Observation on prefrontal cortex activation in patients with Parkinson’s disease: a fNIRS study DOI Creative Commons
Yingqi Li, T. Hu, Yingpeng Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 30, 2025

Background Patients with Parkinson’s disease (PD) commonly experience difficulties when performing a second task while walking. The mechanisms underlying dual-task walking deficits remain poorly understood. In previous studies the tasks were often simplistic, typically comprising questions from standardized cognitive assessments. Additionally, existing fNIRS comparing PD patients and healthy controls have reported inconsistent findings, limiting our understanding of prefrontal cortex (PFC) contributions to cognitive-motor integration. Methods Forty-two older adults (15 men 27 women, age 59.97 ± 5.58 years) fifty-eight (25 33 61.07 7.56 years, Hoehn Yahr stage 1∼3) enrolled. protocol consisted three repetitions these conditions: stationary marching two-digit arithmetic calculating. Researchers used measure PFC activation changes in △HbO2 concentration during execution. Results Healthy demonstrated task-dependent modulation - selective (6/22 channels, p < 0.05) single-task conditions contrasted global engagement (22/22 under demands. contrast, showed widespread across all 22 channel regions both single dual ( 0.05). During switching, subjects experienced significant increases 15/22 0.05), paralleled by rises ΔHbO2 concentrations five 0.05; Cohen’s d ranging 0.43 0.82). Conversely, exhibited no difference > between 0.30). Conclusion Findings indicate that simple underengage resources individuals, whereas engage greater meet heightened owing disruptions cortico-basal ganglia-thalamocortical circuitry, exhibit “ceiling effect” activation: increased difficulty fails elicit proportional activation, likely because already overtax resources. This divergence neural adaptability underscores core differences integration individuals patients, providing basis for developing targeted interventions enhance efficiency.

Language: Английский

The age-related contribution of cognitive function to dual-task gait in middle-aged adults in Spain: observations from a population-based study DOI Creative Commons
Junhong Zhou, Gabriele Cattaneo, Wanting Yu

et al.

The Lancet Healthy Longevity, Journal Year: 2023, Volume and Issue: 4(3), P. e98 - e106

Published: March 1, 2023

Language: Английский

Citations

26
Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition DOI
Núbia Ribeiro da Conceição, Lílian Teresa Bucken Gobbi, Priscila Nóbrega‐Sousa

et al.

Neurorehabilitation and neural repair, Journal Year: 2021, Volume and Issue: 35(8), P. 717 - 728

Published: May 28, 2021

Background Since people with Parkinson disease (PD) rely on limited prefrontal executive resources for the control of gait, interventions targeting cortex (PFC) may help in managing PD-related gait impairments. Transcranial direct current stimulation (tDCS) can be used to modulate PFC excitability and improve cognitive functions gait. Objective We investigated effects adding anodal tDCS applied over a session aerobic exercise cognition, activity while walking PD. Methods A total 20 PD participated this randomized, double-blinded, sham-controlled crossover study. Participants attended two 30-minute sessions (cycling at moderate intensity) combined different conditions (active- or sham-tDCS), 1 week apart. The order was counterbalanced across sample. Anodal (2 mA minutes [active-tDCS] 10 s [sham-tDCS]) targeted most affected hemisphere. Spatiotemporal parameters, functions, were assessed before immediately after each session. Results Compared pre-assessment, participants decreased step time variability (effect size: −0.4), shortened simple choice reaction times sizes: −0.73 −0.57, respectively), increased stimulated hemisphere 0.54) only + active-tDCS. Conclusion addition led immediate positive variability, processing speed,

Language: Английский

Citations

41
Gait Impairment in Traumatic Brain Injury: A Systematic Review DOI Creative Commons

Anthony Dever,

Dylan Powell, Lisa Graham

et al.

Sensors, Journal Year: 2022, Volume and Issue: 22(4), P. 1480 - 1480

Published: Feb. 14, 2022

Introduction: Gait impairment occurs across the spectrum of traumatic brain injury (TBI); from mild (mTBI) to moderate (modTBI), severe (sevTBI). Recent evidence suggests that objective gait assessment may be a surrogate marker for neurological such as TBI. However, most optimal method is still not well understood due previous reliance on subjective approaches. The purpose this review was examine impairments Methods: PubMed, AMED, OVID and CINAHL databases were searched with search strategy containing key terms TBI gait. Original research articles reporting outcomes in adults (mTBI, modTBI, sevTBI) included. Results: 156 citations identified search, these, 13 studies met initial criteria included into review. findings reviewed suggest impaired mTBI, modTBI sevTBI (in acute chronic stages), but methodological limitations evident within all studies. Inertial measurement units used assess gait, single-task, dual-task obstacle crossing conditions used. No examined full differed their protocols. Recommendations future are provided. Conclusion: found regardless severity level sevTBI), (transparency reproducibility) limit clinical application. Further required establish standardised procedure fully determine comprehensive consistent

Language: Английский

Citations

35
Can transcranial direct current stimulation combined with interactive computerized cognitive training boost cognition and gait performance in older adults with mild cognitive impairment? a randomized controlled trial DOI Creative Commons
Chi Ieong Lau, Mu‐N Liu, Fang‐Yu Cheng

et al.

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 16, 2024

Abstract Background Older adults with Mild Cognitive Impairment (MCI) are often subject to cognitive and gait deficits. Interactive Computerized Training (ICCT) may improve function; however, the effect of such training on performance is limited. Transcranial Direct Current Stimulation (tDCS) improves cognition performance. It remains unclear whether combining tDCS ICCT produces an enhanced synergistic complex relative alone. This study aimed compare effects combined in older MCI. Method Twenty-one MCI were randomly assigned groups receiving either anodal ( + ) or sham ). Participants played Nintendo Switch games for 40 min per session, simultaneously over left dorsolateral prefrontal cortex first 20 min. assessments performed before after 15 sessions. Results The global cognition, executive function, working-memory scores improved both groups, but there no significant interaction outcomes. Additionally, group × time interactions indicated that significantly dual-task terms speed p = 0.045), variability 0.016), cost 0.039) compared ICCT. Conclusion was not superior alone; it had a impact Administering as adjunct thus provide additional benefits Trial registration trial registered at http://www.clinicaltrials.in.th/ (TCTR 20,220,328,009).

Language: Английский

Citations

7
Prefrontal Cortex Activity During Gait in People With Persistent Symptoms After Concussion DOI
Douglas N. Martini, Martina Mancini, Prokopios Antonellis

et al.

Neurorehabilitation and neural repair, Journal Year: 2024, Volume and Issue: 38(5), P. 364 - 372

Published: March 20, 2024

Background Concussions result in transient symptoms stemming from a cortical metabolic energy crisis. Though this crisis typically resolves month, can persist for years. The symptomatic period is associated with gait dysfunction, the underpinnings of which are poorly understood. Quantifying prefrontal cortex (PFC) activity during may provide insight into post-concussion dysfunction. purpose study was to explore effects persisting concussion on PFC gait. We hypothesized that adults would have greater than controls. Within concussed group, we worse relate increased gait, and characteristics. Methods Neurobehavior Symptom Inventory (NSI) characterized symptoms. Functional near-infrared spectroscopy quantified (relative concentration changes oxygenated hemoglobin [HbO 2 ]) 14 people 25 Gait assessed using six inertial sensors group. Results Average NSI total score 26.4 (13.2). HbO significantly higher ( P = .007) group (0.058 [0.108]) compared control (−0.016 [0.057]). correlated symptom (ρ .62; .02), sagittal range motion r .79; .001), stride time variability −.54; .046). Conclusion These data suggest relates severity some characteristics persistent Identifying neurophysiological deficits expands our knowledge motor behavior

Language: Английский

Citations

6
Changes in Prefrontal Cortical Activity During Walking and Cognitive Functions Among Patients With Parkinson's Disease DOI Creative Commons
Maud Ranchet, Isabelle Hoang,

Maxime Cheminon

et al.

Frontiers in Neurology, Journal Year: 2020, Volume and Issue: 11

Published: Dec. 10, 2020

Background: Walking becomes more and degraded as Parkinson's Disease (PD) progresses. Previous research examined factors contributing to this deterioration. Among them, changes in brain cortical activity during walking have been less studied clinical population. Objectives: This study aimed to: (1) investigate dorsolateral prefrontal cortex (DLPFC) activation usual dual-task conditions patients with PD; (2) examine the association between behavioral/cognitive outcomes; (3) explore which best predict increased of DLPFC walking. Methods: Eighteen early stage PD 18 controls performed 4 conditions: standing while subtracting, walking, counting forward, (4) subtracting. Cortical DLPFC, assessed by oxy-hemoglobin (ΔHbO 2 ) deoxy-hemoglobin (ΔHbR), was measured using functional near infrared spectroscopy (fNIRS). Gait performance recorded wearables sensors. Cognition also neuropsychological tests, including Trail Making Test (TMT). Results: higher compared both subtracting conditions. Patients had impaired only task. Moderate-to-strong correlations ΔHbO coefficients variation all gait parameters were found for forward Part-B TMT predicted 21% variance after adjustment group status. Conclusions: The suggests a potential compensation executive deficits. Understanding may implications rehabilitation PD.

Language: Английский

Citations

44
Task matters: an investigation on the effect of different secondary tasks on dual-task gait in older adults DOI Creative Commons
Hui‐Ting Goh,

Miranda Pearce,

Asha Vas

et al.

BMC Geriatrics, Journal Year: 2021, Volume and Issue: 21(1)

Published: Sept. 25, 2021

Dual-task gait performance declines as humans age, leading to increased fall risk among older adults. It is unclear whether different secondary cognitive tasks mediate age-related decline in dual-task gait. This study aimed examine how type and difficulty level of the differentially affect adults.Twenty young twenty adults participated this single-session study. We employed four types each consisted two levels, yielding eight conditions. The conditions included walking 1) counting backward by 3 s or 7 s; 2) remembering a 5-item 7-item lists; 3) responding simple choice reaction time tasks; 4) generating words from single alternated categories. Gait speed task under single- were used compute cost (DTC, %) with greater DTC indicating worse performance.A significant three-way interaction was found for (p = .04). Increased significantly .01) but not .90). In contrast, .03) .85). Both groups responded similarly other tasks.Older demonstrated response challenges than Aging might have impacts on various domains result distinctive interference patterns.

Language: Английский

Citations

36
Targeted tDCS Mitigates Dual‐Task Costs to Gait and Balance in Older Adults DOI
Junhong Zhou, Brad Manor, Wanting Yu

et al.

Annals of Neurology, Journal Year: 2021, Volume and Issue: 90(3), P. 428 - 439

Published: July 3, 2021

Among older adults, the ability to stand or walk while performing cognitive tasks (ie, dual-tasking) requires coordinated activation of several brain networks. In this multicenter, double-blinded, randomized, and sham-controlled study, we examined effects modulating excitability left dorsolateral prefrontal cortex (L-DLPFC) primary sensorimotor (SM1) on dual-task performance "costs" standing walking.Fifty-seven adults without overt illness disease completed 4 separate study visits during which they received 20 minutes transcranial direct current stimulation (tDCS) optimized facilitate L-DLPFC SM1 simultaneously, each region separately, neither (sham). Before immediately after stimulation, participants a paradigm in were asked with concurrent serial-subtraction task.tDCS simultaneously targeting SM1, as well tDCS alone, mitigated costs walking greater extent than alone sham (p < 0.02). Blinding efficacy was excellent participant subjective belief type (real sham) did not contribute observed functional benefits tDCS.These results demonstrate that decrements may be amenable change implicate L-DPFC modifiable component control system enables walking. used improve resilience under challenging conditions, potentially enhancing everyday functioning reducing fall risks. ANN NEUROL 2021;90:428-439.

Language: Английский

Citations

35
Paradoxical improvement of cognitive control in older adults under dual-task walking conditions is associated with more flexible reallocation of neural resources: A Mobile Brain-Body Imaging (MoBI) study DOI Creative Commons
Eleni Patelaki, John J. Foxe, Emma P. Mantel

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 273, P. 120098 - 120098

Published: April 8, 2023

Combining walking with a demanding cognitive task is traditionally expected to elicit decrements in gait and/or performance. However, it was recently shown that, cohort of young adults, most participants improved performance when added Go/NoGo response inhibition task. The present study aims extend these previous findings an older adult cohort, investigate whether this improvement dual-tasking observed healthy adults. Mobile Brain/Body Imaging (MoBI) used record electroencephalographic (EEG) activity, three-dimensional (3D) kinematics and behavioral responses the task, during sitting or on treadmill, 34 adults 37 Increased accuracy walking, independent age, found correlate slower stimuli (r = 0.44) walking-related EEG amplitude modulations over frontocentral regions 0.47) sensory gating (N1) conflict monitoring (N2) stages inhibition, left-lateralized prefrontal stage inhibitory control implementation (P3). These neural activity changes are related component they were interpreted as signatures walking. On other hand, aging, treadmill speeds -0.68) attenuation left-dominant frontal -0.44) parietooccipital 0.48) N2 stage, centroparietal P3 stage. motor aging. Older whose 'paradoxically' manifested both suggesting that their flexibility reallocating resources while might be maintained for but not component. distinct aging behavior can potentially identify 'super-agers', individuals at risk decline due neurodegenerative disease.

Language: Английский

Citations

13
Prefrontal cortical activity during uneven terrain walking in younger and older adults DOI Creative Commons
Jungyun Hwang, Chang Liu, Steven P. Winesett

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 3, 2024

Introduction Walking in complex environments increases the cognitive demand of locomotor control; however, our understanding neural mechanisms contributing to walking on uneven terrain is limited. We used a novel method for altering unevenness treadmill investigate association between and cortical activity prefrontal cortex, region known be involved various functions. Methods Prefrontal was measured with functional near infrared spectroscopy while participants walked custom-made surface across four different terrains: flat, low, medium, high levels unevenness. The assessments were conducted younger adults, older adults better mobility function worse function. Mobility assessed using Short Physical Performance Battery. primary hypothesis that increasing would result greater activation all groups. Secondary hypotheses heightened observed groups relative group, plateau at higher function, as predicted by Compensation Related Utilization Neural Circuits Hypothesis. Results results revealed significant main effect terrain, indicating increase during A group compared pooled terrains, but there no difference adults. Contrary hypothesis, displayed sustained other did not, suggestive compensation. Additional findings task-related lateralized right hemisphere bilateral Discussion These support flat surface, surfaces control resources activation.

Language: Английский

Citations

5