunity: a review

Journal of Pineal Research, Journal Year: 2013, Volume and Issue: 55(2), P. 103 - 120

Published: July 8, 2013

Melatonin is the major secretory product synthesized and secreted by pineal gland shows both a wide distribution within phylogenetically distant organisms from bacteria to humans great functional versatility. In recent years, considerable amount of experimental evidence has accumulated showing relationship between nervous, endocrine, immune systems. The molecular basis communication these systems use common chemical language. this framework, currently melatonin considered one members neuroendocrine-immunological network. A number in vivo vitro studies have documented that plays fundamental role neuroimmunomodulation. Based on information published, it clear majority present data literature relate lymphocytes; thus, they been rather thoroughly investigated, several reviews published related mechanisms action effects lymphocytes. However, few concerning cells belonging innate immunity reported. Innate provides early line defense against microbes consists cellular biochemical mechanisms. review, we focused immunity. More specifically, summarize different belong or participate immunity, such as monocytes-macrophages, dendritic cells, neutrophils, eosinophils, basophils, mast natural killer cells.

Language: Английский

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Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 18(4), P. 843 - 843

Published: April 17, 2017

There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, molecular mechanisms underpinning these inhibitory actions have been proposed. What rather perplexing, however, large number of processes by which reportedly restrains development growth. These diverse suggest what being observed are merely epiphenomena an underlying more fundamental action remains to be disclosed. Some arresting on clearly membrane receptor-mediated while others receptor-independent involve direct intracellular this ubiquitously-distributed molecule. While emphasis melatonin/cancer research has role indoleamine in restraining breast cancer, changing quickly with types having shown susceptible inhibition melatonin. several facets could immediate applications clinical level. Many studies melatonin's co-administration improves sensitivity cancers conventional drugs. Even important findings renders previously totally resistant treatment sensitive same therapies. Melatonin also inhibits associated limiting entrance cells into vascular system preventing them from establishing secondary growths distant sites. This particular importance since often significantly contributes death patient. Another area deserves additional consideration related capacity reducing toxic consequences anti-cancer drugs increasing their efficacy. Although information available for than a decade, it not adequately exploited if only beneficial patients its ability attenuate acute long-term drug toxicity, should used improve physical wellbeing patients. The experimental findings, advantages using as co-treatment therapies would far exceed improvements

Language: Английский

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Melatonin for the prevention and treatment of cancer

Oncotarget, Journal Year: 2017, Volume and Issue: 8(24), P. 39896 - 39921

Published: March 18, 2017

// Ya Li 1 , Sha 2,* Yue Zhou Xiao Meng Jiao-Jiao Zhang Dong-Ping Xu and Hua-Bin 1,3,* Guangdong Provincial Key Laboratory of Food, Nutrition Health, Department Nutrition, School Public Sun Yat-Sen University, Guangzhou, China 2 Chinese Medicine, Ka Shing Faculty The University Hong Kong, 3 South Sea Bioresource Exploitation Utilization Collaborative Innovation Center, Correspondence to: Li, email: Keywords : melatonin; anticancer; mechanisms action; receptor; apoptosis Received January 20, 2017 Accepted March 09, Published 18, Abstract epidemiological studies have indicated a possible oncostatic property melatonin on different types tumors. Besides, experimental documented that could exert growth inhibition some human tumor cells in vitro animal models. underlying include antioxidant activity, modulation receptors MT1 MT2, stimulation apoptosis, regulation pro-survival signaling metabolism, angiogenesis, metastasis, induction epigenetic alteration. Melatonin also be utilized as adjuvant cancer therapies, through reinforcing the therapeutic effects reducing side chemotherapies or radiation. an excellent candidate for prevention treatment several cancers, such breast cancer, prostate gastric colorectal cancer. This review summarized anticancer efficacy melatonin, based results epidemiological,experimental clinical studies, special attention was paid to action.

Language: Английский

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Melatonin signaling and cell protection function

The FASEB Journal, Journal Year: 2010, Volume and Issue: 24(10), P. 3603 - 3624

Published: June 9, 2010

Besides its well-known regulatory role on circadian rhythm, the pineal gland hormone melatonin has other biological functions and a distinct metabolism in various cell types peripheral tissues. In different tissues organs, been described to act as paracrine also an intracrine autocrine agent with overall homeostatic pleiotropic effects that include protection prosurvival factor. These latter effects, documented number of vitro vivo studies, are sustained through both receptor-dependent -independent mechanisms control detoxification stress response genes, thus conferring against xenobiotics endobiotics produced by acute chronic noxious stimuli. Redox-sensitive components included signaling resulting transcriptional involves NF-κB, AP-1, Nrf2. By these pathways, stimulates expression antioxidant acting turn glutathione system enhancer. A further converging mechanism this indoleamine models seems lie damage function mitochondria decreased production reactive oxygen species activation antiapoptotic redox-sensitive element Bcl2. Recent evidence suggests upstream mitochondrial route calmodulin pathway central survival-promoting component MAPKs, ERK1/2. review article, we will discuss molecular aspects relevant survival mechanisms.—Luchetti, F., Canonico, B., Betti, M., Arcangeletti, Pilolli, Piroddi, Canesi, L., Papa, S., Galli, F. Melatonin function. FASEB J. 24, 3603–3624 (2010). www.fasebj.org

Language: Английский

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Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.

Food and Chemical Toxicology, Journal Year: 2009, Volume and Issue: 48(1), P. 441 - 447

Published: Nov. 1, 2009

Language: Английский

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Melatonin and Cancer Hallmarks

Molecules, Journal Year: 2018, Volume and Issue: 23(3), P. 518 - 518

Published: Feb. 26, 2018

Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of circadian rhythm. Many studies have reported anticancer effect melatonin against myriad cancer types. Cancer hallmarks include sustained proliferation, evading growth suppressors, metastasis, replicative immortality, angiogenesis, resisting cell death, altered cellular energetics, and immune evasion. activity mediated interfering with various hallmarks. This review summarizes role in each hallmark. The discussed this should serve as solid foundation for researchers physicians to support basic clinical on promising agent.

Language: Английский

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Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

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Simultaneous modulation of COX‐2, p300, Akt, and Apaf‐1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

Journal of Pineal Research, Journal Year: 2012, Volume and Issue: 53(1), P. 77 - 90

Published: Jan. 3, 2012

Melatonin exhibits anti-inflammatory and anticancer effects could be a chemopreventive chemotherapeutic agent against cancers, but the precise mechanisms involved remain largely unresolved. In this study, we evaluated mechanism of action melatonin in human MDA-MB-361 breast cancer cells. at pharmacological concentrations (10(-3) m) significantly suppressed cell proliferation induced apoptosis dose-dependent manner. The observed suppression was accompanied by melatonin-mediated inhibition COX-2, p300, NF-κB signaling. inhibited COX-2 expression prostaglandin E(2) (PGE2) production, abrogated p300 histone acetyltransferase activity p300-mediated acetylation, thereby blocking binding recruitment to promoter. Pretreatment with COX-2- or p300-selective inhibitor melatonin-induced proliferation, whereas PGE2 treatment transfection reversed melatonin. Moreover, markedly phosphorylation PI3K, Akt, PRAS40, GSK-3 proteins, inactivating PI3K/Akt signaling pathway. PI3K- an Akt-selective Akt-specific siRNA blocked proliferation. Conversely, gene delivery constitutively active Akt effectively Furthermore, Apaf-1 expression, triggered cytochrome C release, stimulated caspase-3 caspase-9 activities cleavage, leading activation Apaf-1-dependent apoptotic Apaf-1-specific attenuated apoptosis. These results therefore indicate that inhibits induces cells vitro simultaneously suppressing COX-2/PGE2, p300/NF-κB, PI3K/Akt/signaling activating Apaf-1/caspase-dependent

Language: Английский

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Melatonin as Adjuvant Cancer Care With and Without Chemotherapy

Integrative Cancer Therapies, Journal Year: 2011, Volume and Issue: 11(4), P. 293 - 303

Published: Oct. 21, 2011

Background. Melatonin (MLT) is known to possess potent antioxidant, antiproliferative, immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer. The authors systematically reviewed effects conjunction with chemotherapy, radiotherapy, supportive care, palliative care on 1-year survival, complete response, partial stable disease, chemotherapy-associated toxicities. Methods. searched 7 databases: MEDLINE (1966-February 2010), AMED (1985-February Alt HealthWatch (1995-February CINAHL (1982-February Nursing Allied Health Collection: Basic Cochrane Database (2009), Chinese database CNKI (1979-February 2010). They included all trials randomized patients treatment, including or similar control group without MLT. Results. data from 21 clinical trials, which dealt solid tumors. pooled relative risk (RR) for mortality was 0.63 (95% confidence interval [CI] = 0.53-0.74; P < .001). Improved effect found disease RRs 2.33 CI 1.29-4.20), 1.90 (1.43-2.51), 1.51 (1.08-2.12), respectively. In combining adjuvant decreased (RR 0.60; 95% 0.54-0.67) improved outcomes disease; were 2.53 (1.36-4.71), 1.70 (1.37-2.12), 1.15 (1.00-1.33), these studies, also significantly reduced asthenia, leucopenia, nausea vomiting, hypotension, thrombocytopenia. Conclusion. benefit cancer who are receiving therapy, therapy by improving survival ameliorating side chemotherapy.

Language: Английский

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