Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 14, 2022

Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, beverages like fruit juices, tea, coffee wine. In recent years, dietary have gained significant interest among researchers due to their potential chemopreventive/protective functions the maintenance of human health diseases. It is believed that polyphenols/flavonoids exert powerful antioxidant action for protection against reactive oxygen species (ROS)/cellular oxidative stress (OS) towards prevention OS-related pathological conditions or Pre-clinical clinical evidence strongly suggest long term consumption diets rich offer development various chronic diseases such as neurodegenerative diseases, cardiovascular (CVDs), cancer, diabetes, inflammatory disorders infectious illness. Increased intake foods containing (for example, quercetin, epigallocatechin-3-gallate, resveratrol, cyanidin etc.) has been claimed reduce extent a majority cellular damage, DNA tissue inflammations, viral/bacterial infections, suggested activity plays pivotal role OS-induced this narrative review, biological/pharmacological significance and/or major cancers, CVDs, diabetes mellitus, delineated. This review specifically focuses current understanding on sources protective effects mechanisms

Language: Английский

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Resveratrol (RV): A pharmacological review and call for further research

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 143, P. 112164 - 112164

Published: Oct. 4, 2021

Resveratrol (RV) is a well-known polyphenolic compound in various plants, including grape, peanut, and berry fruits, which quite famous for its association with several health benefits such as anti-obesity, cardioprotective neuroprotective, antitumor, antidiabetic, antioxidants, anti-age effects, glucose metabolism. Significantly, promising therapeutic properties have been reported cancer, neurodegeneration, atherosclerosis are regulated by synergistic pathways that control oxidative stress, cell death, inflammation. Similarly, RV possesses strong anti-adipogenic effect inhibiting fat accumulation processes activating lipolytic pathways, exhibiting their effects platelet aggregation. The also shows significant antibacterial against food-borne pathogens (Listeria, Campylobacter, Staphylococcus aureus, E. coli) an electron transport chain (ETC) F0F1-ATPase, decreases the production of cellular energy leads to spread pathogens. After collecting analyzing scientific literature, it may be concluded well tolerated favorably affects cardiovascular, neurological, diabetic disorders. As such, possible can considered best nutritional additive complementary drug, especially candidate. Therefore, this review would increase knowledge about blend inspire researchers around world consider pharmaceutical drug combat future crises inhumane diseases. In future, article will aware discoveries potential natural nutraceuticals drugs medicine.

Language: Английский

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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Molecules, Journal Year: 2021, Volume and Issue: 26(4), P. 1109 - 1109

Published: Feb. 19, 2021

Despite the recent advances in field of chemically synthetized pharmaceutical agents, nature remains main supplier bioactive molecules. The research natural products is a valuable approach for discovery and development novel biologically active compounds possessing unique structures mechanisms action. Although their use belongs to traditional treatment regimes, plant-derived still cover large portion current-day agents. Their medical importance well recognized oncology, especially as an alternative limitations conventional chemotherapy (severe side effects inefficacy due occurrence multi-drug resistance). This review offers comprehensive perspective first blockbuster chemotherapeutic agents origin's (e.g. taxol, vincristine, doxorubicin) mechanism action using 3D representation. In addition portrayed step-by-step evolution from preclinical clinical evaluation most recently studied with potent antitumor activity resveratrol, curcumin, betulinic acid, etc.) terms anticancer possible indications or chemopreventive sensitizers. Finally, this describes several efficient platforms encapsulation targeted delivery cancer treatment.

Language: Английский

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Polyphenols: From Theory to Practice

Foods, Journal Year: 2021, Volume and Issue: 10(11), P. 2595 - 2595

Published: Oct. 27, 2021

The importance of polyphenols in human health is well known; these compounds are common foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, different factors that modulate biological activity less known. Conceptualization work: In this review we took into account about 200 relevant recent papers on following topics: "polyphenols bioavailability", matrix effect", "food "polyphenols-cytochromes interaction", after having reviewed updated information chemical classification main properties polyphenols, antioxidant, anti-radical anti-inflammatory activity, together with tricky link between vitro tests clinical trials.

Language: Английский

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Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 22, 2022

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, nervous system. Excessive complications are closely related prognosis of RA patients even lead increased mortality. This article summarizes serious RA, focusing on its incidence, pathogenesis, clinical features, treatment methods, aiming provide reference for clinicians better manage RA.

Language: Английский

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The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 95 - 95

Published: Dec. 21, 2022

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation the immune system. This involves imbalance between pro-inflammatory versus anti-inflammatory mediators. These mediators include various cytokines and chemokines; defined subsets T helper/T regulatory cells, M1/M2 macrophages, activating/tolerogenic dendritic antibody-producing/regulatory B cells. Despite availability many anti-inflammatory/immunomodulatory drugs, severe adverse reactions associated with their long-term use often high costs impediments in effectively controlling disease process. Accordingly, suitable alternatives being sought for these conventional drugs. Natural products offer promising adjuncts/alternatives this regard. The specific compounds isolated from dietary/medicinal plant extracts have permitted rigorous studies on disease-modulating activities mechanisms involved therein. Here, we describe basic characteristics, action, preventive/therapeutic applications 5 well-characterized natural product (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, Triptolide). been tested extensively animal models autoimmunity as well limited clinical trials patients having corresponding diseases. We focused our description predominantly cell-mediated such rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, ulcerative colitis, psoriasis.

Language: Английский

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A cellulose nanofibril-reinforced hydrogel with robust mechanical, self-healing, pH-responsive and antibacterial characteristics for wound dressing applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 6, 2022

Abstract Background Bacterial infection in wounds has become a major threat to human life and health. With the growth use of synthetic antibiotics elevated evolution drug resistant bacteria body cells requires development novel wound curing strategies. Herein, pH-responsive hydrogel (RPC/PB) was fabricated using poly(vinyl alcohol)-borax (PB) natural antibiotic resveratrol grafted cellulose nanofibrils (RPC) for bacterial-infected management. Results In this matrix, RPC conjugate interpenetrated PB network form semi-interpenetrating that exhibited robust mechanical properties (fracture strength 149.6 kPa), high self-healing efficiency (> 90%), excellent adhesion performance (tissue shear stress 54.2 kPa). Interestingly, induced RPC/PB showed release behavior, cumulative amount pH 5.4 2.33 times than 7.4, which adapted well acidic microenvironment. Additionally, biocompatibility antioxidant effect. Moreover, vitro vivo results revealed such had antibacterial, skin tissue regeneration closure capabilities. Conclusion Therefore, generated could be an dressing bacteria-infected healing.

Language: Английский

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Recent Advances in Natural Polyphenol Research

Molecules, Journal Year: 2022, Volume and Issue: 27(24), P. 8777 - 8777

Published: Dec. 11, 2022

Polyphenols are secondary metabolites produced by plants, which contribute to the plant’s defense against abiotic stress conditions (e.g., UV radiation and precipitation), aggression of herbivores, plant pathogens. Epidemiological studies suggest that long-term consumption polyphenols protects cardiovascular disease, cancer, osteoporosis, diabetes, neurodegenerative diseases. Their structural diversity has fascinated confronted analytical chemists on how carry out unambiguous identification, exhaustive recovery from plants organic waste, define their nutritional biological potential. The food, cosmetic, pharmaceutical industries employ fruits vegetables produce additives, additional foods, supplements. In some cases, nanocarriers have been used protect during food processing, solve issues related low water solubility, transport them site action, improve bioavailability. This review summarizes structure-bioactivity relationships, processing parameters impact polyphenol stability bioavailability, research progress in nanocarrier delivery, most innovative methodologies for agri-waste materials.

Language: Английский

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The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 2, 2023

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms IS. In particular, early proinflammatory response resulting from overactivation resident microglia infiltration circulating monocytes macrophages brain after cerebral ischemia leads to secondary injury. Microglia are innate immune cells that constantly monitor microenvironment under normal conditions. Once occurs, activated produce dual effects neurotoxicity neuroprotection, balance two determines fate damaged neurons. The activation defined as classical (M1 type) or alternative (M2 type). M1 type secrete pro-inflammatory cytokines neurotoxic mediators exacerbate neuronal damage, while M2 promote a repairing anti-inflammatory response. Fine regulation M1/M2 microglial minimize damage maximize protection has therapeutic value. This review focuses on interaction between other involved IS phenotypic characteristics, mechanism natural plant components regulating IS, providing novel candidate drugs for drug development.

Language: Английский

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Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

Pharmacological Research, Journal Year: 2023, Volume and Issue: 193, P. 106812 - 106812

Published: June 2, 2023

Polyphenols, also known as phenolic compounds, are chemical substances containing aromatic rings well at least two hydroxyl groups. Natural compounds exist widely in plants, which protect plants from ultraviolet radiation and other insults. Phenolic have superior pharmacological nutritional properties (antimicrobial, antibacterial, antiviral, anti-sclerosis, antioxidant, anti-inflammatory activities), been paid more attention by the scientific community. Phenols can key cellular components reactive free radical damage, is mainly due to their property activate antioxidant enzymes alleviate oxidative stress inflammation. It inhibit or isolate oxygen species transfer electrons radicals, thereby avoiding cell damage. has a regulatory role glucose metabolism, promising prospect prevention intervention of diabetes. prevents cardiovascular disease regulating blood pressure lipids. Polyphenols proliferation affecting Erk1/2, CDK, PI3K/Akt signaling pathways. function enhancers intrinsic defense systems, including superoxide dismutase (SOD) glutathione peroxidase (GPX). Simultaneously, they modulate multiple proteins transcription factors, making them candidates investigation anti-cancer medications. This review focuses on aspects substances, natural origins, production process, disinfection activity, functions, effects different tumors.

Language: Английский

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