Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(10), P. 530 - 530

Published: Sept. 23, 2021

The prevalence of antimicrobial resistance reduces the effectiveness drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, viruses. Because burgeoning growth microbes with antimicrobial-resistant traits, there is a dire need to identify develop novel effective agents treat infections from strains. marine environment rich ecological biodiversity can be regarded an untapped resource for prospecting bioactive compounds. Therefore, exploring plays significant role drug development biomedical research. Several earlier scientific investigations have proven that bacterial diversity represents emerging source structurally unique agents. There are several reports on secondary metabolites, many pharmacologically enormous promise developing combat microbial drug-resistant pathogens. In this review, we attempt summarize published articles last twenty-five years (1996–2020) metabolites bacteria evolved environments, sediment, water, fauna, flora.

Language: Английский

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Epiphytic common core bacteria in the microbiomes of co-located green (Ulva), brown (Saccharina) and red (Grateloupia, Gelidium) macroalgae

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: June 1, 2023

Abstract Background Macroalgal epiphytic microbial communities constitute a rich resource for novel enzymes and compounds, but studies so far largely focused on tag-based diversity analyses or limited metagenome sequencing of single macroalgal species. Results We sampled bacteria from specimens Ulva sp. (green algae), Saccharina (brown Grateloupia Gelidium (both red algae) together with seawater sediment controls coastal reef in Weihai, China, during all seasons. Using 16S rRNA amplicon sequencing, we identified 14 core genera (consistently present macroalgae), dominant three the macroalgae). Core represented ~ 0.7% genera, yet accounted average 51.1% bacterial abundances. Plate cultivation samples yielded 5,527 strains (macroalgae: 4,426) representing 1,235 species (685 potentially novel). Sequencing selected 820 non-redundant draft genomes (506 novel), 23 metagenomes 1,619 metagenome-assembled (MAGs), further 1,183 genomes. 230 isolates 153 were obtained 28 core/dominant genera. analyzed genomic potential phycosphere to degrade algal polysaccharides produce bioactive secondary metabolites. predicted 4,451 polysaccharide utilization loci (PULs) 8,810 biosynthetic gene clusters (BGCs). These particularly prevalent Conclusions Our metabolic annotations MAGs provide new insights into their ecological niches an improved understanding microbiome.

Language: Английский

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Comparative genomic analysis of Flavobacteriaceae: insights into carbohydrate metabolism, gliding motility and secondary metabolite biosynthesis

BMC Genomics, Journal Year: 2020, Volume and Issue: 21(1)

Published: Aug. 20, 2020

Members of the bacterial family Flavobacteriaceae are widely distributed in marine environment and often found associated with algae, fish, detritus or invertebrates. Yet, little is known about characteristics that drive their ubiquity diverse ecological niches. Here, we provide an overview functional traits common to taxonomically members from different environmental sources, a focus on Marine clade. We include seven newly sequenced sponge-derived strains were also tested for gliding motility antimicrobial activity.

Language: Английский

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Ecological Role of Bacteria Involved in the Biogeochemical Cycles of Mangroves Based on Functional Genes Detected through GeoChip 5.0

mSphere, Journal Year: 2022, Volume and Issue: 7(1)

Published: Jan. 12, 2022

Bacteria have important functions in biogeochemical cycles, but studies on their function an ecosystem, mangroves, are still limited. Here, we investigated the ecological role of bacteria involved cycles seven representative mangroves southern China.

Language: Английский

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Opportunistic diseases in marine eukaryotes: Could Bacteroidota be the next threat to ocean life?

Environmental Microbiology, Journal Year: 2022, Volume and Issue: 24(10), P. 4505 - 4518

Published: June 16, 2022

Abstract Bacteria within the phylum Bacteroidota (Bacteroidetes) are known to cause devastating and widespread disease outbreaks in marine eukaryotic hosts. However, with few pathogens described detail, their prevalence virulence strategies remain largely unknown. Here, we systematically reviewed literature evaluate current understanding of that Isolates affiliated genera Tenacibaculum Aquimarina (Flavobacteriaceae) were most widely reported characterized pathogens. Although cultured isolates predominantly Flavobacteriia, culture‐independent studies also found classes Bacteroidia, Cytophagia Sphingobacteriia associated disease. We pathogenic conformed an opportunistic lifestyle but could act as secondary or involved polymicrobial diseases. Many diseases environmental stressor, especially those affecting coral, macroalgae fish. Key traits included production adhesins host tissue‐degrading enzymes. Overall, nature involving appears be outcome complex host–pathogen–environment interactions; however, our remains limited by lack functional characterization studies. This is concerning have potential emerge a serious threat ecosystems aquaculture industries, driven global changes ocean conditions.

Language: Английский

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From invasion to fish fodder: Inclusion of the brown algae Rugulopteryx okamurae in aquafeeds for European sea bass Dicentrarchus labrax (L., 1758)

Aquaculture, Journal Year: 2023, Volume and Issue: 568, P. 739318 - 739318

Published: Feb. 4, 2023

In keeping with the premises of Blue Circular Economy in European Union, present study explored possibility using invasive brown alga Rugulopteryx okamurae aquafeeds for sea bass (Dicentrarchus labrax). Assuming raw algae biomass could negatively impact animal performance, four experimental formulations were prepared, by including macroalgae material at 5%, crude (CR), enzymatically hydrolysed and fermented (EF), (E), or (F) R. biomass, which we tested against a control feed (CT). To evaluate effects diets, besides growth performance biometric parameters, devised toolbox focused on intestine intestinal function: i) ex-vivo epithelial resistance permeability Ussing chambers; ii) microbiota composition through NGS; iii) expression profiles selected markers integrity, transport, metabolism, immune response, qPCR. Our results show differentiated allometric among coupled epithelium alterations permeability, amino acid transport. Additionally, evidence dysbiosis contrasting responses between i.e. pro-inflammatory vs. anti-inflammatory, are also described. conclusion, believe that be suitable resource bass, although its use requires pre-treatment before inclusion. Otherwise, while fish still have positive gastrointestinal tract pays toll inflammatory processes.

Language: Английский

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Marine Flavobacteriaceae produce zeaxanthin via the mevalonate pathway

Marine Life Science & Technology, Journal Year: 2025, Volume and Issue: 7(1), P. 132 - 143

Published: Jan. 7, 2025

Language: Английский

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Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 16, 2025

Language: Английский

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Light and dark biofilm adaptation impacts larval settlement in diverse coral species

Environmental Microbiome, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 25, 2025

Abstract Background Recovery of degraded coral reefs is reliant upon the recruitment larvae, yet mechanisms behind larval settlement are not well understood, especially for non-acroporid species. Biofilms associated with reef substrates, such as rubble or crustose coralline algae, can induce settlement; however, specific biochemical cues and microorganisms that produce them remain largely unknown. Here, we assessed responses in five broadcast-spawning species families Merulinidae, Lobophyllidae Poritidae to biofilms developed aquaria either one two months under light dark treatments. were characterised using 16S rRNA gene sequencing identify taxa induction and/or inhibition. Results We show biofilm age critical factors development inducing biofilms, where different compositions impacted behaviour. Further, positively negatively correlated settlement, indicating potential inducers inhibitors. Although these generally each species, observed bacteria classified Flavobacteriaceae , Rhodobacteraceae Rhizobiaceae Pirellulaceae be consistently across multiple Conclusions Our work identifies novel microbial groups significantly influence which targeted discovery settlement-inducing metabolites implementation restoration programs. Furthermore, our results reinforce community on substrates plays a crucial role influencing recruitment, thereby impacting recovery reefs.

Language: Английский

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Variation of Microorganisms and Water Quality, and Their Impacts on the Production of Penaeus vannamei in Small-Scale Greenhouse Ponds

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 546 - 546

Published: Feb. 27, 2025

To study the factors affecting Penaeus vannamei production in small-scale greenhouse ponds, four ponds Jiangmen, Guangdong Province, China were selected. This investigated variation characteristics of bacterial communities and pathogens pond water shrimp intestines, as well quality during culture stage. Multivariate linear regression equations used to analyse potential production. The nitrite concentration reached its peak mid-culture stage, with a maximum 16.3 mg·L−1, whereas total nitrogen salinity highest late reaching 48.4 mg·L−1 26, respectively. dominant bacteria Marivita Rhodobacteraceae, they Bacillus Candidatus Bacilloplasma. nitrifying dominated by Nitrosomonas Nitrobacter. Pathogens detected included acute hepatopancreatic necrosis disease (AHPND), Enterocytozoon hepatopenaei (EHP), white spot syndrome virus (WSSV). counts EHP relative abundance Ardenticatenales_norank main (p < 0.01). indicates that establishing optimal communities, such Marivita, Nitrobacter, controlling AHPND is crucial for regulating environment enhancing

Language: Английский

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