Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia.
Courtney Linne,

Khine Yin Mon,

Shane P. D’Souza

et al.

PubMed, Journal Year: 2023, Volume and Issue: 29, P. 39 - 57

Published: Jan. 1, 2023

Myopia, or nearsightedness, is the most common form of refractive error and increasing in prevalence. While significant efforts have been made to identify genetic variants that predispose individuals myopia, these are believed account for only a small portion myopia prevalence, leading feedback theory emmetropization, which depends on active perception environmental visual cues. Consequently, there has renewed interest studying context light perception, beginning with opsin family G-protein coupled receptors (GPCRs). Refractive phenotypes characterized every signaling pathway studied, leaving Opsin 3 (OPN3), widely expressed blue-light sensing noncanonical opsin, be investigated function eye refraction.Opn3 expression was assessed various ocular tissues using an Opn3eGFP reporter. Weekly development Opn3 retinal germline mutants from 9 weeks age measured infrared photorefractor spectral domain optical coherence tomography (SD-OCT). Susceptibility lens-induced then skull-mounted goggles -30 diopter experimental 0 control lens. Mouse biometry similarly tracked 6 weeks. A gene signature 24 h after lens induction further assess myopia-induced changes.Opn3 found subset ganglion cells limited number choroidal cells. Based assessment mutants, OPN3 germline, but not retina conditional knockout, exhibits phenotype, manifests decreased thickness, shallower aqueous compartment depth, shorter axial length, atypical traditional myopias. Despite short null eyes demonstrate normal elongation response mild changes thinning myopic shift, suggesting susceptibility largely unchanged. Additionally, induced distinct, opposing Ctgf, Cx43, Egr1 polarity compared controls.The data suggest outside can shape thus performance eye. Prior this study, role had investigated. This work adds list GPCRs implicated emmetropization myopia. Further, exclude as contributing phenotype unique suggests distinct mechanism when other opsins.

Language: Английский

Assessing the utility of ChatGPT as an artificial intelligence‐based large language model for information to answer questions on myopia DOI Creative Commons
Sayantan Biswas, Nicola S. Logan,

Leon N. Davies

et al.

Ophthalmic and Physiological Optics, Journal Year: 2023, Volume and Issue: 43(6), P. 1562 - 1570

Published: July 21, 2023

Abstract Purpose ChatGPT is an artificial intelligence language model, which uses natural processing to simulate human conversation. It has seen a wide range of applications including healthcare education, research and clinical practice. This study evaluated the accuracy in providing accurate quality information answer questions on myopia. Methods A series 11 (nine categories general summary, cause, symptom, onset, prevention, complication, history, treatment prognosis) were generated for this cross‐sectional study. Each question was entered five times into fresh sessions (free from influence prior questions). The responses by five‐member team optometry teaching staff. evaluators individually rated Likert scale, where higher score indicated greater (1: very poor; 2: 3: acceptable; 4: good; 5: good). Median scores each estimated compared between evaluators. Agreement reliability statistics estimated. Results Of myopia, provided good (median scores: 4.0) 10 acceptable 3.0) one question. Out 275 total, 66 (24%) good, 134 (49%) whereas 60 (22%) acceptable, (3.6%) poor 5 (1.8%) poor. Cronbach's α 0.807 level agreement test items. Evaluators' ratings demonstrated ‘slight agreement’ (Fleiss's κ , 0.005) with significant difference scoring among (Kruskal–Wallis test, p < 0.001). Conclusion Overall, Although shows great potential rapidly presence inaccurate demonstrates that further evaluation awareness concerning its limitations are crucial avoid misinterpretation.

Language: Английский

Citations

63

The influence of the environment and lifestyle on myopia DOI Creative Commons
Sayantan Biswas,

Antonio El Kareh,

Mariyem Qureshi

et al.

Journal of PHYSIOLOGICAL ANTHROPOLOGY, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 31, 2024

Abstract Background Myopia, commonly known as near-sightedness, has emerged a global epidemic, impacting almost one in three individuals across the world. The increasing prevalence of myopia during early childhood heightened risk developing high and related sight-threatening eye conditions adulthood. This surge rates, occurring within relatively stable genetic framework, underscores profound influence environmental lifestyle factors on this condition. In comprehensive narrative review, we shed light both established potential contributors that affect development progression myopia. Main body Epidemiological interventional research consistently revealed compelling connection between increased outdoor time decreased children. protective effect may primarily be attributed to exposure characteristics natural (i.e., sunlight) release retinal dopamine. Conversely, irrespective time, excessive engagement near work can further worsen onset While exact mechanisms behind exacerbation are not fully comprehended, it appears involve shifts relative peripheral refraction, overstimulation accommodation, or complex interplay these factors, leading issues like image defocus, blur, chromatic aberration. Other spatial frequency visual environment, circadian rhythm, sleep, nutrition, smoking, socio-economic status, education have debatable independent influences development. Conclusion environment exerts significant Improving modifiable key predictors spent outdoors prevent slow intricate connections often obscure findings, making challenging disentangle their individual effects. complexity necessity for prospective studies employ objective assessments, such quantifying work, among others. These crucial gaining more understanding how various modified

Language: Английский

Citations

59

IMI 2023 Digest DOI Creative Commons
Padmaja Sankaridurg, David A. Berntsen, Mark A. Bullimore

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2023, Volume and Issue: 64(6), P. 7 - 7

Published: May 1, 2023

Myopia is a dynamic and rapidly moving field, with ongoing research providing better understanding of the etiology leading to novel myopia control strategies. In 2019, International Institute (IMI) assembled published series white papers across relevant topics updated evidence digest in 2021. Here, we summarize findings key from previous 2 years. Studies animal models have continued explore how wavelength intensity light influence eye growth examined new pharmacologic agents scleral cross-linking as potential strategies for slowing myopia. children, term premyopia gaining interest increased attention early implementation control. Most studies use IMI definitions ≤-0.5 diopters (D) ≤-6.0 D high myopia, although categorization structural consequences remain an issue. Clinical trials demonstrated that newer spectacle lens designs incorporating multiple segments, lenslets, or diffusion optics exhibit good efficacy. considerations factors influencing efficacy soft multifocal contact lenses orthokeratology are discussed. Topical atropine remains only widely accessible treatment. Rebound observed higher concentration not evident lower concentrations optical interventions. Overall, treatments show little adverse effect on visual function appear generally safe, longer wear times combination therapies maximizing outcomes. An emerging category light-based children requires comprehensive safety data enable risk versus benefit analysis. Given success strategies, ethics including arm clinical heavily debated. recommendations trial protocols

Language: Английский

Citations

53

Efficacy of Repeated Low-Level Red Light (RLRL) therapy on myopia outcomes in children: a systematic review and meta-analysis DOI Creative Commons
Mohamed Ashraf Youssef,

Ahmed Ragab Shehata,

Ahmed Moataz Adly

et al.

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 20, 2024

Abstract Background Myopia is the most prevalent form of refractive error that has a major negative impact on visual function and causes blurring vision. We aimed to determine if Repeated Low-Level Red Light (RLRL) treatment beneficial in treating childhood myopia terms axial length (AL), spherical equivalent refraction (SER), sub foveal choroidal thickness (SFCT). Methods This systematic review was performed RLRL for children compared single vision spectacles (SVS). employed search strategy with key low-level light therapy then we searched PubMed, Scopus, Cochrane, Web Science databases. The mean differences (MD) were used evaluate effects. Heterogeneity quantified using I 2 statistics explored by sensitivity analysis. Results Five randomized controlled trials (RCTs) included our meta-analysis total 833 patients, 407 group 426 control group. At 3 month follow up period, pooled studies show statistical difference AL between SVS (MD = -0.16; 95% CI [-0.19, -0.12], SER 0.33; [0.27, 0.38]), SFCT 43.65; [23.72, 45.58]). 6 -0.21; [-0.28, -0.15]), 0.46; [0.26, 0.65]), 25.07; [18.18, 31.95]). 12 -0.31; [-0.42, -0.19]) 0.63; [0.52, 0.73]). Conclusion first investigating only RCTs evidence supporting efficacy 650 nm short term 3, 6, months up. present revealed clinical significance as new alternative good user acceptability no documented functional or structural damage. However, effect long-term rebound after cessation require further investigations.

Language: Английский

Citations

11

Safety of repeated low-level red-light therapy for children with myopia DOI Creative Commons

Mengxia Zhu,

Ying Liu,

Dengqin Fang

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 47, P. 104198 - 104198

Published: May 8, 2024

To investigate the safety of repetitive low-level red-light therapy (RLRLT) in children with myopia.

Language: Английский

Citations

10

The whole life cycle myopia management DOI Creative Commons

Moxin Chen,

Shu Qin, Fang Li

et al.

Asia-Pacific Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown, P. 100161 - 100161

Published: Jan. 1, 2025

Myopia stands as a prevalent ocular condition with global implications, impacting individuals at various life stages. In school-age children and adolescents, uncorrected myopia impedes reading academic performance. Among middle-aged elderly populations, poses severe risks such macular degeneration, holes retinal detachment, leading to irreversible visual impairment. The term "myopia management" is widely embraced by ophthalmic practitioners optometry associations worldwide, encompassing strategies correct refractive errors ongoing assessment of disease progression, aiming reduce the progression axial elongation. To date, current management for include public health policies, optical solutions, medical interventions surgical options, but these are general lack age specificity. Despite existing interventions, we propose concept "Whole Life Cycle Management" in this review. This approach outlined major risk factors through whole cycle, discussed provided age-specific eight different stages-infancies, toddlers, preschoolers, children, young adults, middle-age old-age, including prevention onset, slowing monitoring complications. Achieving requires collaborations efforts from government, schools, hospitals families, restore vision enhance quality those affected myopia.

Language: Английский

Citations

1

Interventions for myopia control in children: a living systematic review and network meta-analysis DOI
John G Lawrenson, Byki Huntjens, Gianni Virgili

et al.

Cochrane library, Journal Year: 2025, Volume and Issue: 2025(2)

Published: Feb. 13, 2025

Language: Английский

Citations

1

Measuring light exposure in daily life: A review of wearable light loggers DOI Creative Commons
J. van Duijnhoven, Steffen Hartmeyer, Altuğ Didikoğlu

et al.

Building and Environment, Journal Year: 2025, Volume and Issue: unknown, P. 112771 - 112771

Published: Feb. 1, 2025

Language: Английский

Citations

1

Prevalence and associated factors of myopia among adolescents aged 12–15 in Shandong Province, China: a cross-sectional study DOI Creative Commons
Zhihao Huang,

Dingding Song,

Zhiqi Tian

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 27, 2024

Myopia is a growing concern worldwide, especially among adolescents. This study aimed to investigate the prevalence and associated factors of myopia in adolescents aged 12-15 Shandong Province, China. cross-sectional adhered Strengthening Reporting Observational Studies Epidemiology guidelines involved stratified random cluster sampling 128,678 students from 186 middle schools across 17 cities Province. Data collection was conducted March April 2024. We excluded with organic eye diseases, abnormal binocular vision functions, or history injuries surgeries. assessed using standard logarithmic visual acuity chart autorefractor without inducing ciliary muscle paralysis. A comprehensive questionnaire survey gather demographic characteristics daily life behaviors. With chi-squared test for univariable analysis multivariable logistic regression identifying significant factors. included 126,375 participants, gender distribution 51.02% male 48.98% female. The overall 71.34%. Higher observed girls (72.26%) compared boys (70.45%), increased age, peaking at 73.12% 15-year-olds. Urban residents had higher (71.86%) than rural (70.39%). Factors such as frequency usage while lying down leaning forward, frequent use eyes walking riding car, prolonged screen time, extended homework duration were odds developing myopia. Conversely, outdoor exercise, maintaining proper posture during reading writing, greater distance screen, longer sleep lower odds. Additionally, female gender, older urban residence, parental risk. high Province influenced by combination demographic, behavioral, environmental highlighted importance lifestyle modifications, increasing activities habits, limiting exposure sessions, extending duration, mitigate risk These findings underscored need targeted public health interventions educational campaigns address this issue.

Language: Английский

Citations

8

A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control DOI Creative Commons
Sayantan Biswas,

Arumugam Ramachandran Muralidharan,

Bjorn Kaijun Betzler

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2023, Volume and Issue: 64(3), P. 31 - 31

Published: March 23, 2023

Purpose: To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) unrestricted vision (UnV) on lens-induced myopia (LIM) development in chickens. Methods: Myopia was induced one eye chicks (10 groups, n = 126) from day 1 posthatching (D1) until 8 (D8) using –10 diopter (D) lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to 2, 4, or 6 hours HL (15,000 lux), UnV (removal D lens), both (HL + UnV). One group served LIM without any interventions. Ocular axial length (AL), refractive error, choroidal thickness measured D1, D4, D8. Outcome measures are expressed interocular difference (IOD experimental – control eye) ± SEM. Results: By D8, increased AL (0.36 0.04 mm), myopic refraction (−9.02 0.37 D), thinning (−90.27 16.44 µm) (all, P < 0.001). Compared group, exposure HL, UnV, reduced a manner, with being more effective than (P 0.05). Only (not 2 4 hours) prevented 0.004) 0.001) reducing elongation. Conclusions: Daily manner completely stopped development. The effect is dependent duration

Language: Английский

Citations

13