Fish Scale Collagen Peptides Protect against CoCl2/TNF‐α‐Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF‐κB Pathways in HaCaT Cells DOI Creative Commons
Fazli Subhan, Hae Yeong Kang,

Ye-Seon Lim

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2017, Volume and Issue: 2017(1)

Published: Jan. 1, 2017

Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses human HaCaT keratinocyte cells. Our is first to report FSCP increase cell viability ameliorate injury cells through mechanisms mediated by downregulation of key proinflammatory cytokines, namely, TNF-α, IL-1β, IL-8, iNOS. also prevent apoptosis repressing Bax expression, caspase-3 activity, cytochrome c release upregulating Bcl-2 protein levels CoCl2- TNF-α-stimulated In addition, inhibitory effects on induction cytokine expression were found be suppression ROS, MAPK (p38/MAPK, ERK, JNK), NF-κB signaling pathways. Taken together, our data suggest are useful as immunomodulatory agents immune-mediated skin diseases. Furthermore, results provide new insights into potential therapeutic use prevention treatment various oxidative- stress-related injuries.

Language: Английский

Anti-Inflammatory Action and Mechanisms of Resveratrol DOI Creative Commons
Tiantian Meng, Dingfu Xiao,

Arowolo Muhammed

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(1), P. 229 - 229

Published: Jan. 5, 2021

Resveratrol (3,4',5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This is well-absorbed rapidly extensively metabolized in the body. Inflammation an adaptive response, which could be triggered by various danger signals, such as invasion microorganisms or tissue injury. In this review, anti-inflammatory activity mechanism of resveratrol modulates inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms immunomodulatory function both vivo vitro. The data acquired from those discussed.

Language: Английский

Citations

454
Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems DOI Creative Commons
Bechan Sharma, Shweta Singh, Nikhat J. Siddiqi

et al.

BioMed Research International, Journal Year: 2014, Volume and Issue: 2014, P. 1 - 26

Published: Jan. 1, 2014

Several workers have extensively worked out the metal induced toxicity and reported toxic carcinogenic effects of metals in human animals. It is well known that these play a crucial role facilitating normal biological functions cells as well. One major mechanisms associated with heavy has been attributed to generation reactive oxygen nitrogen species, which develops imbalance between prooxidant elements antioxidants (reducing elements) body. In this process, shift former termed oxidative stress. The stress mediated involves damage primarily liver (hepatotoxicity), central nervous system (neurotoxicity), DNA (genotoxicity), kidney (nephrotoxicity) animals humans. Heavy are impact signaling cascade factors leading apoptosis. present review illustrates an account current knowledge about (mainly arsenic, lead, mercury, cadmium) possible remedies metal(s) through natural/synthetic antioxidants, may render their by reducing concentration metal(s). This paper concerns clinicopathological biomedical implications management mammals.

Language: Английский

Citations

405
Photodynamic Therapy—Current Limitations and Novel Approaches DOI Creative Commons
Gürcan Günaydın, Mustafa Emre Gedik, Seylan Ayan

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: June 10, 2021

Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via excitation a photosensitizer, so that target tumor cells can be destroyed. PDT applied in settings several malignant diseases. In fact, earliest preclinical applications date back to 1900’s. Dougherty reported treatment skin tumors by 1978. Several further studies around 1980 demonstrated effectiveness PDT. Thus, technique has attracted attention numerous researchers since then. Hematoporphyrin derivative received FDA approval as clinical application 1995. We have indeed witnessed considerable progress field over last century. Given fact favorable adverse event profile and enhance anti-tumor immune responses well demonstrating minimally invasive characteristics, it is disappointing not broadly utilized setting for and/or non-malignant issues still hinder development PDT, such those related with light, tissue oxygenation inherent properties photosensitizers. Various photosensitizers been designed/synthesized order overcome limitations. this Review, we provide general overview mechanisms action terms cancer, including effects system vasculature cell destruction. will also briefly mention The current limitations utilization cancer reviewed, identifying problems associated design/synthesis light might pave way more effective approaches. Furthermore, novel promising approaches improve outcome selectivity, bioengineering, subcellular/organelle targeting, etc. discussed detail, potential pioneering exceptional aim reveal full translation are undoubtedly exciting. A better understanding concepts ( e.g. enhanced, two-stage, fractional PDT) most likely prove very useful pursuing improving strategies.

Language: Английский

Citations

391
Targeting RTK Signaling Pathways in Cancer DOI
Tarik Regad

Cancers, Journal Year: 2015, Volume and Issue: 7(3), P. 1758 - 1784

Published: Sept. 3, 2015

The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in regulation of proliferation, differentiation survival. induction these depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive aberrant activations components those result increased survival metastasis. For instance, mutations affecting RTKs, Ras, B-Raf, PI3K AKT common perpetuating malignancy several types cancers from different tissue origins. Therefore, signaling became prime targets for cancer therapy. This review aims to provide an overview about most frequently encountered mutations, pathogenesis results such known therapeutic strategies developed counteract their functions.

Language: Английский

Citations

350
The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke DOI
Jing Sun, Guangxian Nan

Journal of Molecular Neuroscience, Journal Year: 2016, Volume and Issue: 59(1), P. 90 - 98

Published: Feb. 3, 2016

Language: Английский

Citations

203
Targeted protein degradation: A promise for undruggable proteins DOI Creative Commons
Kusal T. G. Samarasinghe, Craig M. Crews

Cell chemical biology, Journal Year: 2021, Volume and Issue: 28(7), P. 934 - 951

Published: May 17, 2021

Language: Английский

Citations

187
Metagenomic deep sequencing reveals association of microbiome signature with functional biases in bovine mastitis DOI Creative Commons
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement

et al.

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: Sept. 19, 2019

Abstract Milk microbiomes significantly influence the pathophysiology of bovine mastitis. To assess association between microbiome diversity and mastitis, we compared clinical mastitis (CM, n = 14) healthy (H, 7) milk samples through deep whole metagenome sequencing (WMS). A total 483.38 million reads generated from both metagenomes were analyzed PathoScope (PS) MG-RAST (MR), mapped to 380 bacterial, 56 archaeal, 39 viral genomes. We observed distinct shifts differences in abundance CM H phyla Proteobacteria , Bacteroidetes Firmicutes Actinobacteria with an inclusion 68.04% previously unreported and/or opportunistic strains milk. PS identified 363 146 bacterial respectively, MR detected 356 251 genera respectively. Of taxa, 29.51% 63.80% shared metagenomes. Additionally, 14 archaeal found be solely associated CM. Functional annotation metagenomic sequences several metabolic pathways related colonization, proliferation, chemotaxis invasion, immune-diseases, oxidative stress, regulation cell signaling, phage prophases, antibiotic heavy metal resistance that might Our WMS study provides conclusive data on its role udder health.

Language: Английский

Citations

160
Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma DOI Open Access

Lesley Jia Wei Pua,

Chun‐Wai Mai, Felicia Fei‐Lei Chung

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1108 - 1108

Published: Jan. 20, 2022

c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK) family members integrate signals that affect proliferation, differentiation, survival, migration in a cell context- type-specific way. JNK MAPK activities are found upregulated nasopharyngeal carcinoma (NPC). Studies have shown activation of signaling can promote NPC oncogenesis by mechanisms within the cancer cells interactions with tumor microenvironment. They regulate multiple transcription contribute to tumor-promoting processes, ranging from proliferation apoptosis, inflammation, metastasis, angiogenesis. Current literature suggests may exert pro-tumorigenic functions NPC, though underlying not well documented yet be fully explored. Here, we aim provide narrative review pathways human cancers primary focus on NPC. We also discuss potential therapeutic agents could used target along perspectives for future works. inspire studies further delineating which might offer important insights better strategies diagnosis, prognosis, treatment decision-making patients.

Language: Английский

Citations

112
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness DOI Creative Commons
Yize Li, T. Mamie Lih, Saravana M. Dhanasekaran

et al.

Cancer Cell, Journal Year: 2022, Volume and Issue: 41(1), P. 139 - 163.e17

Published: Dec. 22, 2022

Clear cell renal carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- intratumoral heterogeneity (ITH) results in varying prognosis treatment outcomes. To obtain the comprehensive profile ccRCC, we perform integrative histopathologic, proteogenomic, metabolomic analyses on 305 ccRCC tumor segments 166 paired adjacent normal tissues from 213 cases. Combining histologic molecular profiles reveals ITH 90% ccRCCs, with 50% demonstrating immune signature heterogeneity. High grade, along BAP1 mutation, genome instability, increased hypermethylation, a specific protein glycosylation define high-risk disease subset, where UCHL1 expression displays prognostic value. Single-nuclei RNA sequencing adverse sarcomatoid rhabdoid phenotypes uncover gene signatures potential insights into evolution. In vitro line studies confirm inhibiting identified phosphoproteome targets. This study molecularly stratifies aggressive histopathologic subtypes that may inform more effective strategies.

Language: Английский

Citations

109
E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers DOI
Hong‐Beom Park, Kwang‐Hyun Baek

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2022, Volume and Issue: 1877(3), P. 188736 - 188736

Published: May 1, 2022

Language: Английский

Citations

101