Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1544 - 1544

Published: Dec. 17, 2024

A large number of cases infectious colitis caused by multidrug-resistant (MDR) bacteria, such as Escherichia coli, can result in colon damage and severe inflammation. Vanilla, a widely utilized flavor fragrance compound, is extensively used various food. However, the effect vanilla on MDR E. coli-induced has received less attention. In this study, antibacterial activity vanillin against coli other bacteria was determined microtiter broth dilution method. The antioxidant anti-inflammatory capacity assessed lipopolysaccharide (LPS)-stimulated RAW 264.7 cells mouse colitis. results demonstrated that exhibited potent strains Salmonella, Staphylococcus aureus, with minimal inhibitory concentration (MIC) 1.25–2.5 mg/mL minimum bactericidal (MBC) 5–10 mg/mL; it effectively inhibited cell division coli. Vanillin also displayed remarkable suppressing levels malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS) LPS-stimulated cell; significantly reduced production inflammatory mediators including nitroxide (NO), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), 1β (IL-1β), while increasing 10 (IL-10). an model, inflammation cytokines, mitogen-activated protein kinase (MAPK), nuclear κ-B (NF-κB) signaling pathway activation; ameliorated changes intestinal microflora characterized decreased Firmicutes richness alongside increased Bacteroides richness, rebalancing dysbiosis These findings highlight potential pharmacological applicability promising bioactive molecule for treating

Language: Английский