General Clinico-Pathological Characteristics in Glioblastomas in Correlation with p53 and Ki67 DOI Creative Commons
Tamás-Csaba Sipos, Attila Kövecsi,

Șușu Ovidiu-Ioan

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(11), P. 1918 - 1918

Published: Oct. 30, 2023

Introduction: A glioblastoma is an intra-axial brain tumour of glial origin that belongs to the category diffuse gliomas and most common malignant neoplasia central nervous system. The rate survival at 5 years, from moment diagnosis, not higher than 10%. Materials methods: In this retrospective study, fifty-four patients diagnosed with glioblastoma, Pathology Department County Emergency Clinical Hospital Târgu Mureș, between 2014 2017 were included. We studied clinico-pathological data (age, gender, location, laterality) and, respectively, immunoexpression p53, Ki67, ATRX, IDH-1 proteins. Results: observed a statistically significant association laterality according age groups, localization on right side being more frequent in group below 65 years age, while involvement left hemisphere was prevalent those over years. Out total 54 cases, 87.04% found be primary glioblastomas; 70% cases ATRX immunopositive; almost 80% glioblastomas had wild-type p53 profile; 35% have Ki67 index greater 20%. gender mutation found; female immunopositive 92% cases. Almost both wild-type, we presence mutations only 3.7% Approximately 83% positive, all mutant negative. Conclusions: Glioblastomas still represent multidisciplinary challenge considering their reserved prognosis. described characteristics IHC marker expression profiles, highlighting variety percentage ranges secondary glioblastomas. Given small number further prospective studies larger cohorts are needed future evaluate role these immunohistochemical markers as prognostic factors for or recurrence.

Language: Английский

Glioblastoma’s Infrequent Locations and Synchronous Tumors DOI Creative Commons

Asem A. Muhsen,

Baha’eddin A. Muhsen

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Glioblastoma (GBM) is an exceedingly aggressive Grade IV astrocytoma and the most prevalent primary malignant brain tumor in adults, representing 45–50% of all gliomas. In our chapter, we have highlighted rare locations GBM, occurrence multiple its coexistence, alongside other cerebral neoplasms such as meningioma. While mostly situated hemispheres, glioblastomas can also arise atypical brainstem, thalamus, basal ganglia, corpus callosum, cerebellum, spinal cord. Multiple GBMs were identified 11.7% cases. Meningiomas are common benign tumors that coexist with collision tumors. This link may just be a coincidence or sign related pathogenesis. Further molecular biological studies necessary to confirm existence shared mechanisms genetic determinants.

Language: Английский

Citations

0
The 2021 World Health Organization Central Nervous System Tumor Classification: The Spectrum of Diffuse Gliomas DOI Creative Commons
Racine Gue, Dhairya A. Lakhani

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1349 - 1349

Published: June 18, 2024

The 2021 edition of the World Health Organization (WHO) classification central nervous system tumors introduces significant revisions across various tumor types. These updates, encompassing changes in diagnostic techniques, genomic integration, terminology, and grading, are crucial for radiologists, who play a critical role interpreting brain imaging. Such impact diagnosis management nearly all categories, including reclassification, addition, removal specific entities. Given their pivotal patient care, radiologists must remain conversant with these to effectively contribute multidisciplinary boards collaborate peers neuro-oncology, neurosurgery, radiation oncology, neuropathology. This knowledge is essential not only accurate staging, but also understanding molecular genetic underpinnings tumors, which can influence treatment decisions prognostication. review, therefore, focuses on most pertinent updates concerning adult diffuse gliomas, highlighting aspects relevant radiological practice. Emphasis placed implications new information behavior imaging findings, providing necessary tools stay abreast advancements field. comprehensive overview aims enhance radiologist’s ability integrate WHO criteria into everyday practice, ultimately improving outcomes through informed precise assessments.

Language: Английский

Citations

2
Efficacy of combined tumor irradiation and KCa3.1-targeting with TRAM-34 in a syngeneic glioma mouse model DOI Creative Commons
Nicolai Stransky, Katrin Ganser, Leticia Quintanilla‐Martínez

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 23, 2023

The intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in syngeneic, immune-competent orthotopic SMA-560/VM/Dk glioma mouse model. Whereas neither nor treatment alone meaningfully prolonged survival animals, combination significantly mice. We found an irradiation-induced hyperinvasion cells into brain, which was inhibited by concomitant Interestingly, did radiosensitize impair SMA-560's intrinsic migratory capacities vitro. Exploratory findings hint at increased TGF-β1 signaling after irradiation. On top, we marginal upregulation MMP9 mRNA, TRAM-34. Last, infiltration CD3+, CD8+ or FoxP3+ T not impacted either targeting no evidence adverse events conclude that is efficacious this preclinical

Language: Английский

Citations

6
In Situ Light-Source Delivery During 5-Aminulevulinic Acid-Guided High-Grade Glioma Resection: Spatial, Functional and Oncological Informed Surgery DOI Creative Commons
José Pedro Lavrador, Francesco Marchi,

Ali Elhag

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2748 - 2748

Published: Nov. 30, 2024

Background/Objectives: 5-aminulevulinic acid (5-ALA)-guided surgery for high-grade gliomas remains a challenge in neuro-oncological surgery. Inconsistent fluorescence visualisation, subjective quantification and false negatives due to blood, haemostatic agents or optical impediments from the external light source are some of limitations present technology. Methods: The preliminary results this single-centre retrospective study presented first 35 patients operated upon with novel Nico Myriad Spectra System©. microdebrider (Myriad) an additional situ system (Spectra) can alternately provide white blue (405 nm) within 15 mm tissue surface enhance morphology anatomical structures pathological tissues. Results: A total were new Eight (22.85%) underwent tubular retractor-assisted minimally invasive parafascicular (tr-MIPS). majority had (68.57%). Fluorescence was identified 30 cases (85.71%), residual 11 (36.66%). main applications better white–blue alternation visualisation during tr-MIPS, increase extent resection at border cavity, identification satellite lesions multifocal pathology, differentiation between radionecrosis tumour recurrence redo demarcation normal ependyma versus tumours infiltrating subventricular zone. Conclusions: This proof-of-concept confirms that light-source delivery technology integrated usual intraoperative armamentarium provides spatially, functionally oncologically informed framework glioblastoma It allows enhancement tissues, increasing and, possibly, prognosis gliomas.

Language: Английский

Citations

1
General Clinico-Pathological Characteristics in Glioblastomas in Correlation with p53 and Ki67 DOI Creative Commons
Tamás-Csaba Sipos, Attila Kövecsi,

Șușu Ovidiu-Ioan

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(11), P. 1918 - 1918

Published: Oct. 30, 2023

Introduction: A glioblastoma is an intra-axial brain tumour of glial origin that belongs to the category diffuse gliomas and most common malignant neoplasia central nervous system. The rate survival at 5 years, from moment diagnosis, not higher than 10%. Materials methods: In this retrospective study, fifty-four patients diagnosed with glioblastoma, Pathology Department County Emergency Clinical Hospital Târgu Mureș, between 2014 2017 were included. We studied clinico-pathological data (age, gender, location, laterality) and, respectively, immunoexpression p53, Ki67, ATRX, IDH-1 proteins. Results: observed a statistically significant association laterality according age groups, localization on right side being more frequent in group below 65 years age, while involvement left hemisphere was prevalent those over years. Out total 54 cases, 87.04% found be primary glioblastomas; 70% cases ATRX immunopositive; almost 80% glioblastomas had wild-type p53 profile; 35% have Ki67 index greater 20%. gender mutation found; female immunopositive 92% cases. Almost both wild-type, we presence mutations only 3.7% Approximately 83% positive, all mutant negative. Conclusions: Glioblastomas still represent multidisciplinary challenge considering their reserved prognosis. described characteristics IHC marker expression profiles, highlighting variety percentage ranges secondary glioblastomas. Given small number further prospective studies larger cohorts are needed future evaluate role these immunohistochemical markers as prognostic factors for or recurrence.

Language: Английский

Citations

3