Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes DOI Creative Commons
Qingyuan Yu, Yanan Xiao, Mengqi Guan

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 5, 2024

Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, various other contributing factors. The complex interplay of cartilage damage, loss, impaired repair mechanisms remains critical formidable aspect OA pathogenesis. At the genetic level, multiple genes have been implicated in modulation chondrocyte metabolism, displaying both promotive inhibitory roles. Recent research has increasingly focused on influence non-coding RNAs regulation distinct cell types within bone tissue OA. In particular, an expanding body evidence highlights regulatory roles microRNAs chondrocytes. This review aims to consolidate most relevant associated with chondrocytes, as identified recent studies, elucidate their involvement processes ferroptosis. Furthermore, this study explores interactions between long (lncRNAs) circular (circRNAs) OA, emphasis microRNA-mediated mechanisms. Finally, gaps current are identified, offering strategic insights advance understanding pathophysiology guide therapeutic developments field.

Language: Английский

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes DOI Creative Commons
Qingyuan Yu, Yanan Xiao, Mengqi Guan

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 5, 2024

Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, various other contributing factors. The complex interplay of cartilage damage, loss, impaired repair mechanisms remains critical formidable aspect OA pathogenesis. At the genetic level, multiple genes have been implicated in modulation chondrocyte metabolism, displaying both promotive inhibitory roles. Recent research has increasingly focused on influence non-coding RNAs regulation distinct cell types within bone tissue OA. In particular, an expanding body evidence highlights regulatory roles microRNAs chondrocytes. This review aims to consolidate most relevant associated with chondrocytes, as identified recent studies, elucidate their involvement processes ferroptosis. Furthermore, this study explores interactions between long (lncRNAs) circular (circRNAs) OA, emphasis microRNA-mediated mechanisms. Finally, gaps current are identified, offering strategic insights advance understanding pathophysiology guide therapeutic developments field.

Language: Английский

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