Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 19
Published: Feb. 15, 2022
Cancer
is
one
of
the
greatest
causes
death
worldwide.
With
development
surgery,
radiotherapy,
and
medical
agents,
outcomes
cancer
patients
have
greatly
improved.
However,
underlying
mechanisms
are
not
yet
fully
understood.
Recently,
natural
products
been
proven
to
be
beneficial
for
various
conditions
played
important
roles
in
novel
therapies.
A
substantial
amount
evidence
indicates
that
bioactive
compounds
could
improve
via
pathways,
such
as
endoplasmic
reticulum
stress,
epigenetic
modification,
modulation
oxidative
stress.
Here,
we
review
current
treatment
summarize
this
pathological
process.
Journal of Medicinal Chemistry,
Journal Year:
2020,
Volume and Issue:
63(21), P. 12290 - 12358
Published: July 20, 2020
The
amide
functional
group
plays
a
key
role
in
the
composition
of
biomolecules,
including
many
clinically
approved
drugs.
Bioisosterism
is
widely
employed
rational
modification
lead
compounds,
being
used
to
increase
potency,
enhance
selectivity,
improve
pharmacokinetic
properties,
eliminate
toxicity,
and
acquire
novel
chemical
space
secure
intellectual
property.
introduction
bioisostere
leads
structural
changes
molecular
size,
shape,
electronic
distribution,
polarity,
pKa,
dipole
or
polarizability,
which
can
be
either
favorable
detrimental
biological
activity.
This
approach
has
opened
up
new
avenues
drug
design
development
resulting
more
efficient
candidates
introduced
onto
market
as
well
clinical
pipeline.
Herein,
we
review
strategic
decisions
selecting
an
(the
why),
synthetic
routes
each
how),
success
stories
implementation)
provide
comprehensive
overview
this
important
toolbox
for
medicinal
chemists.
Molecules,
Journal Year:
2018,
Volume and Issue:
23(3), P. 518 - 518
Published: Feb. 26, 2018
Melatonin
is
a
natural
indoleamine
produced
by
the
pineal
gland
that
has
many
functions,
including
regulation
of
circadian
rhythm.
Many
studies
have
reported
anticancer
effect
melatonin
against
myriad
cancer
types.
Cancer
hallmarks
include
sustained
proliferation,
evading
growth
suppressors,
metastasis,
replicative
immortality,
angiogenesis,
resisting
cell
death,
altered
cellular
energetics,
and
immune
evasion.
activity
mediated
interfering
with
various
hallmarks.
This
review
summarizes
role
in
each
hallmark.
The
discussed
this
should
serve
as
solid
foundation
for
researchers
physicians
to
support
basic
clinical
on
promising
agent.
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(11), P. 1088 - 1088
Published: Nov. 5, 2020
Melatonin,
an
indoleamine
hormone
produced
and
secreted
at
night
by
pinealocytes
extra-pineal
cells,
plays
important
role
in
timing
circadian
rhythms
(24-h
internal
clock)
regulating
the
sleep/wake
cycle
humans.
However,
recent
years
melatonin
has
gained
much
attention
mainly
because
of
its
demonstrated
powerful
lipophilic
antioxidant
free
radical
scavenging
action.
Melatonin
been
proven
to
be
twice
as
active
vitamin
E,
believed
most
effective
antioxidant.
Melatonin-induced
signal
transduction
through
receptors
promotes
expression
enzymes
well
inflammation-related
genes.
also
exerts
immunomodulatory
action
stimulation
high-affinity
expressed
immunocompetent
cells.
Here,
we
reviewed
efficacy,
safety
side
effects
supplementation
treating
oxidative
stress-
and/or
disorders,
such
obesity,
cardiovascular
diseases,
immune
infectious
cancer,
neurodegenerative
osteoporosis
infertility.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(9), P. 2506 - 2506
Published: April 25, 2021
Melatonin
is
a
pleotropic
molecule
with
numerous
biological
activities.
Epidemiological
and
experimental
studies
have
documented
that
melatonin
could
inhibit
different
types
of
cancer
in
vitro
vivo.
Results
showed
the
involvement
anticancer
mechanisms
including
apoptosis
induction,
cell
proliferation
inhibition,
reduction
tumor
growth
metastases,
side
effects
associated
chemotherapy
radiotherapy,
decreasing
drug
resistance
therapy,
augmentation
therapeutic
conventional
therapies.
Clinical
trials
revealed
an
effective
adjuvant
to
all
This
review
summarized
biosynthesis,
availability
from
natural
sources,
metabolism,
bioavailability,
melatonin,
its
use
clinical
trials,
pharmaceutical
formulation.
Studies
discussed
this
will
provide
solid
foundation
for
researchers
physicians
design
develop
new
therapies
treat
prevent
using
melatonin.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(18), P. 9996 - 9996
Published: Sept. 16, 2021
Melatonin
is
a
ubiquitous
indolamine,
largely
investigated
for
its
key
role
in
the
regulation
of
several
physiological
processes
both
animals
and
plants.
In
last
century,
it
was
reported
that
this
molecule
may
be
produced
high
concentrations
by
species
belonging
to
plant
kingdom
stored
specialized
tissues.
review,
main
information
related
chemistry
melatonin
metabolism
has
been
summarized.
Furthermore,
biosynthetic
pathway
characteristics
animal
cells
have
compared,
differences
between
two
systems
highlighted.
Additionally,
order
investigate
distribution
indolamine
kingdom,
cluster
analysis
performed
using
database
composed
47
previously
published
articles
reporting
content
different
families,
Finally,
potential
pharmacological
biostimulant
benefits
derived
from
administration
exogenous
on
or
plants
via
intake
dietary
supplements
application
formulation
discussed.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1238 - 1238
Published: Jan. 22, 2022
The
skin,
being
the
largest
organ
in
human
body,
is
exposed
to
environment
and
suffers
from
both
intrinsic
extrinsic
aging
factors.
skin
process
characterized
by
several
clinical
features
such
as
wrinkling,
loss
of
elasticity,
rough-textured
appearance.
This
complex
accompanied
with
phenotypic
functional
changes
cutaneous
immune
cells,
well
structural
disturbances
extracellular
matrix
components
collagens
elastin.
Because
health
considered
one
principal
factors
representing
overall
“well-being”
perception
“health”
humans,
anti-aging
strategies
have
recently
been
developed.
Thus,
while
fundamental
mechanisms
regarding
are
known,
new
substances
should
be
for
introduction
into
dermatological
treatments.
Herein,
we
describe
melatonin
its
metabolites
potential
“aging
neutralizers”.
Melatonin,
an
evolutionarily
ancient
derivative
serotonin
hormonal
properties,
main
neuroendocrine
secretory
product
pineal
gland.
It
regulates
circadian
rhythmicity
also
exerts
anti-oxidative,
anti-inflammatory,
immunomodulatory,
anti-tumor
capacities.
intention
this
review
summarize
within
aging,
research
advances
on
molecular
leading
these
changes,
impact
melatoninergic
anti-oxidative
system
controlled
metabolites,
targeting
prevention
or
reversal
aging.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(14), P. 4523 - 4523
Published: July 15, 2022
Cancer
has
been
a
serious
public
health
problem.
Berberine
is
famous
natural
compound
from
medicinal
herbs
and
shows
many
bioactivities,
such
as
antioxidant,
anti-inflammatory,
antidiabetic,
anti-obesity,
antimicrobial
activities.
In
addition,
berberine
anticancer
effects
on
variety
of
cancers,
breast,
lung,
gastric,
liver,
colorectal,
ovarian,
cervical,
prostate
cancers.
The
underlying
mechanisms
action
include
inhibiting
cancer
cell
proliferation,
suppressing
metastasis,
inducing
apoptosis,
activating
autophagy,
regulating
gut
microbiota,
improving
the
drugs.
This
paper
summarizes
effectiveness
different
cancers
highlights
action.
nanotechnologies
to
improve
bioavailability
are
included.
Moreover,
side
also
discussed.
helpful
for
prevention
treatment
using
berberine.
