Antibody-induced procoagulant platelets in severe COVID-19 infection DOI Open Access
Karina Althaus,

Irene Marini,

Jan Zlamal

et al.

Blood, Journal Year: 2020, Volume and Issue: 137(8), P. 1061 - 1071

Published: Dec. 23, 2020

Language: Английский

Post-acute COVID-19 syndrome DOI Creative Commons
Ani Nalbandian, Kartik Sehgal, Aakriti Gupta

et al.

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(4), P. 601 - 615

Published: March 22, 2021

Language: Английский

Citations

4340
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19 DOI Creative Commons
Aldo Bonaventura, Alessandra Vecchié, Lorenzo Dagna

et al.

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(5), P. 319 - 329

Published: April 6, 2021

Language: Английский

Citations

803
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas DOI Creative Commons
Xianwen Ren, Wen Wen, Xiaoying Fan

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(7), P. 1895 - 1913.e19

Published: Feb. 5, 2021

Language: Английский

Citations

729
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 DOI Creative Commons
Si Zhang, Yangyang Liu,

Xiaofang Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2020, Volume and Issue: 13(1)

Published: Sept. 4, 2020

Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at dramatically increased lethal risk. Although platelet activation is critical for thrombosis and responsible the thrombotic events cardiovascular complications, role of platelets in pathogenesis remains unclear.

Language: Английский

Citations

638
Interplay between inflammation and thrombosis in cardiovascular pathology DOI Open Access
Konstantin Stark, Steffen Maßberg

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(9), P. 666 - 682

Published: May 6, 2021

Language: Английский

Citations

584
Large-Scale Multi-omic Analysis of COVID-19 Severity DOI Creative Commons
Katherine A. Overmyer, Evgenia Shishkova, Ian Miller

et al.

Cell Systems, Journal Year: 2020, Volume and Issue: 12(1), P. 23 - 40.e7

Published: Oct. 8, 2020

We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from COVID-19-positive COVID-19-negative patients with diverse disease severities outcomes. Quantified transcripts, proteins, metabolites, lipids were associated clinical outcomes in a curated relational database, uniquely enabling systems analysis cross-ome correlations to molecules patient prognoses. mapped 219 molecular features high significance COVID-19 status severity, many of which involved complement activation, dysregulated lipid transport, neutrophil activation. identified sets covarying molecules, e.g., protein gelsolin metabolite citrate or plasmalogens apolipoproteins, offering pathophysiological insights therapeutic suggestions. The observed dysregulation platelet function, coagulation, acute phase response, endotheliopathy further illuminated the unique phenotype. present web-based tool (covid-omics.app) interactive exploration our compendium illustrate its utility through machine learning approach for prediction severity.

Language: Английский

Citations

544
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial DOI Creative Commons

Eugenia Abaleke,

Mustafa Abbas,

Sadia Abbasi

et al.

The Lancet, Journal Year: 2021, Volume and Issue: 397(10274), P. 605 - 612

Published: Feb. 1, 2021

Language: Английский

Citations

534
The Impact of COVID-19 Disease on Platelets and Coagulation DOI Creative Commons
Geoffrey D. Wool,

Jonathan Miller

Pathobiology, Journal Year: 2020, Volume and Issue: 88(1), P. 15 - 27

Published: Oct. 13, 2020

Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop severe proinflammatory state which can be associated with unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces prominent elevation fibrinogen D-dimer/fibrin(ogen) degradation products. This is systemic hypercoagulability frequent venous thromboembolic events. The degree D-dimer positively correlates mortality in patients. also leads to arterial thrombotic events (including strokes ischemic limbs) as well microvascular disorders (as frequently documented at autopsy the pulmonary vascular beds). often have mild thrombocytopenia appear increased platelet consumption, together corresponding increase production. Disseminated intravascular (DIC) bleeding are uncommon Here, we review current knowledge hemostasis.

Language: Английский

Citations

515
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19 DOI Open Access
Younes Zaid, Florian Puhm, Isabelle Allaeys

et al.

Circulation Research, Journal Year: 2020, Volume and Issue: 127(11), P. 1404 - 1418

Published: Sept. 17, 2020

In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated thrombosis. Moreover, they can interact viruses an important source inflammatory mediators. While a lower platelet count is associated severity mortality, little known about function during COVID-19.

Language: Английский

Citations

458
Pathophysiology of COVID-19-associated acute kidney injury DOI Creative Commons
Matthieu Legrand, Samira Bell, Lui G. Forni

et al.

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(11), P. 751 - 764

Published: July 5, 2021

Language: Английский

Citations

435