PubMed,
Journal Year:
2023,
Volume and Issue:
29, P. 39 - 57
Published: Jan. 1, 2023
Myopia,
or
nearsightedness,
is
the
most
common
form
of
refractive
error
and
increasing
in
prevalence.
While
significant
efforts
have
been
made
to
identify
genetic
variants
that
predispose
individuals
myopia,
these
are
believed
account
for
only
a
small
portion
myopia
prevalence,
leading
feedback
theory
emmetropization,
which
depends
on
active
perception
environmental
visual
cues.
Consequently,
there
has
renewed
interest
studying
context
light
perception,
beginning
with
opsin
family
G-protein
coupled
receptors
(GPCRs).
Refractive
phenotypes
characterized
every
signaling
pathway
studied,
leaving
Opsin
3
(OPN3),
widely
expressed
blue-light
sensing
noncanonical
opsin,
be
investigated
function
eye
refraction.Opn3
expression
was
assessed
various
ocular
tissues
using
an
Opn3eGFP
reporter.
Weekly
development
Opn3
retinal
germline
mutants
from
9
weeks
age
measured
infrared
photorefractor
spectral
domain
optical
coherence
tomography
(SD-OCT).
Susceptibility
lens-induced
then
skull-mounted
goggles
-30
diopter
experimental
0
control
lens.
Mouse
biometry
similarly
tracked
6
weeks.
A
gene
signature
24
h
after
lens
induction
further
assess
myopia-induced
changes.Opn3
found
subset
ganglion
cells
limited
number
choroidal
cells.
Based
assessment
mutants,
OPN3
germline,
but
not
retina
conditional
knockout,
exhibits
phenotype,
manifests
decreased
thickness,
shallower
aqueous
compartment
depth,
shorter
axial
length,
atypical
traditional
myopias.
Despite
short
null
eyes
demonstrate
normal
elongation
response
mild
changes
thinning
myopic
shift,
suggesting
susceptibility
largely
unchanged.
Additionally,
induced
distinct,
opposing
Ctgf,
Cx43,
Egr1
polarity
compared
controls.The
data
suggest
outside
can
shape
thus
performance
eye.
Prior
this
study,
role
had
investigated.
This
work
adds
list
GPCRs
implicated
emmetropization
myopia.
Further,
exclude
as
contributing
phenotype
unique
suggests
distinct
mechanism
when
other
opsins.
Ophthalmic and Physiological Optics,
Journal Year:
2023,
Volume and Issue:
43(6), P. 1562 - 1570
Published: July 21, 2023
Abstract
Purpose
ChatGPT
is
an
artificial
intelligence
language
model,
which
uses
natural
processing
to
simulate
human
conversation.
It
has
seen
a
wide
range
of
applications
including
healthcare
education,
research
and
clinical
practice.
This
study
evaluated
the
accuracy
in
providing
accurate
quality
information
answer
questions
on
myopia.
Methods
A
series
11
(nine
categories
general
summary,
cause,
symptom,
onset,
prevention,
complication,
history,
treatment
prognosis)
were
generated
for
this
cross‐sectional
study.
Each
question
was
entered
five
times
into
fresh
sessions
(free
from
influence
prior
questions).
The
responses
by
five‐member
team
optometry
teaching
staff.
evaluators
individually
rated
Likert
scale,
where
higher
score
indicated
greater
(1:
very
poor;
2:
3:
acceptable;
4:
good;
5:
good).
Median
scores
each
estimated
compared
between
evaluators.
Agreement
reliability
statistics
estimated.
Results
Of
myopia,
provided
good
(median
scores:
4.0)
10
acceptable
3.0)
one
question.
Out
275
total,
66
(24%)
good,
134
(49%)
whereas
60
(22%)
acceptable,
(3.6%)
poor
5
(1.8%)
poor.
Cronbach's
α
0.807
level
agreement
test
items.
Evaluators'
ratings
demonstrated
‘slight
agreement’
(Fleiss's
κ
,
0.005)
with
significant
difference
scoring
among
(Kruskal–Wallis
test,
p
<
0.001).
Conclusion
Overall,
Although
shows
great
potential
rapidly
presence
inaccurate
demonstrates
that
further
evaluation
awareness
concerning
its
limitations
are
crucial
avoid
misinterpretation.
Journal of PHYSIOLOGICAL ANTHROPOLOGY,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Jan. 31, 2024
Abstract
Background
Myopia,
commonly
known
as
near-sightedness,
has
emerged
a
global
epidemic,
impacting
almost
one
in
three
individuals
across
the
world.
The
increasing
prevalence
of
myopia
during
early
childhood
heightened
risk
developing
high
and
related
sight-threatening
eye
conditions
adulthood.
This
surge
rates,
occurring
within
relatively
stable
genetic
framework,
underscores
profound
influence
environmental
lifestyle
factors
on
this
condition.
In
comprehensive
narrative
review,
we
shed
light
both
established
potential
contributors
that
affect
development
progression
myopia.
Main
body
Epidemiological
interventional
research
consistently
revealed
compelling
connection
between
increased
outdoor
time
decreased
children.
protective
effect
may
primarily
be
attributed
to
exposure
characteristics
natural
(i.e.,
sunlight)
release
retinal
dopamine.
Conversely,
irrespective
time,
excessive
engagement
near
work
can
further
worsen
onset
While
exact
mechanisms
behind
exacerbation
are
not
fully
comprehended,
it
appears
involve
shifts
relative
peripheral
refraction,
overstimulation
accommodation,
or
complex
interplay
these
factors,
leading
issues
like
image
defocus,
blur,
chromatic
aberration.
Other
spatial
frequency
visual
environment,
circadian
rhythm,
sleep,
nutrition,
smoking,
socio-economic
status,
education
have
debatable
independent
influences
development.
Conclusion
environment
exerts
significant
Improving
modifiable
key
predictors
spent
outdoors
prevent
slow
intricate
connections
often
obscure
findings,
making
challenging
disentangle
their
individual
effects.
complexity
necessity
for
prospective
studies
employ
objective
assessments,
such
quantifying
work,
among
others.
These
crucial
gaining
more
understanding
how
various
modified
Investigative Ophthalmology & Visual Science,
Journal Year:
2023,
Volume and Issue:
64(6), P. 7 - 7
Published: May 1, 2023
Myopia
is
a
dynamic
and
rapidly
moving
field,
with
ongoing
research
providing
better
understanding
of
the
etiology
leading
to
novel
myopia
control
strategies.
In
2019,
International
Institute
(IMI)
assembled
published
series
white
papers
across
relevant
topics
updated
evidence
digest
in
2021.
Here,
we
summarize
findings
key
from
previous
2
years.
Studies
animal
models
have
continued
explore
how
wavelength
intensity
light
influence
eye
growth
examined
new
pharmacologic
agents
scleral
cross-linking
as
potential
strategies
for
slowing
myopia.
children,
term
premyopia
gaining
interest
increased
attention
early
implementation
control.
Most
studies
use
IMI
definitions
≤-0.5
diopters
(D)
≤-6.0
D
high
myopia,
although
categorization
structural
consequences
remain
an
issue.
Clinical
trials
demonstrated
that
newer
spectacle
lens
designs
incorporating
multiple
segments,
lenslets,
or
diffusion
optics
exhibit
good
efficacy.
considerations
factors
influencing
efficacy
soft
multifocal
contact
lenses
orthokeratology
are
discussed.
Topical
atropine
remains
only
widely
accessible
treatment.
Rebound
observed
higher
concentration
not
evident
lower
concentrations
optical
interventions.
Overall,
treatments
show
little
adverse
effect
on
visual
function
appear
generally
safe,
longer
wear
times
combination
therapies
maximizing
outcomes.
An
emerging
category
light-based
children
requires
comprehensive
safety
data
enable
risk
versus
benefit
analysis.
Given
success
strategies,
ethics
including
arm
clinical
heavily
debated.
recommendations
trial
protocols
BMC Ophthalmology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 20, 2024
Abstract
Background
Myopia
is
the
most
prevalent
form
of
refractive
error
that
has
a
major
negative
impact
on
visual
function
and
causes
blurring
vision.
We
aimed
to
determine
if
Repeated
Low-Level
Red
Light
(RLRL)
treatment
beneficial
in
treating
childhood
myopia
terms
axial
length
(AL),
spherical
equivalent
refraction
(SER),
sub
foveal
choroidal
thickness
(SFCT).
Methods
This
systematic
review
was
performed
RLRL
for
children
compared
single
vision
spectacles
(SVS).
employed
search
strategy
with
key
low-level
light
therapy
then
we
searched
PubMed,
Scopus,
Cochrane,
Web
Science
databases.
The
mean
differences
(MD)
were
used
evaluate
effects.
Heterogeneity
quantified
using
I
2
statistics
explored
by
sensitivity
analysis.
Results
Five
randomized
controlled
trials
(RCTs)
included
our
meta-analysis
total
833
patients,
407
group
426
control
group.
At
3
month
follow
up
period,
pooled
studies
show
statistical
difference
AL
between
SVS
(MD
=
-0.16;
95%
CI
[-0.19,
-0.12],
SER
0.33;
[0.27,
0.38]),
SFCT
43.65;
[23.72,
45.58]).
6
-0.21;
[-0.28,
-0.15]),
0.46;
[0.26,
0.65]),
25.07;
[18.18,
31.95]).
12
-0.31;
[-0.42,
-0.19])
0.63;
[0.52,
0.73]).
Conclusion
first
investigating
only
RCTs
evidence
supporting
efficacy
650
nm
short
term
3,
6,
months
up.
present
revealed
clinical
significance
as
new
alternative
good
user
acceptability
no
documented
functional
or
structural
damage.
However,
effect
long-term
rebound
after
cessation
require
further
investigations.
Asia-Pacific Journal of Ophthalmology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100161 - 100161
Published: Jan. 1, 2025
Myopia
stands
as
a
prevalent
ocular
condition
with
global
implications,
impacting
individuals
at
various
life
stages.
In
school-age
children
and
adolescents,
uncorrected
myopia
impedes
reading
academic
performance.
Among
middle-aged
elderly
populations,
poses
severe
risks
such
macular
degeneration,
holes
retinal
detachment,
leading
to
irreversible
visual
impairment.
The
term
"myopia
management"
is
widely
embraced
by
ophthalmic
practitioners
optometry
associations
worldwide,
encompassing
strategies
correct
refractive
errors
ongoing
assessment
of
disease
progression,
aiming
reduce
the
progression
axial
elongation.
To
date,
current
management
for
include
public
health
policies,
optical
solutions,
medical
interventions
surgical
options,
but
these
are
general
lack
age
specificity.
Despite
existing
interventions,
we
propose
concept
"Whole
Life
Cycle
Management"
in
this
review.
This
approach
outlined
major
risk
factors
through
whole
cycle,
discussed
provided
age-specific
eight
different
stages-infancies,
toddlers,
preschoolers,
children,
young
adults,
middle-age
old-age,
including
prevention
onset,
slowing
monitoring
complications.
Achieving
requires
collaborations
efforts
from
government,
schools,
hospitals
families,
restore
vision
enhance
quality
those
affected
myopia.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 27, 2024
Myopia
is
a
growing
concern
worldwide,
especially
among
adolescents.
This
study
aimed
to
investigate
the
prevalence
and
associated
factors
of
myopia
in
adolescents
aged
12-15
Shandong
Province,
China.
cross-sectional
adhered
Strengthening
Reporting
Observational
Studies
Epidemiology
guidelines
involved
stratified
random
cluster
sampling
128,678
students
from
186
middle
schools
across
17
cities
Province.
Data
collection
was
conducted
March
April
2024.
We
excluded
with
organic
eye
diseases,
abnormal
binocular
vision
functions,
or
history
injuries
surgeries.
assessed
using
standard
logarithmic
visual
acuity
chart
autorefractor
without
inducing
ciliary
muscle
paralysis.
A
comprehensive
questionnaire
survey
gather
demographic
characteristics
daily
life
behaviors.
With
chi-squared
test
for
univariable
analysis
multivariable
logistic
regression
identifying
significant
factors.
included
126,375
participants,
gender
distribution
51.02%
male
48.98%
female.
The
overall
71.34%.
Higher
observed
girls
(72.26%)
compared
boys
(70.45%),
increased
age,
peaking
at
73.12%
15-year-olds.
Urban
residents
had
higher
(71.86%)
than
rural
(70.39%).
Factors
such
as
frequency
usage
while
lying
down
leaning
forward,
frequent
use
eyes
walking
riding
car,
prolonged
screen
time,
extended
homework
duration
were
odds
developing
myopia.
Conversely,
outdoor
exercise,
maintaining
proper
posture
during
reading
writing,
greater
distance
screen,
longer
sleep
lower
odds.
Additionally,
female
gender,
older
urban
residence,
parental
risk.
high
Province
influenced
by
combination
demographic,
behavioral,
environmental
highlighted
importance
lifestyle
modifications,
increasing
activities
habits,
limiting
exposure
sessions,
extending
duration,
mitigate
risk
These
findings
underscored
need
targeted
public
health
interventions
educational
campaigns
address
this
issue.
Investigative Ophthalmology & Visual Science,
Journal Year:
2023,
Volume and Issue:
64(3), P. 31 - 31
Published: March 23, 2023
Purpose:
To
evaluate
the
duration-dependent
and
synergetic
impact
of
high-intensity
light
(HL)
unrestricted
vision
(UnV)
on
lens-induced
myopia
(LIM)
development
in
chickens.
Methods:
Myopia
was
induced
one
eye
chicks
(10
groups,
n
=
126)
from
day
1
posthatching
(D1)
until
8
(D8)
using
–10
diopter
(D)
lenses.
Fellow
eyes
remained
uncovered
as
controls.
Nine
groups
were
exposed
daily
to
2,
4,
or
6
hours
HL
(15,000
lux),
UnV
(removal
D
lens),
both
(HL
+
UnV).
One
group
served
LIM
without
any
interventions.
Ocular
axial
length
(AL),
refractive
error,
choroidal
thickness
measured
D1,
D4,
D8.
Outcome
measures
are
expressed
interocular
difference
(IOD
experimental
–
control
eye)
±
SEM.
Results:
By
D8,
increased
AL
(0.36
0.04
mm),
myopic
refraction
(−9.02
0.37
D),
thinning
(−90.27
16.44
µm)
(all,
P
<
0.001).
Compared
group,
exposure
HL,
UnV,
reduced
a
manner,
with
being
more
effective
than
(P
0.05).
Only
(not
2
4
hours)
prevented
0.004)
0.001)
reducing
elongation.
Conclusions:
Daily
manner
completely
stopped
development.
The
effect
is
dependent
duration