Genome-wide association study for milk production and conformation traits in Canadian Alpine and Saanen dairy goats

Journal of Dairy Science, Journal Year: 2022, Volume and Issue: 106(2), P. 1168 - 1189

Published: Dec. 14, 2022

Increasing the productivity of Canadian dairy goats is critical to competitiveness sector; however, little known about underlying genetic architecture economically important traits in these populations. Consequently, objectives this study were as follows: (1) perform a single-step GWAS for milk production (milk, protein, and fat yields, protein percentages first later lactations) conformation (body capacity, character, feet legs, fore udder, general appearance, rear suspensory ligament, teats) Alpine Saanen breeds; (2) identify positional functional candidate genes related traits. The data available analysis included 305-d records 6,409 3,434 does lactation 5,827 2,632 lactations; well linear type 5,158 2,342 does. Genotypes 833 874 animals. Both single-breed multiple-breed performed using single-trait animal models. Positional then identified downstream analyses. 189 unique SNP that significant at chromosomal level, corresponding 271 within 50 kb up- downstream, across breeds This provides evidence economic importance several (e.g., CSN1S1, CSN2, CSN1S2, CSN3, DGAT1, ZNF16) populations have been previously reported other goat Moreover, novel RPL8, DCK, MOB1B) also identified. Overall, results provided greater insight into Greater understanding will help improve breeding programs.

Language: Английский

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Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing

BMC Genomics, Journal Year: 2023, Volume and Issue: 24(1)

Published: March 15, 2023

Cross breeding is an important way to improve livestock performance. As and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer Huai goat. After more than 20 years breeding, BoHuai goats showed many advantages, such as fast growth, good reproductive performance, high meat yield. In order better develop protect goats, we sequenced the whole genomes 30 5 analyze genetic diversity, population structure genomic regions under selection Furthermore, used 126 published world-wide characterize variation goat.The results that nucleotide diversity lower degree linkage imbalance higher other breeds. The analysis have obvious differences from addition, closely related highly similar Group signal study, found one region on chromosome 7 shows a very strong signal, which suggests it could well be segment intense artificial results. Through selective sweeps, detected some genes traits lipid metabolism (LDLR, STAR, ANGPTL8), fertility (STAR), disease resistance (CD274, DHPS, PDCD1LG2).In this paper, elucidated variation, ancestry composition, signals economic goats. Our studies genome will not only help understand characteristics crossbred but also provide basis for improvement cross-breeding programs.

Language: Английский

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Genome-wide mapping of signatures of selection using a high-density array identified candidate genes for growth traits and local adaptation in chickens

Genetics Selection Evolution, Journal Year: 2023, Volume and Issue: 55(1)

Published: March 23, 2023

Availability of single nucleotide polymorphism (SNP) genotyping arrays and progress in statistical analyses have allowed the identification genomic regions genes under selection chicken. In this study, SNP data from 600 K Affymetrix chicken array were used to detect signatures 23 local Italian populations. The populations categorized into four groups for comparative analysis based on live weight (heavy vs light) geographical area (Northern Southern Italy). Putative investigated by combining three extended haplotype homozygosity (EHH) approaches quantify excess within (iHS) between (Rsb XP-EHH) groups. Presence runs (ROH) islands was also analysed each group.After editing, 541 animals 313,508 SNPs available analyses. total, 15 candidate that are potentially detected among groups: eight a group iHS seven results Rsb XP-EHH, which revealed divergent largest overlap identified be chromosome 8. Twenty-one with ROH approach but none these overlapped EHH-derived statistics. Some contained biological functions related environmental stress, immune responses, disease resistance, indicate adaptation populations.Compared commercial lines, predominantly reared as backyard chickens, thus, may developed stronger resistance challenges. Our can play an important role shaping starting point identify gene mutations could useful respect climate change.

Language: Английский

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Identifying Candidate Genes for Litter Size and Three Morphological Traits in Youzhou Dark Goats Based on Genome-Wide SNP Markers

Genes, Journal Year: 2023, Volume and Issue: 14(6), P. 1183 - 1183

Published: May 29, 2023

This study aimed to reveal the potential genetic basis for litter size, coat colour, black middorsal stripe and skin colour by combining genome-wide association analysis (GWAS) selection signature ROH detection within Youzhou dark (YZD) goat population (n = 206) using Illumina GoatSNP54 BeadChip. In GWAS, we identified one SNP (snp54094-scaffold824-899720) on chromosome 11 two SNPs 26 (snp11508-scaffold142-1990450, SORCS3) 12 (snp55048-scaffold842-324525, LOC102187779) 18 (snp56013-scaffold873-22716, TCF25) stripe. contrast, no were colour. analysis, 295 significant iHS genomic regions with a mean |iHS| score > 2.66, containing signatures encompassing 232 candidate genes detected. particular, 43 GO terms KEGG pathway significantly enriched in selected genes, which may contribute excellent environmental adaptability characteristic trait formation during domestication of YZD goats. detection, 4446 segments 282 consensus regions, among nine common overlapped those detected method. Some known economic traits such as reproduction (TSHR, ANGPT4, CENPF, PIBF1, DACH1, DIS3, CHST1, COL4A1, PRKD1 DNMT3B) development growth (TNPO2, IFT80, UCP2, UCP3, GHRHR, SIM1, CCM2L, CTNNA3 CTNNA1) revealed detection. Overall, this is limited small affects results GWAS certain extent. Nevertheless, our findings could provide first overview mechanism underlying these important novel insights into future conservation utilisation Chinese germplasm resources.

Language: Английский

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Live chicken body fat measurement technology based on bio-electrical impedance

Computers and Electronics in Agriculture, Journal Year: 2024, Volume and Issue: 220, P. 108890 - 108890

Published: March 29, 2024

In chicken breeding, body fat distribution is an important genetic indicator. To address the issues of low accuracy, high workload, and limited experimental environment in traditional measurement methods, this paper proposes online method for live based on principle bio-electrical impedance. The system uses STM32F103C8T6 processor, AD5933 impedance module, four-electrode sampling core module to design system. During detection process, electrode was placed left chest-left tibia broilers, a constant excitation frequency signal 50 kHz sent electrode. feedback information then analyzed by calculated establish mathematical model correlation between values percentage. Using proposed electrical rate 30 Wenchang free-range chickens at 107-day-old were measured respectively. results show that there significant positive broilers their (P < 0.01), which consistent with previous observations characteristics At 95 % confidence level, accuracy predicted value compared actual reached 88.43 %. This study verifies feasibility principle, thereby improving convenience providing reliable data support breeding research.

Language: Английский

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