COVID-19: Sleep, Circadian Rhythms and Immunity – Repurposing Drugs and Chronotherapeutics for SARS-CoV-2 DOI Creative Commons

Allan Giri,

A. R. Srinivasan, Isaac K. Sundar

et al.

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: June 18, 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has affected nearly 28 million people in the United States and caused more than five hundred thousand deaths as of February 21, 2021. As novel continues to take its toll all across globe, particularly among elderly (>65 years), clinicians translational researchers are taking a closer look at nexus sleep, circadian rhythms immunity that may contribute toward disease-19 (COVID-19). SARS-CoV-2-induced multi-organ failure affects both central peripheral organs, causing increased mortality elderly. However, whether differences rhythms, between older younger individuals age-related systemic dysregulation target organs observed SARS-CoV-2 infection remain largely unknown. Current literature demonstrates emerging role development chronic pulmonary diseases infections human mouse models. exact mechanism underlying distress (ARDS) other cardiopulmonary complications patients combination with associated comorbidities unclear. Nevertheless, understanding critical clock dysfunction immune status provide insights into possible therapies. Chronotherapy is an concept gaining attention sleep medicine. Accumulating evidence suggests half physiological functions follow strict daily rhythm. healthcare professionals rarely implementing timed-administration drugs consideration. In this review, we summarize recent findings directly relating contributing roles response modulating infectious disease processes, integrate chronotherapy discussion potential can be repurposed improve treatment management COVID-19.

Language: Английский

Health-Related Behaviors Among School-Aged Children and Adolescents During the Spanish Covid-19 Confinement DOI Creative Commons
Rubén López‐Bueno, Guillermo F. López Sánchez, José A. Casajús

et al.

Frontiers in Pediatrics, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 11, 2020

In response to the Covid-19 world pandemic, affected countries such as Spain enacted measures comprising of compulsory confinement well restrictions regarding free movement. Such likely influence children's and adolescents' lifestyles. Our study aimed investigate impact that has on health-related behaviors (HRBs) among Spanish children adolescents. An online survey was administered 516 parents collect data about 860 adolescents (49.2% girls) aged between 3 16 years in relation physical activity, screen exposure, sleep time, fruit vegetable consumption during confinement. Respectively t-paired test t-test groups served check differences HRBs levels before strict relaxed Significant were found for a reduction weekly minutes activity (-102.5, SD 159.6) (p<0.001), an increase daily hours exposure (2.9, 2.1) (-0.2, 1.6) (p<0.001). Sleep time showed significant difference (-0.3, 0.1) (p<0.05), whereas binomial logistic regression adjusted covariates (age, sex, education parents, siblings, current condition, Covid-19, previous health risk behavior) significantly lower odds behavior with (OR 0.60, 95%CI 0.40-0.91). The present suggests reduced levels, increased both consumption. Therefore, most worsened this sample Closure schools, education, lack policies addressing conciliation labor family life could have played important role worsening pupils, which might be mitigated adequate policies, parental guidance, community support.

Language: Английский

Citations

259
Escalation of sleep disturbances amid the COVID-19 pandemic: a cross-sectional international study DOI Creative Commons

Uri Mandelkorn,

Shir Genzer, Shoham Choshen‐Hillel

et al.

Journal of Clinical Sleep Medicine, Journal Year: 2020, Volume and Issue: 17(1), P. 45 - 53

Published: Sept. 9, 2020

Study Objectives: The stress imposed by the COVID-19 pandemic and ensuing social isolation could adversely affect sleep.As sleep problems may persist hurt health, it is important to identify which populations have experienced changes in sleeping patterns during their extent.Methods: In 1, 3,062 responders from 49 countries accessed survey website voluntarily between March 26 April 26, 2020, 2,562 (84%; age: 45.2 ± 14.5, 68% women) completed study.In 2, 1,022 adult US were recruited for pay through Mechanical Turk, 971 (95%; age 40.4 13.6, 52% study.The tool included demographics items adapted validated questionnaires on duration, quality timing, pills consumption. Results:In 58% of unsatisfied with sleep.Forty percent reported a decreased vs before crisis.Self-reported pill consumption increased 20% (P < .001).Multivariable analysis indicated that female sex, being quarantine, 31-to 45-years group, reduced physical activity adverse impact livelihood independently associated more severe worsening pandemic.The majority findings reproduced independent cohort 2. Conclusions: Changes due led surge individuals reporting across globe.The raise need screen use aids, especially susceptible populations, namely, women people insecure livelihoods subjected isolation.

Language: Английский

Citations

156
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19 DOI Creative Commons
Daan L. de Frel, Douwe E. Atsma, Hanno Pijl

et al.

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: Nov. 19, 2020

Background: COVID-19 is a global challenge to healthcare. Obesity common in patients with and seems aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors immune system, propose societal interventions enhance immunity. Search Strategy Selection Criteria: We performed three literature searches using keywords (1) coronavirus AND comorbidities, (2) comorbidities (3) system. Results were screened for relevance by main author total of 215 articles thoroughly analyzed. Results: The relationship obesity unfavorable prognosis discussed light impact on Several modifiable render us susceptible viral infections. context, make case fostering healthy scale. Conclusions: Obesity, additional an unhealthy interactively impair function increase risk severe infectious disease. adverse metabolic endocrine conditions, system geared toward inflammation. Collective effort needed ameliorate scale resistance viruses like SARS-CoV-2.

Language: Английский

Citations

105
Burden of Sleep Disturbance During COVID-19 Pandemic: A Systematic Review DOI Creative Commons
Ying Lin, Zhuo Ran Liu, Shi Qi Li

et al.

Nature and Science of Sleep, Journal Year: 2021, Volume and Issue: Volume 13, P. 933 - 966

Published: June 1, 2021

Abstract: Coronavirus disease 2019 (COVID-19) pandemic may exert adverse impacts on sleep among populations, which raise awareness of the burden disturbance, and demand intervention strategies for different populations. We aimed to summarize current evidence COVID-19 in patients with COVID-19, healthcare workers (HWs), general population. searched PubMed Embase studies prevalence disturbance. Totally, 86 were included review, including 16 patients, 34 HWs, 36 The disturbance was 33.3%– 84.7%, 29.5– 40% hospitalized discharged survivors, respectively. Physiologic psychological traumatic effects infection interact environmental factors increase risk patients. 18.4– 84.7% contributors mainly high workloads shift work, occupation-related factors, factors. 17.65– 81% social-psychological contributed population during pandemic. In summary, highly prevalent Specific health should be implemented tackle Keywords: pandemic, SARS-CoV2

Language: Английский

Citations

84
The Circadian Clock and Viral Infections DOI Creative Commons
Helene Borrmann, Jane A. McKeating, Xiaodong Zhuang

et al.

Journal of Biological Rhythms, Journal Year: 2020, Volume and Issue: 36(1), P. 9 - 22

Published: Nov. 9, 2020

The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations biological processes behavior. Our rhythms are driven by an endogenous central in brain that synchronizes with clocks peripheral tissues, thereby regulating our immune system severity infections. These affect pharmacokinetics efficacy therapeutic agents vaccines. core regulatory circuits clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding role systems play virus infection response will inform clinical management these diseases. This review provides overview experimental evidence reporting on interplay between viral infections, highlighting importance virus-clock research.

Language: Английский

Citations

73
Sleep and COVID-19: considerations about immunity, pathophysiology, and treatment. DOI
Marco Túlio de Mello, Andressa Silva, Renato de Carvalho Guerreiro

et al.

DOAJ (DOAJ: Directory of Open Access Journals), Journal Year: 2021, Volume and Issue: 13(3), P. 199 - 209

Published: Jan. 1, 2021

The fear and uncertainty caused by the coronavirus disease 2019 (COVID-19) pandemic, threats to survival are one of main problems everyday life; however, mental health care must also be considered a priority. During social isolation called self-quarantine, restricted mobility contact, concern about financial resources availability supplies, infection, questions duration cause anxiety, depression, stress, insomnia reduced quality quantity sleep, that may present greater risk general population. Sleep disorders increasingly becoming major issue in modern society, influenced retinal stimulation electronic devices, as well extended and/or night shift-work, which aggravate systemic lung inflammation during viral infections. can induce pro-inflammatory states harmful COVID-19 pandemic. possible interactions between many drugs used treat COVID-19, those sleep unknown, mostly due lack standard protocol these patients. Insufficient or irregular sleep-wake cycles impair health, immune system, pro-inflammation state, lead increased vulnerability infections, involving inflammatory oxidative/antioxidant imbalance. In this sense, obstructive apnea has been associated with recognized comorbidities factor for COVID-19. cannot stop, telemedicine presented itself an alternative method delivering services. When face-to-face visit is mandatory, locations minimal community transmission where centers have resumed activities, it important center facilities properly prepared receive patients follow all relevant safety rules. work we gathered group researchers, specialists aspects related chronobiology, disorders, system. Thus, conducted narrative review order address relationship its immunological strategies applied mitigate effects on affects everyone

Language: Английский

Citations

67
Sleep in post-COVID-19 recovery period and its impact on different domains of quality of life DOI Creative Commons
Samir El Sayed,

Sarah Gomaa,

Doaa Shokry

et al.

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2021, Volume and Issue: 57(1)

Published: Dec. 14, 2021

Abstract Background COVID-19 pandemic became a global health problem affecting the life of millions people all over world. The effects this were not only on physical and medical aspects but also psychological issues including anxiety disorders, depressive manifestations, sleep problems others. Sleep disorders very commonly reported during novel Coronavirus-19 either in acute phase infection or after recovery. These might have drastic burden recovered patients’ life. This study aimed to investigate post-Coronavirus-19 period if has an impact different items quality cross-sectional observational investigated 500 patients post recovery using Insomnia Severity Index Pittsburgh index (PSQI), their relation critical domains Quality Life which was assessed by SF36 Health Survey. Results Socio-demographic characteristics collected; insomnia severity evaluated pattern. Short Form 36 scale. revealed high scores (13.01 ± 4.9), (15.37 4.43), scale studied group. Conclusion Post-COVID-19 disturbances period, these deficits had mental life, so must be managed properly especially era.

Language: Английский

Citations

60
Reduced Titers of Circulating Anti-SARS-CoV-2 Antibodies and Risk of COVID-19 Infection in Healthcare Workers during the Nine Months after Immunization with the BNT162b2 mRNA Vaccine DOI Creative Commons
Luca Coppeta, Cristiana Ferrari,

Giuseppina Somma

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(2), P. 141 - 141

Published: Jan. 18, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact on health services; hundreds of thousands healthcare workers (HCWs) have died from disease 2019 (COVID-19). introduction the BNT162b2 mRNA vaccine in Italy provided recipients with significant protection against COVID-19 within one to two weeks after administration second recommended doses. While induces robust T cell response, protective role factors and pathways other than those related memory B responses specific SARS-CoV-2 antigens remains unclear. This retrospective study aimed evaluate determinants serological group vaccinated HCWs (n = 793) by evaluating circulating levels antiviral spike receptor-binding domain (S-RBD) antibodies during nine-month period following vaccination. We found that 99.5% who received doses developed were maintained at detectable for as long 250 days dose vaccine. Multivariate analysis was performed anti-S-RBD titers subgroup participants 173) evaluated twice this period. results reveal antibody titer observed time point significantly magnitude primary elapsed between first evaluation, previous history infection. Of importance is finding despite waning vaccination, none contracted observational

Language: Английский

Citations

43
Circadian molecular clock disruption in chronic pulmonary diseases DOI Creative Commons

Allan Giri,

Qixin Wang, Irfan Rahman

et al.

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 513 - 527

Published: May 1, 2022

Language: Английский

Citations

41
High body mass index and night shift work are associated with COVID-19 in health care workers DOI Creative Commons
Stefano Rizza, Luca Coppeta, Sandro Grelli

et al.

Journal of Endocrinological Investigation, Journal Year: 2020, Volume and Issue: 44(5), P. 1097 - 1101

Published: Aug. 27, 2020

To assess the magnitude of COVID-19 spread and associated risk factors among health care workers (HCWs), we conducted an in-hospital survey in a central Italian COVID Hospital. Participants underwent nasopharyngeal swab and/or serum collection for SARS-CoV-2 IgG examination. We divided participants according to working status, into rotating-night shift (r-NSW) day-workers. found 30 cases infection total 1180 HCWs (2.5%). Most COVID-19-positive hospital employees were r-NSWs with significantly higher BMI than that individuals who tested negative. After adjustment covariates, night work > markedly greater diagnosis (OR 3.049 [95%CI 1.260–7.380] OR 7.15 2.91–17.51], respectively). Our results describe low prevalence at appears be obesity work, thus supporting need careful surveillance frontline exposed COVID-19.

Language: Английский

Citations

60