Atherogenic index of plasma and triglyceride-glucose index mediate the association between stroke and all-cause mortality: insights from the lipid paradox DOI Creative Commons

Jinhua Qian,

Qinjie Chi,

Chengqun Qian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 10, 2025

The "lipid paradox" describes the counterintuitive observation that traditionally unfavorable lipid profiles may be associated with improved outcomes in stroke patients. Non-traditional markers such as atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) have been proposed to better reflect complex metabolic disturbances following stroke. This study aims investigate mediating role AIP TyG association between all-cause mortality elucidate potential mechanisms underlying paradox. cohort used data from China Health Retirement Longitudinal Study (CHARLS), including 10,220 participants enrolled 2011 2020, a maximum follow-up 10 years. were calculated baseline serum measurements. U-test, chi-square test, restricted cubic spline analysis (RCS), cox proportional hazards regression mediation model analyze relationship AIP, index, mortality. A total 1,421 deaths (13.90%) occurred during an average 9.21 Compared survivors, non-survivors older, had higher prevalence stroke, lower levels (P < 0.05), while showed no significant group difference. RCS revealed nonlinear mortality, but nonlinearity for AIP. Cox identified age, gender, marital status, smoking history, hypertension, diabetes, lung disease, highest quartile (Q4) independent predictors (all P 0.05). Notably, negative (HR = 0.87, 95% CI: 0.77-0.98),demonstrating paradox phenomenon. Furthermore, chain model, both (β=-0.03, 95%CI: -0.072 -0.002) (β=-0.016, -0.036 independently mediated manner. However, positive effect through (β 0.028, 0.003-0.066) offset this mediation, rendering overall insignificant. or jointly influence risk after demonstrates Moreover, significantly increases post-stroke risk. These findings highlight interplay glucose metabolism prognosis offer novel perspective management.

Language: Английский

Association between triglyceride-glucose related indices and all-cause and cardiovascular mortality among the population with cardiovascular-kidney-metabolic syndrome stage 0–3: a cohort study DOI Creative Commons
Yanfeng Wang, De-Gang Mo, Wenhua Zeng

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 28, 2025

Cardiovascular-Kidney-Metabolic (CKM) syndrome typically commences with the interaction of insulin resistance (IR), excessive or dysfunctional obesity, and consequent systemic inflammatory response oxidative stress. The relationship between triglyceride-glucose (TyG) index TyG-related indices that may simply assess IR as well mortality risk in CKM population, remains ambiguous. This study included 6,383 participants from National Health Nutrition Examination Survey (NHANES) 2009–2018. TyG index, TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), TyG-body mass (TyG-BMI) were developed. Cox proportional hazards models, smooth curve fitting, two-stage models employed to examine association all-cause cardiovascular population. Subgroup analyses tests conducted evaluate within various demographics. In survey-weighted multifactorial regression analyses, a significant positive existed TyG, indices, both mortality, except for which did not demonstrate link mortality. Of these TyG-WC exhibited strongest correlation hazard (HR) 1.50 95% confidence interval (CI) 1.18–1.92, followed by TyG-WHtR (HR: 1.45, 95%CI 1.13–1.85). demonstrated 1.85, CI 1.19–2.86), index(HR: 1.83, 1.21–2.78). An L-shaped was identified TyG-WHtR, TyG-BMI, during examination nonlinear relationships (both P log-likelihood < 0.05). TyG-WC, TyG-BMI more pronounced those stages 1 3 (P value 0.05, Our emphasizes individuals 0–3. Individuals should be vigilant abnormal alterations indices.

Language: Английский

Citations

3
Application of Flow-Mediated Dilation in Metabolic Syndrome DOI
Yuran Ahn, Hyo–Suk Ahn

CardioMetabolic Syndrome Journal, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metabolic syndrome and bladder cancer risk: a comprehensive evidence synthesis combining bibliometric and meta-analysis approaches DOI Creative Commons

Yi Yuan,

Tongpeng Liu,

Yu Yao

et al.

BMC Urology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 21, 2025

Language: Английский

Citations

0
The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review DOI Creative Commons
Temitope Gabriel Adedeji

Journal of Clinical Sciences, Journal Year: 2025, Volume and Issue: 22(2), P. 108 - 118

Published: April 1, 2025

ABSTRACT Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including insulin resistance, obesity, dyslipidemia, and hypertension, increasing the risk cardiovascular disease diabetes. Lifestyle factors such as poor diet, sedentary behavior, smoking contribute to its rising prevalence. Emerging research suggests epigenetic modifications, DNA methylation, histone noncoding RNAs (ncRNAs), play crucial role in MetS. This review examines how lifestyle influence mechanisms that A comprehensive literature search was conducted using MEDLINE (via PubMed) Google Scholar, focusing on studies investigating effects physical activity, Relevant from reference lists were also included. Studies analyzing ncRNAs tissues prioritized. Exclusion criteria included lacking analysis or those unrelated Key data, findings, extracted, links between gene regulation. Poor diet induce modifications impair signaling, lipid metabolism, inflammation. Exercise balanced nutrition promote beneficial changes, enhancing mitochondrial function health. choices shape regulation influencing MetS risk. While habits worsen dysfunction, exercise proper can mitigate damage. Understanding these aid developing targeted interventions for prevention management.

Language: Английский

Citations

0
Association between eGDR and accelerated aging: the mediating role of ePWV DOI Creative Commons
Shun Lü, Yujun Xiong, Xiangda Meng

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 24, 2025

This study examines the association between estimated glucose disposal rate (eGDR) and accelerated aging in middle-aged older adults, with a focus on mediating role of pulse wave velocity (ePWV). Data from 2011 China Health Retirement Longitudinal Study (CHARLS) were analyzed, including participants. Biological age was using Klemera-Doubal method, defined as difference biological chronological age. The eGDR calculated based waist circumference, hypertension status, HbA1c levels, while ePWV mean blood pressure Logistic regression models assessed relationship baseline eGDR, ePWV, aging, adjusting for confounders. A total 8,529 participants (mean 59.31 years) included. significant inverse found aging. Participants lowest quartile had an 81% higher risk compared to those highest (OR = 0.19, 95% CI 0.17-0.22, P < 0.001). Mediation analysis showed that mediated 12.90% (95% 9.20%-16.60%). Reduced insulin sensitivity, indicated by low is factor Vascular measured mediates part this relationship. These findings highlight importance monitoring sensitivity vascular health mitigate age-related risks.

Language: Английский

Citations

0
Association Between Coffee Consumption and Metabolic Syndrome Components Among Saudi Adults DOI Creative Commons
Wala Alzahrani, Sarah N. Alsharif, Maryam Hafiz

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 163 - 163

Published: March 1, 2025

Background: Previous research has linked high coffee consumption to an increased risk of metabolic syndrome (MetS). This study aimed assess the relationship between and MetS components among Saudi adults. Methods: A cross-sectional was performed on adults who met at least three criteria for a diagnosis. Data concerning demographics, lifestyle, sleeping patterns, medical health, anthropometric measurements, habitual drinking, lab levels HDL-C, LDL-C, TC, TGs, HbA1c, FBG were collected. Results: Of 95 participants, 51% women, 75.8% >50 years old, obese, 62% used practicing physical activity, 74.5% never smoked, 56.4% slept < 7 h/day, 89.5% consumers. these, 94.7% had waist circumference, 63.2% BP, 47.4% FBG, 41.1% low HDL, 23.2% TGs. For consumers, 37.6% drank small cup, 34.5% once daily, 89.4% Arabic coffee, 75.3% added no additives. Conclusions: No significant association found patterns any component, with exception elevated which strongly associated cup size number daily cups. Waist circumference BMI strong positive correlation size, there cups, BMI, TC. Further prospective studies are needed establish causal relationship.

Language: Английский

Citations

0
Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study DOI Creative Commons

Juan Leonardo,

Robby Hertanto,

Reggie Surya

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 22, 2025

Metabolic syndrome (MetS) is a global health concern, characterized by combination of dyslipidemia, insulin resistance, obesity, and hypertension, significantly increasing the risk type 2 diabetes mellitus (T2DM) cardiovascular diseases. Gut microbiota plays pivotal role in MetS pathophysiology, with dysbiosis exacerbating metabolic impairments. Delites™, supplement inspired Traditional Chinese Medicine, has shown potential modulating gut mitigating MetS. This study aimed to evaluate effects Delites™ supplementation on composition male Sprague Dawley rats fed cholesterol- fat-enriched diet (CFED). A randomized preclinical trial was conducted 32 divided into four groups: control-normal, CFED, CFED+low-dose (54 mg/kg), CFED+high-dose (108 mg/kg). Parameters including lipid profiles, enzymatic activity, molecular biomarkers, were analyzed. improved reduced inflammation (TNF-α), enhanced anti-inflammatory markers (IL-10), increased energy metabolism regulator PGC-1α. modulation showed beneficial genera (Bifidobacterium, Lactobacillus) pathogenic Proteus, improving microbial diversity. effectively mitigates through modulation. These findings highlight its for precision medicine approaches combat disorders. Further research needed explore long-term translational relevance humans.

Language: Английский

Citations

0
Atherogenic index of plasma and triglyceride-glucose index mediate the association between stroke and all-cause mortality: insights from the lipid paradox DOI Creative Commons

Jinhua Qian,

Qinjie Chi,

Chengqun Qian

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 10, 2025

The "lipid paradox" describes the counterintuitive observation that traditionally unfavorable lipid profiles may be associated with improved outcomes in stroke patients. Non-traditional markers such as atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) have been proposed to better reflect complex metabolic disturbances following stroke. This study aims investigate mediating role AIP TyG association between all-cause mortality elucidate potential mechanisms underlying paradox. cohort used data from China Health Retirement Longitudinal Study (CHARLS), including 10,220 participants enrolled 2011 2020, a maximum follow-up 10 years. were calculated baseline serum measurements. U-test, chi-square test, restricted cubic spline analysis (RCS), cox proportional hazards regression mediation model analyze relationship AIP, index, mortality. A total 1,421 deaths (13.90%) occurred during an average 9.21 Compared survivors, non-survivors older, had higher prevalence stroke, lower levels (P < 0.05), while showed no significant group difference. RCS revealed nonlinear mortality, but nonlinearity for AIP. Cox identified age, gender, marital status, smoking history, hypertension, diabetes, lung disease, highest quartile (Q4) independent predictors (all P 0.05). Notably, negative (HR = 0.87, 95% CI: 0.77-0.98),demonstrating paradox phenomenon. Furthermore, chain model, both (β=-0.03, 95%CI: -0.072 -0.002) (β=-0.016, -0.036 independently mediated manner. However, positive effect through (β 0.028, 0.003-0.066) offset this mediation, rendering overall insignificant. or jointly influence risk after demonstrates Moreover, significantly increases post-stroke risk. These findings highlight interplay glucose metabolism prognosis offer novel perspective management.

Language: Английский

Citations

0