Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females DOI Creative Commons
Sara Sario, Rafael J. Mendes, Fátima Gonçalves

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 7, 2022

Abstract As a polyphagous pest, Drosophila suzukii has variety of host fruits available for feeding and oviposition, but how the nutritional geometry different hosts influences its metabolism is still poorly understood. This work aimed to evaluate D. metabolic transcriptional pathways are influenced by on fruits, sex these responses. Adult flies were allowed feed five fruit-based media. Lipids, glucose, glycogen, energy pathways-associated gene expression, quantified. Females showed an energetic easily adaptable food’s characteristics; in contrast, males’ was particularly food, predominantly those fed raspberry media who changes glucose levels expression genes associated with pathways, suggesting activation gluconeogenesis trehaloneogenesis as result deficiency. Here we present novel insight into ’s modulated depending fruits’ sex. While females high adaptability their diet, males more feeding-sensitive. These findings might be used not only control this pest population better advise producers invest less suitable based hosts’ geometry.

Language: Английский

Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity DOI Creative Commons
Jason W. Millington, George P. Brownrigg,

Charlotte F. Chao

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Jan. 15, 2021

Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work Drosophila showed that was higher females, yet mechanisms underlying increased female remain unclear. Here, we discover a protein-rich diet augments females and not males because of female-biased increase activity conserved insulin/insulin-like growth factor signaling pathway (IIS). This sex-biased upregulation IIS triggered by diet-induced stunted mRNA required insulin-like peptide 2 , illuminating new sex-specific roles for these genes. Importantly, show sex determination gene transformer promotes via transcriptional coactivator Spargel to regulate male-female difference plasticity. Together, findings provide vital insight into nutrient-dependent

Language: Английский

Citations

41
The Drosophila‐parasitizing wasp Leptopilina heterotoma: A comprehensive model system in ecology and evolution DOI Creative Commons
Maude Quicray, Léonore Wilhelm, Thomas Enriquez

et al.

Ecology and Evolution, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 1, 2023

Abstract The parasitoid Leptopilina heterotoma has been used as a model system for more than 70 years, contributing greatly to diverse research areas in ecology and evolution. Here, we synthesized the large body of work on L. with aim identify new avenues that could be interest also researchers studying other parasitoids insects. We start our review description typical characteristics, well higher taxonomic groups which this species belongs. then continue discussing host suitability immunity, foraging behaviors, fat accumulation life histories. subsequently shift focus towards parasitoid‐parasitoid interactions, including coexistence within larger guild Drosophila parasitoids, chemical communication, mating population structuring. conclude by highlighting assets system, its intermediate history syndromes, ease observing collecting natural hosts wasps, recent genomic advances.

Language: Английский

Citations

20
The Drosophila model to interrogate triacylglycerol biology DOI Creative Commons
Christoph Heier,

Svitlana Klishch,

Olha Stilbytska

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2021, Volume and Issue: 1866(6), P. 158924 - 158924

Published: March 12, 2021

The deposition of storage fat in the form triacylglycerol (TAG) is an evolutionarily conserved strategy to cope with fluctuations energy availability and metabolic stress. Organismal TAG specialized adipose tissues provides animals a reserve that sustains survival during development starvation. On other hand, excessive accumulation TAG, defined as obesity, associated increasing prevalence human diseases. During past decade, fruit fly Drosophila melanogaster, traditionally used genetics developmental biology, has been established versatile model system study metabolism etiology lipid-associated Similar humans, homeostasis relies on interplay organ systems lipid uptake, synthesis, processing, which are integrated by endocrine network hormones messenger molecules. Enzymatic formation from sugar or dietary lipid, its droplets, mobilization lipolysis occur via mechanisms largely between humans. Notably, dysfunctional occurs context aging, overnutrition, defective gene function, entails tissue-specific organismal pathologies resemble disease. In this review, we summarize physiology biochemistry outline potential organism understand genetic basis TAG-related disorders.

Language: Английский

Citations

40
Endocrine control of glycogen and triacylglycerol breakdown in the fly model DOI
Martina Gáliková, Peter Klepsatel

Seminars in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 138, P. 104 - 116

Published: April 5, 2022

Language: Английский

Citations

20
High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster DOI Creative Commons
Andrea M. Darby,

Destiny O. Okoro,

Sophia Aredas

et al.

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(8), P. e1012447 - e1012447

Published: Aug. 12, 2024

Overnutrition with dietary sugar can worsen infection outcomes in diverse organisms including insects and humans, through generally unknown mechanisms. In the present study, we show that adult Drosophila melanogaster fed high-sugar diets became more susceptible to by Gram-negative bacteria Providencia rettgeri Serratia marcescens . We found P S proliferate rapidly D a diet, resulting increased probability of host death. become hyperglycemic on find evidence extra carbon availability may promote growth within host. However, no directly supports greater growth. both fully induce transcription antimicrobial peptide (AMP) genes response infection, but provided reduced production AMP protein. Thus, overnutrition impair immunity at level translation. Our results demonstrate shape dynamics impacting pathogen, depending nutritional requirements pathogen altering physiological capacity sustain an immune response.

Language: Английский

Citations

4
Germline expression of Imp-L2 in Drosophila females enhances reproductive activity and longevity DOI Creative Commons
Su-Jin Noh,

S. L. Na,

Xinge Song

et al.

Animal Cells and Systems, Journal Year: 2025, Volume and Issue: 29(1), P. 31 - 40

Published: March 17, 2025

The Imaginal morphogenesis protein-Late 2 (Imp-L2) in Drosophila is recognized as a functional homolog of the insulin-like growth factor (IGF) binding protein family. In this study, we report that Imp-L2 expression germline cells during oogenesis simultaneously enhances both fecundity and lifespan female Drosophila. Loss Imp-L2, either through knockout or germline-specific knockdown, resulted decreased reproductive activity, evidenced by reduced ovary size fecundity, along with higher proportion infertile flies. Conversely, overexpression specifically enhanced activity. appears to regulate stem cell proliferation differentiation independently IGF signaling. Interestingly, knockdown shortened flies, whereas its extended it. Thus, promotes activity longevity, presenting an exception typical trade-off between reproduction lifespan.

Language: Английский

Citations

0
On the use of kinship and familiarity associated social information in mediating Drosophila melanogaster oviposition decisions DOI Creative Commons
Emily Rakosy, Sanduni Talagala, Tristan A. F. Long

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320377 - e0320377

Published: March 26, 2025

Decisions where an individual lays their eggs are important, as the choice may affect offspring’s survival and lifetime reproductive success. Information produced by conspecifics can potentially be useful in making decisions this “social information” provide energetically cheaper means of assessing oviposition site suitability rather than acquiring it personally. However, not all public information equally beneficial, cues kin especially valuable they might signal suitable microenvironments, associated with other fitness advantages resulting from improved foraging success and/or a decreased risk competition/cannibalism compared to sites unrelated located. Using fruit fly, Drosophila melanogaster , we explored whether use is kin-based egg-laying decisions. Kinship recognized several ways, including environmentally-associated proxy cues, so there were biases how focal females interacted that differed both genetic relatedness, environmental “familiarity.” In series inter-connected assays, examined behaviour potential substrates manner prior conspecific exposure, counted offspring eclosed these different substrates. Sites had exhibited demonstrators visited more, yielded more unexposed Furthermore, patterns bias production consistent ovipositing exhibiting sensitivity kinship status substrate’s occupants. The basis categorization appears based on phenotypes reflect true but nature social affected factors. These results further highlight usefulness D. model understand evolution expression decision-making.

Language: Английский

Citations

0
Fresh and frozen dried fruit mites (Carpoglyphus lactis) supported the rearing of a predatory mite Phytoseius leaki (Acari: Phytoseiidae) with specialised niche requirements DOI Creative Commons
Keshi Zhang,

Qiongshu Zhang,

Zhi‐Qiang Zhang

et al.

Journal of Stored Products Research, Journal Year: 2025, Volume and Issue: 112, P. 102651 - 102651

Published: April 11, 2025

Language: Английский

Citations

0
Effects of developmental and adult environments on ageing DOI Creative Commons
Krish Sanghvi, Maider Iglesias‐Carrasco, Felix Zajitschek

et al.

Evolution, Journal Year: 2022, Volume and Issue: 76(8), P. 1868 - 1882

Published: July 12, 2022

Developmental and adult environments can interact in complex ways to influence the fitness of individuals. Most studies investigating effects environment on focus experienced traits expressed at a single point an organism's life. However, vary with time, so that organisms experience different ages may affect how change throughout Here, we test whether thermal stress during development leads individuals cope better as adults. We manipulated temperature both adulthood measured range life-history traits, including senescence, male female seed beetles (Callosobruchus maculatus). found reduced reproductive performance females. In contrast, life span age-dependent mortality were affected more by than developmental environments, high temperatures decreasing longevity increasing mortality. Aside from interaction between changes weight, did not find any evidence beneficial acclimation response stress. Overall, our results show be sex trait specific, full understanding ageing requires integrated study conditions stages ontogeny.

Language: Английский

Citations

13
Sexual Dimorphism in Metabolic Responses to Western Diet in Drosophila melanogaster DOI Creative Commons
Sofie De Groef,

Tom Wilms,

Séverine Balmand

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 12(1), P. 33 - 33

Published: Dec. 27, 2021

Obesity is a chronic disease affecting millions of people worldwide. The fruit fly (Drosophila melanogaster) an interesting research model to study metabolic and transcriptomic responses obesogenic diets. However, the sex-specific differences in these are still understudied perhaps underestimated. In this study, we exposed adult male female Dahomey flies standard diet supplemented with sugar, fat, or combination both. exposure 10% sugar fat efficiently induced increase lipid content flies, hallmark for obesity. This was more prominent males, while females displayed significant changes glycogen content. A strong effect diets on ovarian size number ma-ture oocytes also present combina-tion sugar. both males females, body morphology changed associ-ated cells response expression me-tabolism-related genes sexually dimorphic under normal condi-tions and/or fat-supplemented Here, show that containing allowed studying sexual dimorphism metabolism regulating metabolism.

Language: Английский

Citations

17