International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17416 - 17416
Published: Dec. 12, 2023
Cisplatin
is
a
chemotherapeutic
drug
for
the
treatment
of
several
solid
tumors,
whose
use
limited
by
its
nephrotoxicity,
neurotoxicity,
ototoxicity,
and
development
resistance.
The
toxicity
caused
DNA
cross-linking,
increase
in
reactive
oxygen
species
and/or
depletion
cell
antioxidant
defenses.
aim
work
was
to
study
effect
compounds
(Lisosan
G,
Taurisolo®)
or
hydrogen
sulfide
(H2S)-releasing
(erucin)
auditory
HEI-OC1
line
treated
with
cisplatin.
Cell
viability
determined
using
MTT
assay.
Caspase
sphingomyelinase
activities
were
measured
fluorometric
colorimetric
methods,
respectively.
Expression
transcription
factors,
apoptosis
hallmarks
genes
codifying
response
proteins
Western
blot
RT-qPCR.
Lisosan
Taurisolo®
erucin
did
not
show
protective
effects.
Sodium
hydrosulfide
(NaHS),
donor
H2S,
increased
cisplatin-treated
cells
heme
oxygenase
1,
superoxide
dismutase
2,
NAD(P)H
quinone
dehydrogenase
type
1
catalytic
subunit
glutamate-cysteine
ligase
decreased
(ROS),
Bax/Bcl2
ratio,
caspase-3,
caspase-8
acid
activity.
Therefore,
NaHS
might
counteract
cytotoxic
cisplatin
increasing
reducing
ROS
levels
caspase
Obesities,
Journal Year:
2024,
Volume and Issue:
4(3), P. 226 - 255
Published: July 22, 2024
Obesity
has
emerged
as
a
major
public
health
challenge
in
the
21st
century,
contributing
to
rising
prevalence
of
metabolic
syndrome
(MetS),
cluster
interrelated
risk
factors.
These
factors
include
obesity
or
abdominal
obesity,
type
2
diabetes
mellitus
(T2DM),
hypertension
(HTN),
and
dyslipidaemia.
In
this
review,
we
will
explore
important
aspects
regulation
dynamics
lipoprotein
metabolism
see
how
they
underlie
each
these
risks.
Additionally,
highlight
role
ferroptosis,
an
iron-dependent
regulated
cell
death
process,
relation
inflammatory
responses
its
critical
contribution
pathophysiology
MetS.
inflammasome
activation,
lipotoxicity,
influence
adipocytokines,
adipose
tissue
macrophages.
By
exploring
interconnections,
review
aims
provide
insights
into
crosstalk,
outline
pathological
mechanisms
occurring,
identify
potential
therapeutic
targets
for
managing
preventing
progression
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8685 - 8685
Published: Aug. 9, 2024
Accumulating
evidence
suggests
an
involvement
of
sphingolipids,
vital
components
cell
membranes
and
regulators
cellular
processes,
in
the
pathophysiology
both
Parkinson's
disease
major
depressive
disorder,
indicating
a
potential
common
pathway
these
neuropsychiatric
conditions.
Based
on
this
interaction
sphingolipids
synuclein
proteins,
we
explored
gene
expression
patterns
α-,
β-,
γ-synuclein
knockout
mouse
model
deficient
for
acid
sphingomyelinase
(ASM),
enzyme
catalyzing
hydrolysis
sphingomyelin
to
ceramide,
studied
associations
with
behavioral
parameters.
Normalized
Nutrition Research and Practice,
Journal Year:
2024,
Volume and Issue:
18(5), P. 602 - 602
Published: Jan. 1, 2024
Inflammation
and
ferroptosis
are
implicated
in
various
diseases
lipopolysaccharides
(LPS)
have
been
linked
with
these
disorders.
Recently,
many
edible
insects,
such
as
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 10, 2024
As
the
population
ages,
occurrence
of
osteoporosis
is
becoming
more
common.
Diabetes
mellitus
one
factors
in
development
osteoporosis.
Compared
with
general
population,
incidence
significantly
higher
diabetic
patients.
Diabetic
(DOP)
a
metabolic
bone
disease
characterized
by
abnormal
tissue
structure
due
to
hyperglycemia
and
insulin
resistance,
reduced
strength
increased
risk
fractures.
This
complex
mechanism
that
occurs
at
cellular
level
such
as
blood
vessels,
inflammation,
resistance.
Although
application
some
drugs
clinical
practice
can
reduce
DOP,
fractures
caused
DOP
still
very
high.
Extracellular
vesicles
(EVs)
are
new
communication
mode
between
cells,
which
transfer
miRNAs
proteins
from
mother
cells
target
through
membrane
fusion,
thereby
regulating
function
cells.
In
recent
years,
role
EVs
pathogenesis
has
been
widely
demonstrated.
this
article,
we
first
describe
changes
microenvironment
Second,
DOP.
Finally,
summarize
research
progress
challenges
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17416 - 17416
Published: Dec. 12, 2023
Cisplatin
is
a
chemotherapeutic
drug
for
the
treatment
of
several
solid
tumors,
whose
use
limited
by
its
nephrotoxicity,
neurotoxicity,
ototoxicity,
and
development
resistance.
The
toxicity
caused
DNA
cross-linking,
increase
in
reactive
oxygen
species
and/or
depletion
cell
antioxidant
defenses.
aim
work
was
to
study
effect
compounds
(Lisosan
G,
Taurisolo®)
or
hydrogen
sulfide
(H2S)-releasing
(erucin)
auditory
HEI-OC1
line
treated
with
cisplatin.
Cell
viability
determined
using
MTT
assay.
Caspase
sphingomyelinase
activities
were
measured
fluorometric
colorimetric
methods,
respectively.
Expression
transcription
factors,
apoptosis
hallmarks
genes
codifying
response
proteins
Western
blot
RT-qPCR.
Lisosan
Taurisolo®
erucin
did
not
show
protective
effects.
Sodium
hydrosulfide
(NaHS),
donor
H2S,
increased
cisplatin-treated
cells
heme
oxygenase
1,
superoxide
dismutase
2,
NAD(P)H
quinone
dehydrogenase
type
1
catalytic
subunit
glutamate-cysteine
ligase
decreased
(ROS),
Bax/Bcl2
ratio,
caspase-3,
caspase-8
acid
activity.
Therefore,
NaHS
might
counteract
cytotoxic
cisplatin
increasing
reducing
ROS
levels
caspase
