Cladosporium species novum Invasive Pulmonary Infection in a Patient with Post-COVID-19 Syndrome and AIDS
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(6), P. 781 - 781
Published: March 20, 2025
Background
and
Clinical
Significance:
Since
the
prevalence
of
fungal
lung
infections
is
increasing,
certain
agents,
such
as
Cladosporium
spp.,
have
emerged
unexpected
causes.
spp.
fungi
are
ubiquitous
in
environments
soil,
fruits,
wine
corks;
they
a
part
normal
human
skin
flora;
known
respiratory
allergens.
Case
Presentation:
A
patient
with
history
post-COVID-19
syndrome
AIDS
presented
pathology
indicative
an
invasive
infection.
The
initial
histopathological
examination
revealed
numerous
yeast-like
cells
narrow-based
budding,
which
led
to
mistaken
diagnosis
cryptococcosis.
However,
further
detailed
sparse
hyphae
tissue,
suggesting
more
complex
Molecular
analyses
sequence
BLAST
alignment
were
performed,
ultimately
identifying
infectious
agent
“Cladosporium
species
novum”,
rare
cause
pulmonary
cladosporiasis.
Conclusions:
Invasive
cladosporiasis
condition,
morphological
features
fungus
alone
insufficient
establish
correct
diagnosis.
comprehensive
pathohistological
molecular
approach
bioinformatics
tools
essential
for
identification
potentially
life-threatening
pathogens
immunocompromised
patients.
Language: Английский
Challenges of diagnosis of hidden fungal infections as sequelae in post-coronavirus disease patients
Reviews in Medical Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
More
than
700
million
people
worldwide
have
been
confirmed
to
coronavirus
disease
2019
(COVID-19),
putting
them
at
risk
of
developing
sequelae
that
are
prone
invasive
fungal
infections
(IFIs),
such
as
candidiasis,
aspergillosis,
and
cryptococcosis.
These
fungi
generally
not
virulent,
but
in
patients
with
a
history
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
they
can
cause
opportunistic
due
immune
dysregulation
abnormalities
lung
tissue
structure
caused
by
the
effects
SARS-CoV-2
virus,
using
immunosuppressive
drugs
or
medical
devices
during
treatment,
so
on.
The
increased
susceptibility
IFIs
individuals
post-COVID-19
requires
rapid
efficient
diagnostic
methods.
Currently,
commercially
available
antigen-based
serological
tests
good
sensitivity
specificity,
some
approved
for
use
Food
Drug
Administration.
Thus,
screening
essential
regions
limited
resources.
Language: Английский
Update on invasive fungal infections: emerging trends in the incidence of fungal infections in immunosuppressed patients and associated conditions
Therapeutic Advances in Infectious Disease,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Language: Английский
Post COVID-19 and fungal pathogens coinfection in Africa – current status and future directions
The Microbe,
Journal Year:
2024,
Volume and Issue:
4, P. 100152 - 100152
Published: Aug. 24, 2024
COVID-19
is
no
longer
a
PHEIC,
though
this
comes
with
long-term
plan
to
manage
the
disease
through
vaccination.
almost
left
behind
new
form
of
disease,
post-acute
sequelae
(long
COVID)
which
evolving
likely
pose
healthcare
challenge.
Currently,
Africa
yet
understand
prevalence
and
nature
long
COVID,
as
well
best
practices
in
diagnosis,
treatment
control
impact
on
management
fungal
infections.
It
not
clear
what
extent
it
affecting
lives
Africans.,
Therefore,
more
research
needed
pathogenesis
COVID
burden
coinfections
help
establish
efficient
approaches
before
evolves
into
serious
concern.
Language: Английский