Effect of nHA/CS/PLGA delivering adipose stem cell-derived exosomes and bone marrow stem cells on bone healing—in vitro and in vivo studies DOI Creative Commons
Ting Wang, Shu Guo, Ye Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Adipose stem cell-derived exosomes (ADSC-EXO) have been demonstrated to promote osteogenic differentiation of bone marrow cells (BMSCs) and facilitate regeneration. The present study aims investigate the effect ADSC-EXO-loaded nano-hydroxyapatite/chitosan/poly-lactide-co-glycolide (nHA/CS/PLGA) scaffolds on maxillofacial regeneration using tissue engineering. ADSC-EXO was isolated co-cultured with BMSCs, BMSCs assessed through detection mineralized nodule formation, alkaline phosphatase (ALP) activity, mRNA expression COL1A1 runt-related transcription factor 2 (RUNX2). nHA/CS/PLGA were fabricated loaded these engineering complexes applied defect region rabbits elucidate their effect. markedly enhanced when they ADSC-EXO. This evidenced by an increase in formation ALP In vivo experiments that application effectively repaired defects rabbits. has BMSCs. shown defects. may serve as a potential therapeutic strategy for large-scale

Language: Английский

Polylactic Acid/Calcium Silicate Composite Scaffold Fabricated by Selective Laser Sintering with Coordinated Regulation of Bioactivity Induction, Degradation, and Mechanical Enhancement DOI
Dongying Li, Yanrong Zhou, Peng Chen

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

1
Isogeometric topology optimization for innovative designs of the reinforced TPMS unit cells with curvy stiffeners using T-splines DOI
Xiao Zhang, Mi Xiao, Wei Luo

et al.

Composite Structures, Journal Year: 2025, Volume and Issue: unknown, P. 118955 - 118955

Published: Feb. 1, 2025

Language: Английский

Citations

0
Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review DOI Creative Commons
Siyuan Chen, Zhenzhen Wu, Ziqi Huang

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Background: Periodontitis and bone loss in the maxillofacial dental areas pose considerable challenges for both functional aesthetic outcomes. To date, implantable barrier membranes, designed to prevent epithelial migration into defects create a favorable environment targeted cells, have garnered significant interest from researchers. Consequently, variety of materials fabrication methods been explored extensive research on regenerative membranes. Methods: This review focuses summarizing various biomaterials used membrane manufacturing, methods, state-of-the-art applications tissue regeneration. Based discussion pros cons current strategies, future directions improved designs are proposed. Results conclusion: endow membranes with biological properties that accommodate different clinical situations, numerous manufacturing These approaches provide theoretical support hold promise advancements

Language: Английский

Citations

0
A calcium sulfate hemihydrate self-setting interface reinforced polycaprolactone porous composite scaffold DOI Creative Commons
Changfeng Li, Dongying Li, Yong Xu

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(11), P. 8430 - 8442

Published: Jan. 1, 2025

Mechanical enhancement mechanism of calcium sulfate hemihydrate self-setting.

Language: Английский

Citations

0
Stress Strain Curve Analysis of Sheet Based TPMS Structures in Quasi Static Compression Test: A Review DOI Creative Commons

Izzat bin Mat Samudin,

Nabilah Afiqah Mohd Radzuan, Abu Bakar Sulong

et al.

Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
3D‐Printed Scaffolds for Cranial Bone Regeneration: A Systematic Review of Design, Materials, and Computational Optimization DOI

Elnaz Khorasani,

Bahman Vahidi

Biotechnology and Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

ABSTRACT Cranial bone defects from trauma, congenital conditions, or surgery are challenging to treat due the skull's limited regeneration. Traditional methods like autografts and allografts have drawbacks, including donor site issues poor integration. 3D‐printed scaffolds provide a patient‐specific alternative, improving regeneration This review evaluates advancements in for cranial regeneration, focusing on fabrication techniques, material innovations, structural optimization while assessing their preclinical clinical potential. A systematic literature search (2014–2024) was conducted using PubMed other databases. Studies addressing scaffold properties such as porosity, pore interconnectivity, mechanical stability were included, non‐cranial studies excluded. Advances 3D printing enabled with optimized architecture enhance support, nutrient transport. Bioceramics, polymers, composites mimic native properties, bioactive coatings further improve osteogenesis. However, translation insufficient customization remain challenges. Further trials crucial overcoming barriers fabrication, bridging gap between research applications.

Language: Английский

Citations

0
The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress DOI Creative Commons
Lin Song,

Bozhao Wang,

Jian Li

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 624 - 624

Published: April 27, 2025

Klotho, an anti-aging protein, has been extensively studied in systemic conditions such as chronic kidney disease and cardiovascular disorders. In recent years, its pivotal protective role clinical significance various oral maxillofacial diseases have increasingly demonstrated. It demonstrated that Klotho regulates oxidative stress, apoptosis, inflammation, fibrosis via multiple molecular signaling pathways, including Nrf2, NF-κB, PI3K/Akt/FoxO1, insulin/IGF-1, FGF/FGFR, Wnt/β-catenin. Consequently, these regulatory effects observed periodontitis, squamous cell carcinoma, malignant salivary gland tumors, submucous fibrosis, etc. Moreover, the decreased expression or dysfunctional activity of is frequently associated with onset progression diseases. This study provides a comprehensive review underlying mechanisms advances research within realm diseases, offering novel perspectives for future basic investigations.

Language: Английский

Citations

0
Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) DOI Creative Commons

Judit Bóvári‐Biri,

Judith A Miskei,

Zsanett Kövér

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 145 - 145

Published: Jan. 20, 2025

Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds shown promise in addressing these challenges, regenerating this region remains complex due to its irregular shape, intricate structure, differing cellular origins compared other bones the human body. Moreover, significant variable mechanical loads placed maxillofacial add further complexity, especially cases of difficult-to-treat medical conditions. This review provides brief overview medication-related osteonecrosis jaw (MRONJ), highlighting medication-induced adverse reactions associated clinical challenges treating condition. The purpose manuscript is emphasize role biotechnology tissue engineering technologies therapy. By using scaffold materials biofactors combination with autologous cells, innovative solutions are explored for repair damaged bones. ongoing search effective that address improve vitro preparation subsequent regeneration critical. primary spotlight current research trends novel approaches area.

Language: Английский

Citations

0
Tailored 3D Lattice Microstructures for Enhanced Functionality in Blood‐Gas Exchange DOI Creative Commons

Kai P. Barbian,

Teresa Lemainque,

Ina Grunden

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Current membrane oxygenators for extracorporeal life support (ECLS) are facing their limits regarding gas exchange efficiency and long‐term stability. One aspect adding to these limitations is inhomogeneous blood flow distribution inside the oxygenator's structure. Triply periodic minimal surface (TPMS) lattice structures proposed provide increased mass transfer local adaptability introducing heterogeneous properties. However, adaptation of flow, as in ECLS, challenging a hemocompatible must be established. In this study, study proposes novel method smooth, multi‐scale modification TPMS creating tailored suited blood‐gas exchange. It implements into an automatic structure optimization within oxygenator. After manufacturing prototypes, it experimentally evaluate 3D using time‐resolved, contrast enhanced computed tomography comparing optimized reference geometries. The provides significant change distribution, improving homogeneity by up 12%. approach can directly transferred various other applications field heat enhance functionality, e.g., exchangers or contactors.

Language: Английский

Citations

0
Effect of nHA/CS/PLGA delivering adipose stem cell-derived exosomes and bone marrow stem cells on bone healing—in vitro and in vivo studies DOI Creative Commons
Ting Wang, Shu Guo, Ye Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Adipose stem cell-derived exosomes (ADSC-EXO) have been demonstrated to promote osteogenic differentiation of bone marrow cells (BMSCs) and facilitate regeneration. The present study aims investigate the effect ADSC-EXO-loaded nano-hydroxyapatite/chitosan/poly-lactide-co-glycolide (nHA/CS/PLGA) scaffolds on maxillofacial regeneration using tissue engineering. ADSC-EXO was isolated co-cultured with BMSCs, BMSCs assessed through detection mineralized nodule formation, alkaline phosphatase (ALP) activity, mRNA expression COL1A1 runt-related transcription factor 2 (RUNX2). nHA/CS/PLGA were fabricated loaded these engineering complexes applied defect region rabbits elucidate their effect. markedly enhanced when they ADSC-EXO. This evidenced by an increase in formation ALP In vivo experiments that application effectively repaired defects rabbits. has BMSCs. shown defects. may serve as a potential therapeutic strategy for large-scale

Language: Английский

Citations

0